Selenium, zinc, and copper levels and their relation with HbA1c status in children with type 1 diabetes mellitus

Ozenc, Salim; Saldır, Mehmet; Sarı, Erkan; Çeti̇nkaya, Semra; Yesilkaya, Sirzat; Babacan, Oguzhan; Fidanci, Kursat; Sayal, Ahmet; Balamtekin, Necati; Yeşilkaya, Ediz

doi:10.1007/s13410-015-0327-y

Cited by 10 publications

(17 citation statements)

References 22 publications

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“…This agrees with Özenç et al who found a negative correlation between the A1c % with serum Se, Zn, and erythrocyte GPx and no correlation was detected between A1c % and serum Cu. 1 Also, Maher and Shaaban found that serum Zn, Mg, and Cu levels were negatively correlated with A1c %. 14 Another study found a negative correlation between GSH with FPG and no correlation between GPx with FPG.…”

Section: Discussionmentioning

confidence: 93%

“…They explained the low serum Se level in patients with T1D might be due to its consumption by the increased activity of the antioxidant GSH-GPx system in order to reduce the free radicals produced by increased oxidative stress. 1 …”

Section: Discussionmentioning

confidence: 99%

“…The trace elements like selenium (Se), zinc (Zn), and copper (Cu) are involved in the process of lipid peroxidation and play an important role in the pathogenesis and exacerbation of diabetic complications. 1 Zn is very important for glucose metabolism and plays a key role in the synthesis, storage, and secretion of insulin. 2 Magnesium (Mg) is important for glucose metabolism and its deficiency has been implicated in insulin resistance, carbohydrate intolerance, dyslipidemia and complications of diabetes.…”

Section: Introductionmentioning

confidence: 98%

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Trace elements and oxidative stress in children with type 1 diabetes mellitus

Alghobashy¹,

Alkholy²,

Talat³

et al. 2018

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BackgroundThe early imbalances of trace elements in type 1 diabetes (T1D) may cause disturbance of glucose metabolism and more oxidative stress that may enhance the development of insulin resistance and diabetic complications. We aim to evaluate the serum level of selenium (Se), zinc (Zn), magnesium (Mg), and copper (Cu), the degree of oxidative stress and evaluate their relations to glycemic control in children with T1D.MethodsA case–control study which included 100 diabetic children and 40 healthy children age, sex, and ethnicity-matched as a control group. The diabetic children were divided into poor and good controlled patients according to glycosylated hemoglobin (A1c %). Studied children underwent history taking, clinical examination and laboratory measurement of serum Se, Zn, Mg, and Cu levels, erythrocyte reduced glutathione (GSH) and peroxidase enzyme activity (GPx).ResultsSerum Se, Zn, Mg, Cu, erythrocyte GSH, and GPx were significantly lower in the diabetic group in comparison to the control group (P<0.05) and their levels were lower in poorly controlled patients compared to good controlled patients (P<0.05). The serum Se, Zn, Mg, erythrocyte GSH, and GPx showed a negative correlation with A1c %. The serum Se showed a positive correlation with erythrocyte GSH and GPx ([r=0.56, P<0.001], [r=0.78, P<0.001], respectively).ConclusionChildren with T1D, especially poorly controlled cases, had low serum Se, Zn, Mg, Cu, GSH, and GPx. Low serum Se in diabetic children may affect the erythrocyte GSH-GPx system.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

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Trace elements and oxidative stress in children with type 1 diabetes mellitus

Alghobashy¹,

Alkholy²,

Talat³

et al. 2018

DMSO

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“…After removing duplicates, 3312 titles and abstracts were screened, leading to a careful selection of 239 full text articles to be assessed for further eligibility. Of these, 226 articles were excluded for not meeting the inclusion criteria, leaving 13 eligible studies to be included in the qualitative synthesis [34,35,[44][45][46][36][37][38][39][40][41][42][43]. Detailed process of literature search and study selection is presented in Figure 1.…”

Section: Literature Search and Study Selectionmentioning

confidence: 99%

Selenium Levels in Pediatric Patients With Endocrine Diseases: Evidence From a Systematic Review

et al. 2021

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Selenium (Se) is essential micronutrient involved in several physiological processes. In many regions around the world, a suboptimal intake of Se has been reported in several health conditions, also in pediatric age. Studies on association between Se level and diseases in children reported contrasting results. We took an aim to perform a systematic review of literature and provide evidence-based conclusion on the magnitude of Se deficit in endocrine diseases in children. PubMed, ISI WoS, and Scopus databases were searched to identify eligible studies, published until July 25, 2019. Methodological quality was assessed using Newcastle–Ottawa Scale. After careful selection, 13 eligible studies were included. Majority were conducted in Turkey (n=5) and Iran (n=5), and sample size varied from 61 to 628 children, with a mean (±SD) age of cases from 5.1±1.6 months up to 13.8±4.5 years. Eleven studies focused on different thyroid diseases, and two on children with type 1 diabetes mellitus (T1DM). In goitrous patients, Se level ranged from mean (±SD), 25.71±20.68 μg/L to 114.9±34.1 μg/L, while in patients with T1DM was 20.9±12.9 μg/mL and mean (95% CI)=58.4 μg/L (55.0–63.09). We may conclude that goiter and thyroid dysfunction are prominent signs of Se deficiency in children. Although deficiency of iodine and selenium are usually combined in some area, our systematic review showed that Se deficiency is important goitrogenic factor in school children. Further randomized controlled trials are needed to adequately explore the role of Se in endocrine disorders in children, across different populations and regions.

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“…Results from animal studies revealed that selenium-dependent proteins (seleno-proteins) with redox properties are involved in glucose metabolism, given that insulin release and signaling are influenced by the cellular redox potential ( 70 ). Significantly lower levels of Se and Zn were found in children affected by T1D and glycosylated hemoglobin (HbA1c) levels appeared inversely correlated with Se and Zn levels ( 71 ). Moreover, Zn concentration in drinking and stream water has been inversely associated to T1D ( 72 , 73 ).…”

Section: Early Nutrition and Its Role In T1dmentioning

confidence: 99%

Early Nutrition and Risk of Type 1 Diabetes: The Role of Gut Microbiota

et al. 2020

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Type 1 diabetes (T1D) appears most frequently in childhood, with an alarming increasing incidence in the last decades. Although the genetic predisposition is a major risk factor, it cannot solely explain the complex etiology of T1D which is still not fully understood. In this paper, we reviewed the most recent findings on the role of early nutrition and the involvement of the gut microbiota in the etiopathogenesis of T1D. The main conclusions that are withdrawn from the current literature regarding alleviating the risk of developing T1D through nutrition are the encouragement of long-term breast-feeding for at least the first 6 months of life and the avoidance of early complementary foods and gluten introduction (before 4 months of age) as well as cow milk introduction before 12 months of life. These detrimental feeding habits create a gut microbiota dysbiotic state that can contribute to the onset of T1D in infancy. Finally, we discussed the possibility to introduce probiotics, prebiotics and post-biotics in the prevention of T1D.

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Selenium, zinc, and copper levels and their relation with HbA1c status in children with type 1 diabetes mellitus

Cited by 10 publications

References 22 publications

Trace elements and oxidative stress in children with type 1 diabetes mellitus

Trace elements and oxidative stress in children with type 1 diabetes mellitus

Selenium Levels in Pediatric Patients With Endocrine Diseases: Evidence From a Systematic Review

Early Nutrition and Risk of Type 1 Diabetes: The Role of Gut Microbiota

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