Selenium status of industrial worker

Lane, Helen W.; Warren, Doris C.; Martin, E.B.; McCowan, Jeanne

doi:10.1016/s0271-5317(83)80034-7

Cited by 17 publications

(3 citation statements)

References 20 publications

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“…Lane et al 32reported that plasma and erythrocyte Se concentrations and erythrocyte GSH-Px in oil refinery workers in Texas were significantly lower than those in controls in the same region. Similar low Se concentrations, with low blood GSH-Px activities, were also reported in power station and rubber factory workers in Poland 33.…”

Section: Discussionmentioning

confidence: 99%

Cross sectional and longitudinal study on selenium, glutathione peroxidase, smoking, and occupational exposure in coal miners

Nadif

Mp²,

Fradier-Dusch³

et al. 2001

Occup Environ Med

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Objectives-To understand the variations of selenium (Se) concentration relative to changes in occupational exposure to coal dust, taking into account age and changes in smoking habits in miners surveyed twice, in 1990 and 1994. To better understand the relation of Se concentration with glutathione peroxidase activities (GSHPx) in these miners. Methods-In 1994, blood samples were obtained from active (n=131) and retired (n=40) miners without coal worker's pneumoconiosis, in whom Se concentration was available at both surveys and in whom International Labour Organisation (ILO) profusion grade had not been changed. Active miners were exposed to high dust concentrations (n=48) or low dust concentrations (n=83). Miners were classified into three subgroups according to their estimated cumulative exposure to dust, and into three subgroups according to their smoking habits. Results-Selenium concentration and GSH-Px activities were significantly lower in active than in retired miners (Se adjusted means: 62.6 v 72.2 ng/ml p=0.01). Moreover, Se concentration was lower in miners exposed to high compared with those exposed to low dust concentrations (adjusted means: 59.4 v 65.8). In miners exposed to high dust concentrations, Se concentration was significantly lower whereas erythrocyte GSH-Px activity was significantly higher in the subgroup with estimated cumulative exposure >68 mg/ m 3 .y. In all miners, plasma GSH-Px activity was correlated with Se concentration (r=0.22, p<0.005). The 4 year Se changes were negatively related to exposure to high dust concentrations and positively related to change in exposure from high to retirement and to change from smoker to ex-smoker (p=0.01). Conclusion-The variations of Se concentration in relation to changes in occupational exposure to coal dust and in smoking habits, and the close correlation found between plasma Se concentration and GSH-Px activity suggest that both are required in antioxidant defence. These results agree well with the hypothesis that the decrease in Se concentration reflects its use against reactive oxygen species generated by exposure to coal mine dust and by smoking. (Occup Environ Med 2001;58:239-245)

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Section: Discussionmentioning

confidence: 99%

Cross sectional and longitudinal study on selenium, glutathione peroxidase, smoking, and occupational exposure in coal miners

Nadif

Mp²,

Fradier-Dusch³

et al. 2001

Occup Environ Med

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“…Assuming that Se content in diet is similar in tannery workers and in controls living in the same region, blood and urine Se levels provide information on other sources of intake of Se, and urinary excretion is the main route of elimination of this microelement (30). It can be supposed that the group of workers in this study exhibits increased demand for selenium as a result of exposure to the action of the compounds (29). It is also possible that chemical oxidant stress is responsible for low Se status of the exposed workers (31).…”

Section: Discussionmentioning

confidence: 83%

“…Neve (27) and Wasowicz (28) believe that the concentration of Se in blood and its components depends on the amount of the element in the diet. The workers of the tannery and residents of the same region, who are employed outside industry probably consume similar amounts of Se (29); therefore, differences in the diet of the examined group are probably not the cause of different concentrations of Se in their blood. Furthermore, the increased excretion of the element in urine is not the cause of decreased Se concentration.…”

Section: Discussionmentioning

confidence: 97%

The influence of atmospheric chromium on selenium content and glutathione peroxidase activity in blood of tannery workers

Gromadzińska¹,

Wąsowicz²,

Sklodowska³

et al. 1996

Environ Health Perspect

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The concentration of selenium and thiobarbituric acid reactive substances (TBARS) and activity of glutathione peroxidase (GSH-Px) were determined in blood of 34 workers of a tannery in Gniezno, Poland, who worked in an area containing chromium compounds. Fourteen workers were exposed to chromium compounds at concentrations of 0.11 +/- 0.07 mg Cr/m3 (mean +/- SD) and 20 at concentrations 5-10 times lower i.e., 0.022 +/- 0.009 mg Cr/m3. Excretion of Se in urine was measured in all of the investigated workers. Decreased Se concentration in whole blood and blood plasma and elevated TBARS concentration in blood plasma were found in the whole group of investigated tanners as compared to controls. Tanners working in areas with high chromium concentrations had a statistically significant decrease in Se concentration in blood and plasma and decreased urinary excretion of the microelement as compared with other tanners. TBARS concentration was 2.5 times lower in workers exposed to higher chromium concentrations (p < 0.005) than in other workers. Positive linear correlations were found between the concentration of Se in blood and the amount of the element excreted in urine (r = 0.48; p < 0.005), the concentration of Se in blood plasma and in urine (r = 0.46; p < 0.01), and the concentration of Se in blood and erythrocyte GSH-Px activity (r = 0.42; p < 0.02). The observed differences between Se concentration in blood and urine of tannery workers and people who are not employed in the industry may indicate a kind of specific adaptation of the body to the working environment containing chromium compounds.

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Supplementary selenium influences the response to fatty acid-induced oxidative stress in humans

Meltzer

Folmer

Wang

et al. 1997

Biol Trace Elem Res

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The mutual influences of wheat selenium (Se) and n-3 polyunsaturated fatty acids (n-3 PUFA) on plasma Se and indicators of increased oxidative stress were investigated in a randomized, double-blind study with 31 women (23.5 +/- 3.4 yr). Groups 1 and 2 ingested 5.4 g n-3 PUFA daily (as ethyl esters), whereas groups 3 and 4 received placebo capsules. Groups 2 and 3 received 3 slices of high-Se bread daily, providing 115 micrograms Se, in addition to the 77 +/- 26 micrograms Se in the diet. Groups 1 and 4 received placebo slices. Blood samples were drawn at baseline and at 3 and 6 wk. Serum Se concentrations increased in both groups given Se-enriched bread, but significantly less in subjects given n-3 PUFA (group 2). There were no changes in the plasma ratio alpha-tocopherol:mg cholesterol or plasma ascorbic acid levels. In group 1, plasma-conjugated dienes and thiobarbituric acid-reactive substances (TBARS) rose by 130% (p < 0.005) and 126% (p < 0.005), respectively. Two-way ANOVA showed significant interaction effects of Se and n-3 PUFA on changes in conjugated dienes (p = 0.03) and TBARS (p = 0.015), Se treatment apparently modifying the peroxidative effects of n-3 PUFA. In subjects receiving n-3 PUFA, changes in conjugated dienes and TBARS were negatively correlated with changes in serum Se. In summary, n-3 PUFA modified the effect of Se supplementation, whereas Se seemed to modify the peroxidative effects of n-3 PUFA.

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Selenium status of industrial worker

Cited by 17 publications

References 20 publications

Cross sectional and longitudinal study on selenium, glutathione peroxidase, smoking, and occupational exposure in coal miners

Cross sectional and longitudinal study on selenium, glutathione peroxidase, smoking, and occupational exposure in coal miners

The influence of atmospheric chromium on selenium content and glutathione peroxidase activity in blood of tannery workers

Supplementary selenium influences the response to fatty acid-induced oxidative stress in humans

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