Selenium Supplementation and Prostate Cancer Mortality

Kenfield, Stacey A.; Blarigan, Erin L. Van; DuPré, Natalie; Stampfer, Meir J.; Giovannucci, Edward; Chan, June M.

doi:10.1093/jnci/dju360

Cited by 83 publications

(60 citation statements)

References 39 publications

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“…40–45 For example, among ~4400 men initially diagnosed with localized prostate cancer, we observed more than 2.5-fold increased risk of prostate cancer death among men who reported taking ≥140 ug/day of supplemental selenium compared to those taking none (RR 2.60, 95% CI,1.44–4.70). 46 …”

Section: Introductionmentioning

confidence: 99%

What should we tell prostate cancer patients about (secondary) prevention?

Chan

Blarigan²,

Kenfield³

2014

Current Opinion in Urology

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Purpose of review Briefly summarize the epidemiologic findings of selected lifestyle factors for prostate cancer progression, metastasis, or death, with a focus on behaviors after diagnosis where possible. We conclude by providing guidance on lifestyle practices that physicians may wish to prioritize for discussion with their patients. Recent findings Growing, but still limited, evidence suggests that lifestyle factors after prostate cancer diagnosis may impact prostate cancer-specific and overall morality. In particular, smoking and obesity may increase risk of disease progression and mortality, while engaging in vigorous physical activity or brisk walking and consuming a diet rich in vegetables (particularly tomato sauce and cruciferous) and vegetable fats may lower risk. Summary Patients should be counseled not to use tobacco products; to engage in daily physical activity; to minimize sedentary behavior; to consume plenty of healthy fats (i.e. fish, nuts, vegetable oils, soybeans, avocados, flaxseed) and vegetables; to focus on getting nutrients from foods rather than supplements; and to limit refined grains, sugars, processed meat, and high-fat dairy.

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Section: Introductionmentioning

confidence: 99%

What should we tell prostate cancer patients about (secondary) prevention?

Chan

Blarigan²,

Kenfield³

2014

Current Opinion in Urology

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“…When investigating the fact, the United States Department of Agriculture identified high levels of Se in wheat grains which were used to feed the chickens [76]. Although literature relates the intake of foods rich in Se to the lower risk of emergence of diseases such as colon, stomach, prostate and lung cancer [51], there are studies that relate Se supplementation to increased risk of death due to prostate cancer [77]. However, the population along the Tapajos River in the Brazilian state of Pará presents high levels of Se in their blood in function of the considerable consumption of nuts from Bethollethia excelsa and Lecythis usitata, which have high Se levels.…”

Section: Limits Between Selenium Biofortification and Toxicitymentioning

confidence: 99%

Selenium Biofortification and the Problem of its Safety

Prado¹,

Cruz²,

Ferreira³

2017

Superfood and Functional Food - An Overview of Their Processing and Utilization

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Selenium is an essential mineral element to humans and animals because it is an important component of selenoproteins that are important for functioning of the metabolism. Because of poor soil conditions in various regions of the world, the enrichment of edible plants with selenium via the biofortification strategy has been implemented. However, selenium in the context of plant mineral nutrition appears twofold due to its biofortifying character at low concentrations and toxicity at high concentrations. In this sense, understanding of the functional mechanisms in which selenium is involved is important, ranging from its absorption and assimilation in organic compounds to its beneficial or harmful effects, considering its role in food security and human health. Therefore, this chapter addresses the key aspects related to selenium in the soil-plant-man environment and the narrow limit between biofortification and toxicity, as well as the main scientific findings on this mineral element in the biochemical, physiology and plant nutrition contexts.

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“…In der SELECT-Studie fand sich eine nicht signifikant erhöhte Inzidenz von Prostatakarzinomen bei langjähriger Einnahme von Vitamin E (400 IE/Tag), nicht jedoch von Selen (200 μg/Tag) aus Selenomethionin [383]. Dagegen fand sich in einer prospektiven Beobachtungsstudie bei 4459 Männern mit primär operablem Prostatakarzinom eine um den Faktor 2,6 hö-here Mortalität für diejenigen, die mehr als 140 μg/Tag Selen supplementierten [385]. In einer randomisierten Studie an 14 641 US-Ärzten blieb die kombinierte Einnahme von Vitamin E (400 IU/Tag) und Vitamin C (500 mg/Tag) jedoch ohne Einfluss auf das Risiko für einzelne Tumoren sowie auf das Gesamttumorrisiko [386] 11 Supportive Ernährungstherapie in der palliativen Tumortherapie und in der Sterbephase !…”

Section: Leitlinie E16unclassified

Untitled

2015

Aktuel Ernahrungsmed

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Selenium Supplementation and Prostate Cancer Mortality

Abstract: Selenium supplementation of 140 or more μg/day after diagnosis of nonmetastatic prostate cancer may increase risk of prostate cancer mortality. Caution is warranted regarding usage of such supplements among men with prostate cancer.

Cited by 83 publications

References 39 publications

What should we tell prostate cancer patients about (secondary) prevention?

What should we tell prostate cancer patients about (secondary) prevention?

Selenium Biofortification and the Problem of its Safety

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