Selenocysteine in proteins—properties and biotechnological use

Johansson, Linda; Gafvelin, Guro; Arnér, Elias S.J.

doi:10.1016/j.bbagen.2005.05.010

Cited by 312 publications

(290 citation statements)

References 258 publications

(226 reference statements)

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“…longum, whereas SeCys was not detected. A possible reason for this may be that there is no genetic code UGA in the genome of B. longum, while SeCys is a genetically encoded amino acid translated into proteins by reading of the UGA codon (Johansson et al, 2005). Therefore, Se was mainly incorporated into protein of B. longum as SeMet.…”

Section: Identification Of Selenium Speciation In Se-b Longummentioning

confidence: 99%

Preparation of Selenium-enriched Bifidobacterium Longum and its Effect on Tumor Growth and Immune Function of Tumor-Bearing Mice

Wang¹,

Wang²,

Wang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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In this study, we demonstrated selenium (Se) accumulation in Bifidobacterium longum strain (B. longum) and evaluated the effect of Se-enriched B. longum (Se-B. longum) on tumor growth and immune function in tumor-bearing mice. Analysis using high-performance liquid chromatography-inductively coupled plasma mass spectrometry (HPLC-ICP-MS) revealed that more than 99% of Se in Se-B. longum was organic, the main component of which was selenomethionine (SeMet). In the in vivo experiments, tumor-bearing mice (n=8) were orally administrated with different doses of Se-B. longum alone or combined with cyclophosphamide (CTX). The results showed that the middle and high dose of Se-B. longum significantly inhibited tumor growth. When Se-B. longum and CTX were combined, the antitumor effect was significantly enhanced and the survival time of tumor-bearing mice (n=12) was prolonged. Furthermore, compared with CTX alone, the combination of Se-B. longum and CTX stimulated the activity of natural killer (NK) cells and T lymphocytes, increasing the levels of interleukin-2 (IL-2) and tumor necrosis factor-α (TNF-α), and the leukocyte count of H22 tumor-bearing mice (n=12).

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Section: Identification Of Selenium Speciation In Se-b Longummentioning

confidence: 99%

Preparation of Selenium-enriched Bifidobacterium Longum and its Effect on Tumor Growth and Immune Function of Tumor-Bearing Mice

Wang¹,

Wang²,

Wang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…The second group, including the rest of selenoproteins, are characterized by the presence of Sec in the N-terminal region, in between a ␤-strand and an ␣-helix, as part of a redox-active thioredoxin-like selenylsulfide/selenolthiol motif (110,111,164). Thus, human diseases associated with selenium deficiency may be attributed to increased oxidative stress and alterations in redox signaling.…”

Section: Selenoproteins In Physiology and Pathologymentioning

confidence: 99%

Untitled

2007

Antioxidants & Redox Signaling

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“…In contrast, there was an up-regulation of GSH-Px in gilts supplemented with organic Se in synchrony with the prooxidative conditions brought by ovulation. The inorganic source of Se (selenite, the dietary form routinely used in animal nutrition) is rapidly transformed to selenide and Sephosphate (9)(10)(11) and short-circuits the transsulfuration and the regulation of GSH-Px by redox changes. Therefore, it appears that inorganic Se produces a readily and persistent response to GSH-Px, independent of the need for this enzyme, while the response to seleno-AA directs the Se flow through a succession of metabolic steps in response to redox changes.…”

Section: Effects Of Amino Acids On Reproductive Performance Of the Sowsmentioning

confidence: 99%

“…Seleno-cysteine is either supplied directly by the diet or is derived from seleno-methionine after transsulfuration, a metabolic reaction that is up-regulated by redox changes (7) . Then, it is mineralised to selenide and Se phosphate (9)(10)(11) and resynthesised into a seleno-cysteinyl moiety that modulates gene expression and activates Sedependent enzyme, GSH-Px (9,12) . This metabolic control was observed recently in pigs (13) by studying homoeostasis of Se-dependent GSH-Px during the peri-estral period under oxidative pressure (Fig.…”

Section: Effects Of Amino Acids On Reproductive Performance Of the Sowsmentioning

confidence: 99%

Towards amino acid recommendations for specific physiological and patho-physiological states in pigs

et al. 2012

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The objective of this review is to provide an overview of the implication of amino acids (AA) in important physiological functions. This is done in the context of pig production where the competition for AA utilisation is exacerbated by constraints to maximise productive responses and the necessity to reduce dietary protein input for environmental, economic and sanitary issues. Therefore, there is an opportunity to refine the nutritional recommendations by exploring the physiological roles of AA. For example, methionine and cysteine, either in selenised or sulfur forms, are directly involved in the regulation of the glutathione antioxidative system. In sows, glutathione antioxidative system may contribute to improving ovulation conditions through control of oxidative pressure. Supplementation of sow diets withl-arginine, a precursor of NO and polyamines, may stimulate placental growth, promoting conceptus survival, growth and tissue development. The beneficial effect of arginine supplementation has been also suggested to improve lactation performance. Feed intake is usually the first response that is impacted by an inadequate AA supply. Valine and tryptophan imbalances may act as signals for decreasing feed intake. AA are also important nutrients for maintaining the animal's defence systems. Threonine, one of the main constituents of mucin protein, is important for gut development during the postnatal period. It may exert a protective effect that reduces the impact of weaning on gut morphology and associated disturbances. Finally, tryptophan is involved in the regulation of the defence system through its action as a precursor of antioxidants and its effect on the inflammatory response.

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Selenocysteine in proteins—properties and biotechnological use

Cited by 312 publications

References 258 publications

Preparation of Selenium-enriched Bifidobacterium Longum and its Effect on Tumor Growth and Immune Function of Tumor-Bearing Mice

Preparation of Selenium-enriched Bifidobacterium Longum and its Effect on Tumor Growth and Immune Function of Tumor-Bearing Mice

Untitled

Towards amino acid recommendations for specific physiological and patho-physiological states in pigs

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