Selenium partially prevents cisplatin-induced neurotoxicity: A preliminary study

Erken, Haydar Ali; Koç, Emine Rabia; Yazıcı, Haşmet; Yay, Arzu; Önder, Gözde Özge; Sarıcı, Saim Furkan

doi:10.1016/j.neuro.2014.04.002

Cited by 24 publications

(20 citation statements)

References 66 publications

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“…Previous studies have shown that selenium has a neuroprotective role in various experimental pathologies, such as spinal cord injury, cerebral ischemia and neurotoxicity models (11)(12)(13)(14)(15). Similarly, in our previous study, selenium prevented neurotoxicity that was induced by cisplatin in a partial level (16). Despite the fact that selenium has a neuroprotective effect at low doses, it might be toxic for biological systems at high doses (8).…”

Section: Introductionsupporting

confidence: 74%

“…Previous studies conducted with neurotoxic agents have demonstrated the neuroprotective effect of selenium on the central and peripheral nervous systems (8,(13)(14)(15)(16). However, this study was the first to demonstrate that selenium has a neuroprotective effect on peripheral nerve injury in rats.…”

Section: Discussionmentioning

confidence: 58%

“…Half-thin sections were cut using an Ultracut E ultramicrotome, stained with toluidine blue and photographed in a light microscope (Olympus CX41, Olympus Co., Tokyo, Japan). The Image J program was used to calculate the axon counts, axon diameter and myelin thickness (16). For morphometric analysis, three sections from each rat were randomly selected.…”

Section: Electron Microscopic Examinationmentioning

confidence: 99%

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Effects of Selenium on Axon and Myelin Healing in an Experimental Sciatic Nerve Injury Model

Kızılay¹,

Erken²,

Aktaş³

et al. 2017

İstanbul Tıp Fakültesi Dergisi

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Objective: Although, the neuroprotective effects of selenium are known, its effect on peripheral nerve injury is not clear. The study was aimed to investigate whether selenium prevents axonal and myelin damage in experimental sciatic nerve injury. Materials and Methods: Twenty-eight male Wistar albino rats were divided into four groups (n=7 in each): control (C), selenium (S), injury (I), and selenium-treated injury (SI). Injury was generated by 30 second of compression via Yasargil aneurysm clip on the sciatic nerve of rats in the I and SI groups. Then, selenium was given to the S and SI groups as 1.5 mg/ kg by oral gavage at 1 st , 24 th , 48 th and 72 nd hour after surgery. According to the experimental protocol, electrophysiological, histological, and biochemical tests were performed end of the day 4. Results: Whereas the amplitude of compound action potential, nerve conduction velocity, average axon diameter, myelin thickness, myelinated/unmyelinated axons and SOD activity in red blood cells of the I group were significantly lower than those of the C, S and SI groups, the serum MDA levels of the I group were significantly higher than those of the C, S and SI groups. Conclusion:The findings of this study show that selenium decreases axonal and myelin damage after sciatic nerve injury and that this neuroprotective effect of selenium is at least partially mediated by oxidant/antioxidant mechanisms.

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Section: Introductionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 58%

Section: Electron Microscopic Examinationmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Selenium on Axon and Myelin Healing in an Experimental Sciatic Nerve Injury Model

Kızılay¹,

Erken²,

Aktaş³

et al. 2017

İstanbul Tıp Fakültesi Dergisi

Self Cite

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“…However, use of cisplatin in tumor therapy has some harmful effects which can be detected virtually on all tissues. Some side effects of cisplatin exposure are auditory toxicity, nephro-toxicity, cardio-toxicity, gonado-toxicity, hepato-toxicity, ototoxicity, central and peripheral neurotoxicity 5,6 .…”

Section: Introductionmentioning

confidence: 99%

Selenium protects cerebral cells by cisplatin induced neurotoxicity

et al. 2015

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PURPOSE:To evaluate the central nervous system toxicity of cisplatin and neuroprotective effect of selenium. METHODS:Twenty-one male Wistar albino rats were divided into three groups: control (C), cisplatin (CS), cisplatin and selenium (CSE, n=7 in each group). Cisplatin (12 mg/kg/day, i.p.) was administered to CS and CSE groups for three days. Furthermore, CSE group received 3mg/kg/day (twice-a-day as 1.5 mg/kg) selenium via oral gavage five days before cisplatin injection and continued for 11 consecutive days. The same volumes of saline were administered to C group intraperitoneally and orally at same time. RESULTS:Heterochromatic and vacuolated neurons and dilated capillary vessels in the brain were observed in the histochemical examinations of cisplatin treated group. Rats that were given a dose of 3mg/kg/day selenium decreased the cisplatin induced histopathological changes in the brain, indicating a protective effect. In addition, cytoplasmic staining of the cell for bcl-2, both cytoplasmic and nuclear staining for bax were determined to be positive in the all groups. Bax positive cells were increased in the CS group compared to C group, in contrast to decreased bcl-2 positivity.CONCLUSION: Selenium limited apototic activity and histological changes due to the cisplatin related central neurotoxicity.

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“…Selenium plays an important role in cellular redox state regulation and essential to the function of glutathione peroxidase, because it is a structural component of the active site of selenoenzyme which has critical role in protecting cellular components from oxidative damage [6][7][8]. Although protective effect of selenium against some side effects of cisplatin has been shown previously, as much as we know, this is the first study investigating the efficacy of Se against cisplatin-induced oral mucositis.…”

Section: Introductionmentioning

confidence: 78%

Preventive effect of selenium pretreatment against cisplatin-induced oral mucositis in rats

et al. 2016

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Objectives. The aim of the present study was to investigate the protective role of selenium against cisplatininduced oral mucositis in rats. Methods. Healthy wistar albino rats (n=21) were randomly divided into three groups: Cisplatin (Cis), cisplatin and selenium (Cis+Se) and control (C). Cisplatin was administered for 3 days to Cis and Cis+Se groups. Cis+Se group received selenium 5 days before cisplatin injection and continued for 11 consecutive days. Malondialdehyde (MDA) levels of the rats were determined before and at the end of experimental protocol. The tongues of rats were harvested for immunuhistochemical examinations. Results. In biochemichal analysis, MDA levels significantly increased in the Cis group (p=0.018). On the contrary, there was no significant difference between pretreatment and posttreatment MDA levels in Cis+Se group (p=0.128). In the immunohistochemical examinations of lingual tissues stained with anti-caspase-3, when the Cis and Cis+Se groups were compared, there were significantly more immunopositivity in the Cis group and significantly less immunopositivity in the Cis+Se group (p<0.05). Conclusions. Selenium might have played a protective role against cisplatin-induced oral mucositis in rats. Further studies are necessary before its clinical use in patients.Eur Res J 2017;3(1):11-15

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Selenium partially prevents cisplatin-induced neurotoxicity: A preliminary study

Cited by 24 publications

References 66 publications

Effects of Selenium on Axon and Myelin Healing in an Experimental Sciatic Nerve Injury Model

Effects of Selenium on Axon and Myelin Healing in an Experimental Sciatic Nerve Injury Model

Selenium protects cerebral cells by cisplatin induced neurotoxicity

Preventive effect of selenium pretreatment against cisplatin-induced oral mucositis in rats

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