Selenium Species in Cerebrospinal Fluid and Hippocampal Volume among Individuals with Mild Cognitive Impairment

Balboni, Erica; Filippini, Tommaso; Wise, Lauren A.; Nocetti, Luca; Eichmüller, Marcel; Zamboni, Giovanna; Chiari, Annalisa; Michalke, Bernhard

doi:10.1289/ehp11445

Cited by 8 publications

(5 citation statements)

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“…Higher levels of serum selenium were also positively correlated with cognitive dysfunction in Chinese elderly individuals [202]. It is interesting to note that, in agreement with these findings, Vinceti and others [203] have recently reported a significant inverse relationship between selenium levels in the cerebrospinal fluid (CSF) and hippocampal volume in subjects diagnosed with MCI, thus indicating a potential negative role of selenium in AD development. With that said, intervention studies provide a positive look on selenium.…”

Section: Seleniumsupporting

confidence: 66%

“…Lowers risk of cognitive impairment [190,191] ↓ Aβ, ↓ pTau, ↑ cognition [192][193][194][195][196][197] Se ↓ Aβ [198], associated with improved cognition [199][200][201] or cognitive dysfunction [202,203] ↓ Aβ, ↓ pTau, ↑ cognition [204][205][206][207][208][209][210][211][212][213] Fe Associated with cognitive impairment [214] or no association with AD risk [215] ↓ Cognition [216], ↓ Aβ, ↓ pTau [217] Cu Association with increased AD risk [218], ↓ cognition [219] ↓ Aβ, ↓ cognition [220][221][222],…”

Section: Mgmentioning

confidence: 99%

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Revisiting the Role of Vitamins and Minerals in Alzheimer’s Disease

et al. 2023

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Alzheimer’s disease (AD) is the most common type of dementia that affects millions of individuals worldwide. It is an irreversible neurodegenerative disorder that is characterized by memory loss, impaired learning and thinking, and difficulty in performing regular daily activities. Despite nearly two decades of collective efforts to develop novel medications that can prevent or halt the disease progression, we remain faced with only a few options with limited effectiveness. There has been a recent growth of interest in the role of nutrition in brain health as we begin to gain a better understanding of what and how nutrients affect hormonal and neural actions that not only can lead to typical cardiovascular or metabolic diseases but also an array of neurological and psychiatric disorders. Vitamins and minerals, also known as micronutrients, are elements that are indispensable for functions including nutrient metabolism, immune surveillance, cell development, neurotransmission, and antioxidant and anti-inflammatory properties. In this review, we provide an overview on some of the most common vitamins and minerals and discuss what current studies have revealed on the link between these essential micronutrients and cognitive performance or AD.

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Section: Seleniumsupporting

confidence: 66%

Section: Mgmentioning

confidence: 99%

Revisiting the Role of Vitamins and Minerals in Alzheimer’s Disease

et al. 2023

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“…A case–control study by Gu et al (2021) suggested that increased Se concentration was correlated with an increased CI risk. Vinceti et al (2022) found that the Se concentration in the cerebrospinal fluid was inversely correlated with hippocampal volume, suggesting Se may have some role in the development of AD. Nevertheless, recent research indicates that increasing dietary Se intake has a positive effect on cognitive function ( Pereira et al, 2022 ).…”

Section: Discussionmentioning

confidence: 94%

Associations between plasma metal elements and risk of cognitive impairment among Chinese older adults

Wang,

Yang

et al. 2024

Front. Aging Neurosci.

