Selenium supplementation enhances the protective response to <i>Toxocara canis</i> larvae in mice

Pilarczyk, Bogumiła; Doligalska, Maria; Donskow-Schmelter, K.; Balicka-Ramisz, A.; Ramisz, A

doi:10.1111/j.1365-3024.2008.01039.x

Cited by 15 publications

(9 citation statements)

References 40 publications

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“…In contrast, the increase of IL‐12 mRNA that was observed in mice supplemented with S. boulardii suggesting that this probiotic blocks the inhibitory effect of T. canis on IL‐12 and participates in the protection against infection. This result is consistent with other researches, who found that an increase in IL‐12, TNF‐α and IFN‐γ may enhance the protective host response against T. canis . In other helminthosis such as Schistosoma mansoni, Trichinella spiralis and Trichuris suis infection, the importance of IL‐12 for the development of a protective immune response was also demonstrated .…”

Section: Discussionsupporting

confidence: 92%

Modulation of IL‐12 and IFNγ by probiotic supplementation promotes protection against Toxocara canis infection in mice

Ávila

Leon

Moura

et al. 2016

Parasite Immunology

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In this study, supplementation with the probiotic Saccharomyces boulardii promoted a reduction in intensity of infection by Toxocara canis and modulates cytokines mRNA expression in experimentally infected mice. IL-12 gene transcription had 40-fold increase in S. boulardii supplemented uninfected mice and sevenfold increase in supplemented infected mice comparing with not supplemented group. Regarding IFNγ, similar results were observed, since probiotic supplementation induced approximately 43-fold increase, but only in uninfected mice (P < 0·05). T. canis infection upregulated IL-10 expression while S. boulardii downregulated it and no change was observed for IL-4. Thus, based in these findings; we suggest that one possible mechanism responsible for S. boulardii protection effect against T. canis infection is by the modulation of cytokines expression, especially IL-12.

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Section: Discussionsupporting

confidence: 92%

Modulation of IL‐12 and IFNγ by probiotic supplementation promotes protection against Toxocara canis infection in mice

Ávila

Leon

Moura

et al. 2016

Parasite Immunology

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“…The involvement of Se in the host antioxidative response to parasite infections has been reported for Trypanosoma crici (Gomez et al 2002), Toxocara canis (Pilarczyk et al 2008), and Heligmosomoides polygyrus (Smith et al 2005) in mice. The results of Se application differed depending on the infection course and the parasite model used.…”

Section: Introductionmentioning

confidence: 95%

Selenium supplementation at low doses contributes to the antioxidant status in Trichinella spiralis-infected rats

et al. 2010

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Selenium (Se) supplementation may prevent the formation of free radicals and lipid peroxidation processes in trichinellosis. The oxidative-antioxidant status of male Wistar rats infected or uninfected with Trichinella spiralis (Nematoda) and supplemented or unsupplemented with Sel-plex (Alltech) was tested through blood biomarkers. Sel-plex was applied to restore antioxidant defense system. The oxidative marker was malondialdehyde (MDA) concentration. The antioxidant markers were superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities and concentrations of Se and vitamin E. The animals were allocated into four groups. The experiment covered 8 weeks post infection. A mathematical model was proposed for the time course of host body weight. The model solutions were in good agreement with the experimental data. The relative rates of body weight gain were determined as growth kinetic parameters. The supplementation of the rats with dietary Se improved their antioxidant status. Increases by 10% in SOD activity, 6% in GPx activity, 13% in vitamin E concentration, 17% in plasma Se concentration, and 19% in liver Se concentration, respectively, and a decrease by 18% in serum MDA concentration were recorded in the infected and supplemented towards infected and unsupplemented rats. The reduction of muscle larvae after Sel-plex application was 63%. The mortality in infected and uninfected animals did not differ significantly. No statistically significant differences were established between the growth of the control and infected rats. At week 8, the body weight gain in the supplemented rats (both uninfected and infected) was 30% higher, compared to that in unsupplemented ones. Diet with Se could be beneficial in the treatment of diseases correlated with considerable oxidative stress, particularly parasitoses.

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“…Importantly, route of Se treatment (e.g. intraperitoneal injection vs oral ingestion) can affect antiparasite immune responses (Pilarczyk et al, 2008), adding another factor to consider in the use of Se supplementation for prevention or treatment of parasitic infections.…”

Section: Selenium and Intestinal Parasitesmentioning

confidence: 99%

The role of dietary selenium in inflammation and immunity

Huang¹,

China²,

Hoffmann³

2013

Diet, Immunity and Inflammation

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Selenium supplementation enhances the protective response to Toxocara canis larvae in mice

Cited by 15 publications

References 40 publications

Modulation of IL‐12 and IFNγ by probiotic supplementation promotes protection against Toxocara canis infection in mice

Modulation of IL‐12 and IFNγ by probiotic supplementation promotes protection against Toxocara canis infection in mice

Selenium supplementation at low doses contributes to the antioxidant status in Trichinella spiralis-infected rats

The role of dietary selenium in inflammation and immunity

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