Selenium tissue distribution changes after ethanol exposure during gestation and lactation: Selenite as a therapy

Effects of Antioxidant Supplementation on Duodenal Se-Met Absorption in Ethanol-exposed Rat Offspring In Vivo

“…This is in agreement with other studies performed by our research group [9,12] where ethanol-exposed dams had a lower Se retention, which in turn altered Se deposits in several tissues, such as the mammary gland. Our supplementation of the diet of ethanol dams increases the Se levels in milk to control values and is an effective treatment to correct the lower Se concentration found in Similarly, ethanol also modified the amount of milk consumed during the suckling period.…”

“…According to what we have previously reported [8], the effects of ethanol exposure during gestation and lactation on folic acid intestinal absorption showed that intestinal folate absorption appears to be upregulated in suckling rats. Our research group has also found, in pups exposed to ethanol and supplemented with folic acid during the gestation and lactation periods, an increase in intestinal longitude (control, alcohol and alcohol plus folic acid: 53.56 ± 1.49, 43.7 ± 0.92 and 48.36 ± 1.69 cm, respectively) and intestinal mucosa weight (control, alcohol and alcohol plus folic acid: 15 ± 0.8, 12 ± 0.8 and 15 ± 1 mg/cm 2 , respectively).We have recently described that ethanol decreases selenium (Se) retention in dams, affecting their gestational parameters and the body weight, and the antioxidant balance of their progeny [9][10][11][12]. This essential trace element is of fundamental importance to health due to the antioxidant, anti-inflammatory and chemopreventive properties attributed to its presence in at least 25 selenoproteins such as glutathione peroxidase (GPx) [13].…”

“…We have recently described that ethanol decreases selenium (Se) retention in dams, affecting their gestational parameters and the body weight, and the antioxidant balance of their progeny [9][10][11][12]. This essential trace element is of fundamental importance to health due to the antioxidant, anti-inflammatory and chemopreventive properties attributed to its presence in at least 25 selenoproteins such as glutathione peroxidase (GPx) [13].…”

Selenium or Selenium Plus Folic Acid–Supplemented Diets Ameliorate Renal Oxidation in Ethanol‐Exposed Pups

“…In previous papers, we have found that alcohol consumption causes a detrimental effect in the gestational index, the lactation survival index, and the litter size, but not in birth body weight (Jotty et al., ; Ojeda et al., ). Despite EtOH, EtOHS, and ESF (EtOH supplemented with Se + folic acid) dams intake less solid kcal than control ones (Fig.…”

Selenium dietary supplementation as a mechanism to restore hepatic selenoprotein regulation in rat pups exposed to alcohol

“…Moreover, chronic alcohol consumption during gestation and lactation produces an imbalance in Se homeostasis. The imbalance alters Se bioavailability, decreases Se retention, reduces Se levels in brain cortex, muscle, mammary glands and salivary glands, increases Se levels in the heart, liver, and spleen (Jotty et al, 2009), and decreases GPx activity in different organs in dams (Zima et al, 2001). Rat pups exposed to ethanol during gestation and lactation exhibit an imbalance in Se deposits and oxidative profile, which is less pronounced if the ethanol exposure had been accompanied by Se supplementation to the dams .…”