Selenium speciation by liquid chromatography-particle beam/mass spectrometry (LC-PB/MS): application to a yeast reference material and synthetic urine

Castro, José Ignacio Fernández del; Krishna, M. Bala; Ojeda, Geovannie; Marcus, R. Kenneth

doi:10.1039/c3ay40563j

Cited by 5 publications

(1 citation statement)

References 45 publications

(92 reference statements)

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“…The central point to underscore here is that they do not perform any complex sample preparation step or hydrolysis before the LC-EI-MS analysis of any sample. Other works dedicated to studying the composition of dietary supplements by using LC-EI-MS include the determination of selenium (Se) in supplements produced from yeast [54]-additionally to the analyzes performed in the supplement, the authors also used LC-EI-MS to analyze urine from patients treated with such a product; the quantification of naturally-occurring ephedrine alkaloids in standard reference materials used to support pharmaceutical developments of drugs mainly to treat fever, cough, and asthma [43]; and the quantification of polyphenols and caffeine from Camellia sinensis extracts certified as NIST reference materials used to support surveillance of dietary supplement quality control [42].…”

Section: Potential Of Nanolc-ei-ms In Biochemical Analysismentioning

confidence: 99%

NanoLC-EI-MS: Perspectives in Biochemical Analysis

Santos

Maciel

Medina

et al. 2023

IJMS

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Although LC-MS with atmospheric pressure ionization (API) sources is the primary technique used in modern bioanalytical studies, electron ionization mass spectrometry (EI-MS) can provide some substantial advantages over it. EI-MS is a matrix effect-free technique that provides reproducible and comparable mass spectra, serving as a compound fingerprint for easy identification through automated comparison with spectral libraries. Leveraging EI-MS in biochemical studies can yield critical analytical benefits for targeted and untargeted analyses. However, to fully utilize EI-MS for heavy and non-volatile molecules, a new technology that enables the coupling of liquid chromatography with EI-MS is needed. Recent advancements in nanoLC have addressed the compatibility issues between LC and EI-MS, and innovative interfacing strategies such as Direct-EI, liquid electron ionization (LEI), and Cold-EI have extended the application of EI-MS beyond the determination of volatile organic molecules. This review provides an overview of the latest developments in nanoLC-EI-MS interfacing technologies, discussing their scope and limitations. Additionally, selected examples of nanoLC-EI-MS applications in the field of biochemical analysis are presented, highlighting the potential prospects and benefits that the establishment of this technique can bring to this field.

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Section: Potential Of Nanolc-ei-ms In Biochemical Analysismentioning

confidence: 99%