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BackgroundThe relationship between plasma metal elements and cognitive function is unclear, especially in extremely older individuals. This present study aimed to explore the association between plasma metal concentrations and the risk of cognitive impairment (CI) in Chinese extremely older adults.MethodsIndividuals aged ≥90 years with plasm metal concentration data from the fifth wave of the 2008 Chinese Longitudinal Healthy Longevity Survey were included. Plasma selenium (Se), manganese (Mn), magnesium (Mg), calcium (Ca), iron (Fe), copper (Cu), and zinc (Zn) concentrations were measured using inductively coupled plasma optical emission spectroscopy. Cognitive function was assessed by the Chinese version of the mini-mental state examination.ResultsThe study enrolled 408 participants. Participants with CI had significantly lower plasma Se, Mn, and Fe levels and higher Ca levels than those with normal cognitive function (p < 0.05). Plasma Se, Mn, Ca, and Fe concentrations were significantly associated with CI risk in both single- and multiple-element logistic regression models. Additionally, the multiple-element model results showed that the adjusted odds ratios for CI were 0.042 (95% confidence interval 0.016–0.109), 0.106 (0.044–0.255), 7.629 (3.211–18.124) and 0.092 (0.036–0.233) for the highest quartiles compared to the lowest quartiles of Se, Mn, Ca, and Fe, respectively. Moreover, subgroup analyses by age, sex, and body mass index suggested a consistent significant correlation (p < 0.05).ConclusionTherefore, decreased plasma Se, Mn, and Fe and increased plasma Ca levels were associated with CI risk in Chinese older adults. These findings are of great significance for the development of programs to delay cognitive decline in the elderly.

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“…Thus, high levels of selenoprotein P, a protein that appears to exert both beneficial and toxic effects also depending on its dose, might have deleterious effects on cognitive function, though caution should be used in drawing such a conclusion given the aforementioned study limitations. Given the relevance of selenium metabolism in the brain 4 , 53 , the limited evidence available on the involvement of selenoprotein P in the etiology of neurological diseases in humans, and the inability of peripheral indicators (such as serum) of selenoprotein P status in relation to its central nervous system concentrations, further in vivo human studies assessing the relation between brain selenoprotein P and dementia risk are clearly warranted.…”

Section: Discussionmentioning

confidence: 99%

Selenoprotein P concentrations and risk of progression from mild cognitive impairment to dementia

Urbano

Chiari

Filippini

et al. 2023

Sci Rep

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There is a growing literature investigating the effects of selenium on the central nervous system and cognitive function. However, little is known about the role of selenoprotein P, the main selenium transporter, which can also have adverse biological effects. We conducted a prospective cohort study of individuals aged 42–81 years who received a clinical diagnosis of mild cognitive impairment. Using sandwich ELISA methods, we measured full-length selenoprotein P concentrations in serum and cerebrospinal fluid to assess the relation with dementia incidence during a median follow-up of 47.3 months. We used Cox proportional hazards regression and restricted cubic splines to model such relation. Of the 54 participants, 35 developed dementia during follow-up (including 26 cases of Alzheimer’s dementia). Selenoprotein P concentrations in serum and cerebrospinal fluid were highly correlated, and in spline regression analyses they each showed a positive non-linear association with dementia risk, particularly after excluding dementia cases diagnosed within 24 months of follow-up. We also observed differences in association according to the dementia subtypes considered. Risk ratios of dementia peaked at 2–6 at the highest levels of selenoprotein P, when compared to its median level, also depending on matrix, analytical methodology and dementia subtype. Findings of this study, the first to assess selenoprotein P levels in the central nervous system in vivo and the first to use a prospective study design to evaluate associations with dementia, suggest that higher circulating concentrations of selenoprotein P, both in serum and cerebrospinal fluid, predict progression of MCI to dementia. However, further confirmation of these findings is required, given the limited statistical precision of the associations and the potential for residual confounding.

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Selenium Species in Cerebrospinal Fluid and Hippocampal Volume among Individuals with Mild Cognitive Impairment

Cited by 8 publications

References 9 publications

Revisiting the Role of Vitamins and Minerals in Alzheimer’s Disease

Revisiting the Role of Vitamins and Minerals in Alzheimer’s Disease

Associations between plasma metal elements and risk of cognitive impairment among Chinese older adults

Selenoprotein P concentrations and risk of progression from mild cognitive impairment to dementia

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