Seleno-lentinan prevents chronic pancreatitis development and modulates gut microbiota in mice

Ren, Guoqing; Yu, Min; Li, Koukou; Hu, Yang; Wang, Yu; Xu, Xiuhong; Qu, Juanjuan

doi:10.1016/j.jff.2016.01.035

Cited by 44 publications

(12 citation statements)

References 53 publications

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“…The study also evaluated the anti-inflammatory activity of mushroom extracts obtained from the in vitro cultures of L. edodes grown on control media and the ones enriched with Zn, Cu, and Se compounds. The results confirmed antiinflammatory activity of mushroom material (inflammation was induced with a commonly used agent LPS) which was in line with previous studies on edible mushroom species that demonstrated their potential anti-inflammatory effect [5,[30][31][32][33][34].…”

Section: Resultssupporting

confidence: 90%

Lentinula edodes as a Source of Bioelements Released into Artificial Digestive Juices and Potential Anti-inflammatory Material

Muszyńska

Kała

Włodarczyk

et al. 2019

Biol Trace Elem Res

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Lentinula edodes (shiitake), an edible and medicinal mushroom, was chosen for this study with the aim of evaluating the possibility of release of bioelements into artificial digestive juices and analyzing the anti-inflammatory properties. The extracts were prepared from fruiting bodies and biomass enriched with copper (Cu), zinc (Zn), and selenium (Se). The content of bioelements was analyzed by total reflection X-ray fluorescence method. Relatively low content of elements was observed in the fruiting bodies: Cu-1.6, Zn-7.6, and Se-0.12 mg/100 g d.w. compared to mycelial cultures. The anti-inflammatory properties were evaluated in RAW 264.7 cells. Based on the levels of cyclooxygenase 2 protein, nuclear factor erythroid 2-related factor 2, and peroxisome proliferator-activated receptor γ determined using Western blot technique, it was found that the addition of bioelements enhanced the anti-inflammatory properties of mycelium. This indicates that L. edodes cultured on a suitable medium may be used as a potential component of anti-inflammatory products. Keywords Shiitake. Biologically active elements. Extraction in digestive juices. Medicinal properties of mushrooms. RAW 264.7 cells * Bożena Muszyńska

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Section: Resultssupporting

confidence: 90%

Lentinula edodes as a Source of Bioelements Released into Artificial Digestive Juices and Potential Anti-inflammatory Material

Muszyńska

Kała

Włodarczyk

et al. 2019

Biol Trace Elem Res

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“…SRRS and NRRS could reduce the serum CRP, IL‐6,TNF‐α and NF‐κB levels in diabetic mice and the role of SRRS is more significant. Also, in Guangming Ren's experiments, oral supplementation of selenite, lentinan and seleno‐lentinan significantly decreased serum TNF‐α and IL‐1β levels compared with modelling control group . The possible mechanism is to inhibit the nuclear transcription factor pathway, thus reducing the secretion of inflammatory factors.…”

Section: Resultsmentioning

confidence: 98%

“…Also, in Guangming Ren's experiments, oral supplementation of selenite, lentinan and seleno-lentinan significantly decreased serum TNF-and IL-1 levels compared with modelling control group. 47 The possible mechanism is to inhibit the nuclear transcription factor pathway, thus reducing the secretion of inflammatory factors. wileyonlinelibrary.com/jsfa SRRS-and NRRS-treated mice had lower LEP mRNA and higher ADPN mRNA expression levels in adipose tissue.…”

Section: Resultsmentioning

confidence: 99%

Effects of a treatment with Se‐rich rice flour high in resistant starch on enteric dysbiosis and chronic inflammation in diabetic ICR mice

et al. 2016

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“…Ren et al . have shown that the oral intake of selenium lentinan proportionally increases the gut levels of Lactobacillus , Bacteroides , Prevotella and Roseburia and reduces the gut levels of Firmicutes, Alistipes , Parabacteroides , Ruminococcus and Helicobacter .…”

Section: Animal Studiesmentioning

confidence: 99%

Association between the gut microbiota and mineral metabolism

2017

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The aim of this review is to present the most recent scientific evidence of interactions between the intestinal microbiota and minerals, and the effect of this interaction on the health of the host. The Web of Science database from the years 2013-2017 on this topic was reviewed. Numerous in vitro studies have shown that iron significantly affects the intestinal microbiota. However, Bifidobacteriaceae are capable of binding iron in the large intestine, thereby limiting the formation of free radicals synthesized in the presence of iron, and thus reducing the risk of colorectal cancer. Animal studies have revealed that supplementation with probiotics, prebiotics and synbiotics has a significant effect on bone calcium, phosphate and bone metabolism. The dynamic interaction between microbiota and zinc was shown. Human studies have provided evidence of the influence of probiotic bacteria on parathormone, calcium and phosphate levels and thus on bone resorption. Recent studies have produced new information mainly on the impact of the intestinal bacteria on the metabolism of calcium and iron. From a scientific perspective, the most urgent fields that remain to be investigated are the identification of all human gut microbes and new therapies targeting the interaction between intestinal bacteria and minerals. © 2017 Society of Chemical Industry.

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Seleno-lentinan prevents chronic pancreatitis development and modulates gut microbiota in mice

Cited by 44 publications

References 53 publications

Lentinula edodes as a Source of Bioelements Released into Artificial Digestive Juices and Potential Anti-inflammatory Material

Lentinula edodes as a Source of Bioelements Released into Artificial Digestive Juices and Potential Anti-inflammatory Material

Effects of a treatment with Se‐rich rice flour high in resistant starch on enteric dysbiosis and chronic inflammation in diabetic ICR mice

Association between the gut microbiota and mineral metabolism

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