Seleno-polymannuronate attenuates neuroinflammation by suppressing microglial and astrocytic activation

Bi, Decheng; Lai, Qiuxian; Han, Qingguo; Cai, Nan; He, Hanxing; Fang, Weishan; Jiang, Yi; Li, Xiaofan; Xu, Hong; Li, Xiuting; Hu, Zhangli; Liu, Qiong; Xu, Xu

doi:10.1016/j.jff.2018.10.010

Cited by 21 publications

(17 citation statements)

References 36 publications

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“…Polymannuronate (PM) is an alginate-separated acidic polymer. It is an edible brown algae linear block polysaccharide that is commonly used in the production of food [154]. Seleno-polymannuronate (Se-PM) is a seleno-derivative of PM prepared in the laboratory.…”

Section: Anti-neuroinflammation Activity Of Polysaccharidesmentioning

confidence: 99%

Natural Polysaccharides as Preventive and Therapeutic Horizon for Neurodegenerative Diseases

et al. 2021

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Neurodegenerative diseases are a serious and widespread global public health burden amongst aging populations. The total estimated worldwide global cost of dementia was US$818 billion in 2015 and has been projected to rise to 2 trillion US$ by 2030. While advances have been made to understand different neurodegenerative disease mechanisms, effective therapeutic strategies do not generally exist. Several drugs have been proposed in the last two decades for the treatment of different types of neurodegenerative diseases, with little therapeutic benefit, and often with severe adverse and side effects. Thus, the search for novel drugs with higher efficacy and fewer drawbacks is an ongoing challenge in the treatment of neurodegenerative disease. Several natural compounds including polysaccharides have demonstrated neuroprotective and even therapeutic effects. Natural polysaccharides are widely distributed in plants, animals, algae, bacterial and fungal species, and have received considerable attention for their wide-ranging bioactivity, including their antioxidant, anti-neuroinflammatory, anticholinesterase and anti-amyloidogenic effects. In this review, we summarize different mechanisms involved in neurodegenerative diseases and the neuroprotective effects of natural polysaccharides, highlighting their potential role in the prevention and therapy of neurodegenerative disease.

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Section: Anti-neuroinflammation Activity Of Polysaccharidesmentioning

confidence: 99%

Natural Polysaccharides as Preventive and Therapeutic Horizon for Neurodegenerative Diseases

et al. 2021

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“…This oligosaccharide also reduced the expression of toll-like receptor 4 (TLR4) and NF-κB [ 97 ]. Priming of LPS-stimulated primary microglia and astrocytes with seleno-polymannuronate (Se-PM) reduced the expression of inflammatory enzymes and the production of inflammatory mediators by suppressing NF-κB and MAPK signaling [ 98 ]. Sargachromenol isolated from Sargassum micracanthum attenuated inflammatory response in LPS-induced RAW 264.7 macrophages [ 99 ].…”

Section: Neuropharmacological Potentials Of Marine Algae and Theirmentioning

confidence: 99%

Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances

et al. 2020

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Beyond their significant contribution to the dietary and industrial supplies, marine algae are considered to be a potential source of some unique metabolites with diverse health benefits. The pharmacological properties, such as antioxidant, anti-inflammatory, cholesterol homeostasis, protein clearance and anti-amyloidogenic potentials of algal metabolites endorse their protective efficacy against oxidative stress, neuroinflammation, mitochondrial dysfunction, and impaired proteostasis which are known to be implicated in the pathophysiology of neurodegenerative disorders and the associated complications after cerebral ischemia and brain injuries. As was evident in various preclinical studies, algal compounds conferred neuroprotection against a wide range of neurotoxic stressors, such as oxygen/glucose deprivation, hydrogen peroxide, glutamate, amyloid β, or 1-methyl-4-phenylpyridinium (MPP+) and, therefore, hold therapeutic promise for brain disorders. While a significant number of algal compounds with promising neuroprotective capacity have been identified over the last decades, a few of them have had access to clinical trials. However, the recent approval of an algal oligosaccharide, sodium oligomannate, for the treatment of Alzheimer’s disease enlightened the future of marine algae-based drug discovery. In this review, we briefly outline the pathophysiology of neurodegenerative diseases and brain injuries for identifying the targets of pharmacological intervention, and then review the literature on the neuroprotective potentials of algal compounds along with the underlying pharmacological mechanism, and present an appraisal on the recent therapeutic advances. We also propose a rational strategy to facilitate algal metabolites-based drug development.

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“…A number of studies have reported that Secontaining compounds possess more potent activities than Sefree compounds for neuroprotection (Steinbrenner et al, 2006;Loef et al, 2011). In our previous study, Se-PM was shown to markedly suppress the nuclear translocation of nuclear factor-kB (NF-kB) (Bi et al, 2018b). Specifically, the promoter region of BACE1 has numerous NF-kB binding sites (Sambamurti et al, 2004); thus, Se-PM might reduce the transcription of the BACE1 gene via inhibition of NF-kB binding to DNA, decreasing the expression of BACE1.…”

Section: Se-pm Suppresses Ab Pathway In N2a-sw Cellsmentioning

confidence: 98%

“…For example, Se-PM decreased the ROS production through increasing the expressions of antioxidant enzymes including superoxide dismutase (SOD) and glutathione peroxidase (GPx) in N2a-sw cells (Zhu et al, 2013). Also, Se-PM inhibited ROS generation in lipopolysacharide (LPS)stimulated RAW264.7 macrophages (Bi et al, 2018b). On the basis of the previous research work, we report the optimization of the preparation process of sulfated polymannuronate (S-PM), the compositional and structural characteristics of PM, S-PM, and Se-PM including the degree of sulfation, Se content and average molecular weight, and the inhibition of Ab oligomer aggregation in vitro and neuroprotection effect in N2a-sw cells of Se-PM.…”

Section: Introductionmentioning

confidence: 97%

Characterization and Neuroprotection Potential of Seleno-Polymannuronate

et al. 2020

Front. Pharmacol.

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Seleno-polymannuronate (Se-PM) was prepared from alginate-derived polymannuronate (PM) through a sulfation followed by a selenylation replacement reaction. The organic selenium content of Se-PM was 437.25 mg/g and its average molecular weight was 2.36 kDa. The neuroprotection effect of Se-PM and corresponding molecular mechanisms were investigated. Our results showed that, comparing to both sulfated PM (S-PM) and PM, Se-PM remarkably inhibited the aggregation of Ab 1-42 oligomer in vitro and significantly reduced the APP and BACE1 protein expression in N2a-sw cells, highlighting the critical function of the selenium presented in Se-PM. Moreover, Se-PM decreased the expression of cytochrome c and the ratio of Bax to Bcl-2, and enhanced the mitochondrial membrane potential in N2a-sw cells. These results suggested that Se-PM treatment can markedly inhibit N2a-sw cell apoptosis and promote N2a-sw cell survival and that Se-PM might be a potential therapeutic agent for the prevention of neurodegeneration owing to its remarkable neuroprotection effect.

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Seleno-polymannuronate attenuates neuroinflammation by suppressing microglial and astrocytic activation

Cited by 21 publications

References 36 publications

Natural Polysaccharides as Preventive and Therapeutic Horizon for Neurodegenerative Diseases

Natural Polysaccharides as Preventive and Therapeutic Horizon for Neurodegenerative Diseases

Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances

Characterization and Neuroprotection Potential of Seleno-Polymannuronate

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