Selenium status in pregnancy influences children's cognitive function at 1.5 years of age

Skröder, Helena; Hamadani, Jena D.; Tofail, Fahmida; Persson, Lars‐Åke; Vahter, Marie; Kippler, Maria

doi:10.1016/j.clnu.2014.09.020

Cited by 78 publications

(76 citation statements)

References 26 publications

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“…As previous studies have indicated sex-differences in the associations of cadmium and selenium with children’s development [5, 6, 14], we assessed modification by sex by including a multiplicative interaction term in Model 3 [biomarker * sex (boy = 0 and girls = 1)]. The same approach was used in relation to maternal smoking (never = 0 and ever = 1), as smoking is a well-known source of cadmium [16] and has previously been shown to modify selenium status [28] as well as child development [23].…”

Section: Methodsmentioning

confidence: 95%

“…Selenium has also been shown to interact with thyroid metabolism [13], but studies on selenium and early-life neurodevelopment are very limited. In a mother-child cohort in Bangladesh, we recently showed that women’s selenium status during pregnancy was positively associated with their children’s cognitive development at 1.5 years of age [14]. The aim of the present study was to evaluate the impact of prenatal exposure to cadmium, selenium, and iodine on Greek children’s neurodevelopment at 4 years.…”

Section: Introductionmentioning

confidence: 97%

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Impact of prenatal exposure to cadmium on cognitive development at preschool age and the importance of selenium and iodine

et al. 2016

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The evidence regarding a potential link of low-to-moderate iodine deficiency, selenium status, and cadmium exposure during pregnancy with neurodevelopment is either contradicting or limited. We aimed to assess the prenatal impact of cadmium, selenium, and iodine on children’s neurodevelopment at 4 years of age. The study included 575 mother–child pairs from the prospective “Rhea” cohort on Crete, Greece. Exposure to cadmium, selenium and iodine was assessed by concentrations in the mother’s urine during pregnancy (median 13 weeks), measured by ICPMS. The McCarthy Scales of Children’s Abilities was used to assess children’s general cognitive score and seven different sub-scales. In multivariable-adjusted regression analysis, elevated urinary cadmium concentrations (≥0.8 µg/L) were inversely associated with children’s general cognitive score [mean change: −6.1 points (95 % CI −12; −0.33) per doubling of urinary cadmium; corresponding to ~0.4 SD]. Stratifying by smoking status (p for interaction 0.014), the association was restricted to smokers. Urinary selenium was positively associated with children’s general cognitive score [mean change: 2.2 points (95 % CI −0.38; 4.8) per doubling of urinary selenium; ~0.1 SD], although the association was not statistically significant. Urinary iodine (median 172 µg/L) was not associated with children’s general cognitive score. In conclusion, elevated cadmium exposure in pregnancy of smoking women was inversely associated with the children’s cognitive function at pre-school age. The results indicate that cadmium may adversely affect neurodevelopment at doses commonly found in smokers, or that there is an interaction with other toxicants in tobacco smoke. Additionally, possible residual confounding cannot be ruled out.Electronic supplementary materialThe online version of this article (doi:10.1007/s10654-016-0151-9) contains supplementary material, which is available to authorized users.

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Section: Methodsmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 97%

Impact of prenatal exposure to cadmium on cognitive development at preschool age and the importance of selenium and iodine

et al. 2016

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“…These factors likely exert their effects on children's cognitive and language development via multiple distal and proximal mediational pathways that range from metabolic and neuroendocrine imbalances to lack of medical/educational services to cognitive understimulation related to low-quality parenting practices. For example, limited dietary availability of certain nutrients during pregnancy has been associated with children's poorer language development in rural communities in Bangladesh (Skröder et al, in press). Limited access to medical resources has been associated with delayed diagnosis of hearing problems in rural Appalachian children in Kentucky, characterized by an increased prevalence of congenital hearing loss (Bush et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Language development in rural and urban Russian-speaking children with and without developmental language disorder

Kornilov

Lebedeva²,

Zhukova

et al. 2016

Learning and Individual Differences

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Using a newly developed Assessment of the Development of Russian Language (ORRIA), we investigated differences in language development between rural vs. urban Russian-speaking children (n = 100 with a mean age of 6.75) subdivided into groups with and without developmental language disorders. Using classical test theory and item response theory approaches, we found that while ORRIA displayed overall satisfactory psychometric properties, several of its items showed differential item functioning favoring rural children, and several others favoring urban children. After the removal of these items, rural children significantly underperformed on ORRIA compared to urban children. The urbanization factor did not significantly interact with language group. We discuss the latter finding in the context of the multiple additive risk factors for language development and emphasize the need for future studies of the mechanisms that underlie these influences and the implications of these findings for our understanding of the etiological architecture of children's language development.

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“…Selenium deficiency is implicated with maternal and fetal adverse outcomes, such as infertility, miscariagges, preeclampsia, pre-term labor, small for gestational age newborns, gestational diabetes and nervous damage of the fetus [70,71]. In addition, Skroder et al, found a possible negative impact in psychomotor and language development of children from mothers with reduced levels of selenium during pregnancy [72].…”

Section: Vitamin D Calcium Parathormone (Pth)mentioning

confidence: 99%

Nutritional deficiencies in pregnancy after surgery for morbid obesity

Alexandrou

Tzikos

Chatzi

et al. 2017

JDDD

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Objectives: The rate of morbid obesity among women of reproductive age continues to rise worldwide. Surgical treatment remains the most effective mean to face it. Anatomical, physiological and nutritional modifications lead to several challenges for pregnancy after bariatric procedures. In spite of routine supplementation after bariatric surgery, vitamin and mineral deficiency frequently appear in bariatric pregnancies. The aim of this review is to summarize the existing data on the prevalence and management of nutritional deficiencies in pregnancy after bariatric surgery. Methodology:A comprehensive search of Pubmed Database was conducted for English-language studies using a list of key words. Results:The most common post-operative deficiencies in pregnancy include iron, vitamin B12, folate, vitamin D and magnesium deficiency. Less common are selenium, vitamin A, vitamin B6 and vitamin C deficiency. Finally, copper, vitamin K, vitamin B1, vitamin E and albumin deficiencies are considered to be relatively rare.Conclusions: Pregnancy after bariatric surgery has been proven to be safe for both the mother and the fetus.However, there is still the risk of significant nutritional deficiencies with adverse effects on pregnancy and lactation.As a result, a thorough customized nutritional assessment is mandatory for every woman in reproductive age who has undergone a bariatric operation, with strict regular follow-up during pregnancy and lactation.

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Selenium status in pregnancy influences children's cognitive function at 1.5 years of age

Cited by 78 publications

References 26 publications

Impact of prenatal exposure to cadmium on cognitive development at preschool age and the importance of selenium and iodine

Impact of prenatal exposure to cadmium on cognitive development at preschool age and the importance of selenium and iodine

Language development in rural and urban Russian-speaking children with and without developmental language disorder

Nutritional deficiencies in pregnancy after surgery for morbid obesity

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