Selenium Status during Recovery from Malnutrition: Effect of Selenium Supplementation

Murphy, Caitríona; Golden, Barbara E.; Ramdath, D. Dan; Golden, Michael

doi:10.1007/978-1-4613-0723-5_4

Cited by 3 publications

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“…In agreement with an earlier study from Sudan [8] our patients with kwashiorkor and marasmic kwashiorkor (oedematous group) showed significantly decreased levels com pared to marasmic children. Low selenium status has been observed in children with severe PEM (including kwashiorkor) from Guatemala [4], Thailand [5], Zaire [14], Ja maica [ 15] and South Africa [7], In this study there was a significant posi tive correlation between plasma Se level and albumin. This conforms with the observation of Burk et al [4] who suggested that Se defi ciency in children with kwashiorkor resulted from low plasma proteins.…”

Section: Discussionmentioning

confidence: 65%

Selenium in Malnourished Sudanese Children: Status and Interaction with Clinical Features

Salih

Mohamed²,

Galgan

et al. 1994

Ann Nutr Metab

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Plasma selenium (Se), haemoglobin (Hb) and packed cell volume (PCV) were measured in 53 malnourished Sudanese children, age 6-36 months, and 11 children who had tuberculosis. Twelve healthy well-nourished children served as controls. The mean ( ± SD) plasma Se (mg/kg) was 0.05 (0.036), 0.070 (0.040), 0.063 (0.015), 0.73 (0.012), 0.082 (0.014) in children with kwashiorkor/marasmic kwashiorkor (oedematous group), marasmus, tuberculosis and healthy controls. The mean Se level in the various groups showed a significant difference (p < 0.002). Whereas the oedematous group differed significantly from the rest, there was no difference between the means of the marasmic, underweight, tuberculous patients and controls. The mean plasma albumin ( ± SD) in oedematous group was 19.6 (6.6) g/l and ranged between 22.6 (5.0) and 33.1 (3.0) in the other groups. A significant positive correlation was found between plasma Se level, albumin, Hb and PCV (respectively, r = 0.46, p < 0.0001; r = 0.37, p < 0.001; r = 0.36, p < 0.002).

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Section: Discussionmentioning

confidence: 65%

Selenium in Malnourished Sudanese Children: Status and Interaction with Clinical Features

Salih

Mohamed²,

Galgan

et al. 1994

Ann Nutr Metab

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About the oxidative stress status in children with kwashiorkor

Albrecht

Pélissier

1995

Food and Chemical Toxicology

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Selenium in global food systems

2001

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Food systems need to produce enough of the essential trace element Se to provide regular adult intakes of at least 40 m g/d to support the maximal expression of the Se enzymes, and perhaps as much as 300 m g/d to reduce risks of cancer. Deprivation of Se is associated with impairments in antioxidant protection, redox regulation and energy production as consequences of suboptimal expression of one or more of the Secontaining enzymes. These impairments may not cause deficiency signs in the classical sense, but instead contribute to health problems caused by physiological and environmental oxidative stresses and infections. At the same time, supranutritional intakes of Se, i.e. intakes greater than those required for selenocysteine enzyme expression, appear to reduce cancer risk. The lower, nutritional, level is greater than the typical intakes of many people in several parts of the world, and few populations have intakes approaching the latter, supranutritional, level. Accordingly, low Se status is likely to contribute to morbidity and mortality due to infectious as well as chronic diseases, and increasing Se intakes in all parts of the world can be expected to reduce cancer rates.

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Selenium Status during Recovery from Malnutrition: Effect of Selenium Supplementation

Cited by 3 publications

References 3 publications

Selenium in Malnourished Sudanese Children: Status and Interaction with Clinical Features

Selenium in Malnourished Sudanese Children: Status and Interaction with Clinical Features

About the oxidative stress status in children with kwashiorkor

Selenium in global food systems

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