Selenium Nanoparticles as Candidates for Antibacterial Substitutes and Supplements against Multidrug-Resistant Bacteria

Han, Hee-Won; Patel, Kapil D.; Kwak, Jin‐Hwan; Jun, Soo-Kyung; Jang, Tae-Su; Lee, Sung-Hoon; Knowles, Jonathan C.; Kim, Hae‐Won; Lee, Hae‐Hyoung; Lee, Jung Hwan

doi:10.3390/biom11071028

Cited by 43 publications

(30 citation statements)

References 69 publications

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“…However, this toxicity depends on the forms of Se. For example, selenium nanoparticles (SeNPs) show better bioavailability and less toxicity compared to inorganic (sodium selenite) forms [9]. Selenium is crucial for the body due to its ability to affect the activity of the selenoenzyme glutathione peroxidase, and to protect cells and tissues from damage, acting as an antioxidant.…”

Section: Introductionmentioning

confidence: 99%

Biosynthesis of Selenium Nanoparticles (via Bacillus subtilis BSN313), and Their Isolation, Characterization, and Bioactivities

et al. 2021

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Among the trace elements, selenium (Se) has great demand as a health supplement. Compared to its other forms, selenium nanoparticles have minor toxicity, superior reactivity, and excellent bioavailability. The present study was conducted to produce selenium nanoparticles (SeNPs) via a biosynthetic approach using probiotic Bacillus subtilis BSN313 in an economical and easy manner. The BSN313 exhibited a gradual increase in Se reduction and production of SeNPs up to 5–200 µg/mL of its environmental Se. However, the capability was decreased beyond that concentration. The capacity for extracellular SeNP production was evidenced by the emergence of red color, then confirmed by a microscopic approach. Produced SeNPs were purified, freeze-dried, and subsequently characterized systematically using UV–Vis spectroscopy, FTIR, Zetasizer, SEM–EDS, and TEM techniques. SEM–EDS analysis proved the presence of selenium as the foremost constituent of SeNPs. With an average particle size of 530 nm, SeNPs were shown to have a −26.9 (mV) zeta potential and −2.11 µm cm/Vs electrophoretic mobility in water. SeNPs produced during both the 24 and 48 h incubation periods showed good antioxidant activity in terms of DPPH and ABST scavenging action at a concentration of 150 µg/mL with no significant differences (p > 0.05). Moreover, 200 µg/mL of SeNPs showed antibacterial reactivity against Escherichia coli ATCC 8739, Staphylococcus aureus ATCC 9027, and Pseudomonas aeruginosa ATCC 25923. In the future, this work will be helpful to produce biogenic SeNPs using probiotic Bacillus subtilis BSN313 as biofactories, with the potential for safe use in biomedical and nutritional applications.

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Section: Introductionmentioning

confidence: 99%

Biosynthesis of Selenium Nanoparticles (via Bacillus subtilis BSN313), and Their Isolation, Characterization, and Bioactivities

et al. 2021

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“…It has been shown that spherical SeNP (35.6 ± 4.3 nm) effectively suppresses oxidative stress and apoptosis induction in C2C12 and promoting cell differentiation [134]. At the same time, selenium nanowires with a size of 10-20 µm in size with an aspect ratio of 50-100 have an extremely high antibacterial potential against a number of strains of multidrug-resistant Staphylococcus aureus [135]. SeNP are able to suppress oxidative stress, induce apoptosis of infected cells, and reduce the percentage of dying lung cells, while exerting minimal cytotoxic effects on healthy cells.…”

Section: The Mechanism Of Antiviral Action Of Selenium Mediated Throu...mentioning

confidence: 99%

Immunomodulatory and Anti-Inflammatory Properties of Selenium-Containing Agents: Their Role in the Regulation of Defense Mechanisms against COVID-19

Mal’tseva

Goltyaev

Turovsky

et al. 2022

IJMS

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The review presents the latest data on the role of selenium-containing agents in the regulation of diseases of the immune system. We mainly considered the contributions of selenium-containing compounds such as sodium selenite, methylseleninic acid, selenomethionine, and methylselenocysteine, as well as selenoproteins and selenium nanoparticles in the regulation of defense mechanisms against various viral infections, including coronavirus infection (COVID-19). A complete description of the available data for each of the above selenium compounds and the mechanisms underlying the regulation of immune processes with the active participation of these selenium agents, as well as their therapeutic and pharmacological potential, is presented. The main purpose of this review is to systematize the available information, supplemented by data obtained in our laboratory, on the important role of selenium compounds in all of these processes. In addition, the presented information makes it possible to understand the key differences in the mechanisms of action of these compounds, depending on their chemical and physical properties, which is important for obtaining a holistic picture and prospects for creating drugs based on them.

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“…Bactericidal effects of SeNPs against MSSA and MRSA were observed with SeNPs doses 80 and 160 μg/mL, respectively, while application of 40 μg/mL SeNPs exhibited bacteriostatic effects against MSSA. Moreover, SeNPs exhibited a synergistic effect with LIN against MSSA and MRSA via protein degradation [ 347 ]. Investigation of the antibacterial activity of SeNPs with sizes ranging from 43 to 205 nm showed that the maximal effectiveness against MSSA and MRSA was observed with 81 nm Se NPs (MIC: 16 ± 7 μg/mL); the SeNPs depleted internal ATP, induced ROS generation, and disrupted the membrane potential.…”

Section: Applied Nanomaterialsmentioning

confidence: 99%

Advances in Nanostructures for Antimicrobial Therapy

Jampílek

Kráľová

2022

Materials

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Microbial infections caused by a variety of drug-resistant microorganisms are more common, but there are fewer and fewer approved new antimicrobial chemotherapeutics for systemic administration capable of acting against these resistant infectious pathogens. Formulation innovations of existing drugs are gaining prominence, while the application of nanotechnologies is a useful alternative for improving/increasing the effect of existing antimicrobial drugs. Nanomaterials represent one of the possible strategies to address this unfortunate situation. This review aims to summarize the most current results of nanoformulations of antibiotics and antibacterial active nanomaterials. Nanoformulations of antimicrobial peptides, synergistic combinations of antimicrobial-active agents with nitric oxide donors or combinations of small organic molecules or polymers with metals, metal oxides or metalloids are discussed as well. The mechanisms of actions of selected nanoformulations, including systems with magnetic, photothermal or photodynamic effects, are briefly described.

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Selenium Nanoparticles as Candidates for Antibacterial Substitutes and Supplements against Multidrug-Resistant Bacteria

Cited by 43 publications

References 69 publications

Biosynthesis of Selenium Nanoparticles (via Bacillus subtilis BSN313), and Their Isolation, Characterization, and Bioactivities

Biosynthesis of Selenium Nanoparticles (via Bacillus subtilis BSN313), and Their Isolation, Characterization, and Bioactivities

Immunomodulatory and Anti-Inflammatory Properties of Selenium-Containing Agents: Their Role in the Regulation of Defense Mechanisms against COVID-19

Advances in Nanostructures for Antimicrobial Therapy

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