Selenocysteine modulates resistance to environmental stress and confers anti-aging effects in C. elegans

Kim, Jun-Sung; Kim, Sohyeon

doi:10.6061/clinics/2017(08)07

Cited by 14 publications

(14 citation statements)

References 51 publications

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“…Dietary supplementation with antioxidants including silymarin and phycoerythin can enhance locomotion rate and increase lifespan (36,37). Lifespan-extending selenocysteine can also significantly delay age-related decline of motility in C. elegans (38).…”

Section: Discussionmentioning

confidence: 99%

Cur2004-8, a synthetic curcumin derivative, extends lifespan and modulates age-related physiological changes in <i>Caenorhabditis elegans </i>

Kim

Baek

et al. 2019

DD&T

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Curcumin, a compound found in Indian yellow curry, is known to possess various biological activities, including anti-oxidant, anti-inflammatory, and anti-cancer activities. Cur2004-8 is a synthetic curcumin derivative having symmetrical bis-alkynyl pyridines that shows a strong anti-angiogenic activity. In the present study, we examined the effect of dietary supplementation with Cur2004-8 on response to environmental stresses and aging using Caenorhabditis elegans as a model system. Dietary intervention with Cur2004-8 significantly increased resistance of C. elegans to oxidative stress. Its anti-oxidative-stress effect was greater than curcumin. However, response of C. elegans to heat stress or ultraviolet irradiation was not significantly affected by Cur2004-8. Next, we examined the effect of Cur2004-8 on aging. Cur2004-8 significantly extended both mean and maximum lifespan, accompanying a shift in time-course distribution of progeny production. Age-related decline in motility was also delayed by supplementation with Cur2004-8. In addition, Cur2004-8 prevented amyloid-beta-induced toxicity in Alzheimer's disease model animals which required a forkhead box (FOXO) transcription factor DAF-16. Dietary supplementation with Cur2004-8 also reversed the increase of mortality observed in worms treated with high-glucose-diet. These results suggest that Cur2004-8 has higher anti-oxidant and antiaging activities than curcumin. It can be used for the development of novel anti-aging product.

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Section: Discussionmentioning

confidence: 99%

Cur2004-8, a synthetic curcumin derivative, extends lifespan and modulates age-related physiological changes in <i>Caenorhabditis elegans </i>

Kim

Baek

et al. 2019

DD&T

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“…At the cellular level, selenium levels can extend the replicative life span of human fibroblasts when added during early-stage expansion ( 14 ). In addition, dietary supplementation of Sec, a selenium-containing cysteine, leads to lifespan extension in C. elegans ( 21 ). However, the relationship between Sec and replicative senescence in hMSCs is not known.…”

Section: Resultsmentioning

confidence: 99%

“…However, in Drosophila, selenocysteine synthesis was not essential for oxidative stress and longevity ( 20 ). Interestingly, a recent study demonstrated that dietary supplementation of Sec could modulate resistance to environmental stress, with anti-aging effects in Caenorhabditis elegans ( C. elegans ) ( 21 ). Despite these observations at the organismal level, a potential role for Sec in mammalian cells during cellular senescence has not been demonstrated.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant effects of selenocysteine on replicative senescence in human adipose-derived mesenchymal stem cells

Suh¹,

Lee²

2017

BMB Rep.

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In most clinical applications, human mesenchymal stem cells (hMSCs) are expanded in large scale before their administration. Prolonged culture in vitro results in cellular senescence-associated phenotypes, including accumulation of reactive oxygen species (ROS) and decreased cell viabilities. Profiling of stem cell-related genes during in vitro expansion revealed that numerous canonical pathways were significantly changed. To determine the effect of selenocysteine (Sec), a rare amino acid found in several antioxidant enzymes, on the replicative senescence in hMSCs, we treated senescent hMSCs with Sec. Supplementation of Sec in the culture medium in late-passage hMSCs reduced ROS levels and improved the survival of hMSCs. In addition, a subset of key antioxidant genes and Sec-containing selenoproteins showed increased mRNA levels after Sec treatment. Furthermore, ROS metabolism and inflammation pathways were predicted to be downregulated. Taken together, our results suggest that Sec has antioxidant effects on the replicative senescence of hMSCs.

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“…Selenoprotein can also reverse age-related decline of molting in C. elegans ( 27 ). Our previous study has shown that dietary supplementation with selenocysteine can increase resistance to environmental stressors such as oxidative stress and ultraviolet irradiation in C. elegans ( 28 ). Selenocysteine can also extend lifespan of C. elegans without reducing its fertility.…”

Section: Introductionmentioning

confidence: 99%

“…Selenocysteine can also extend lifespan of C. elegans without reducing its fertility. It can also delay age-related decline of its motility ( 28 ).…”

Section: Introductionmentioning

confidence: 99%

Selenocysteine mimics the effect of dietary restriction on lifespan via SKN‑1 and retards age‑associated pathophysiological changes in Caenorhabditis�elegans

Kim

Park

2018

Mol Med Report

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Selenocysteine, a sulfur-containing amino acid, can modulate cellular oxidative stress defense systems by incorporating into anti-oxidant enzymes such as glutathione peroxidase and thioredoxin reductase. Selenocysteine can also prevent cancer, neurodegenerative diseases and cardiovascular diseases. A recent study revealed that dietary supplementation with selenocysteine can increase the resistance of Caenorhabditis elegans to environmental stressors and its lifespan. The objective of the present study was to identify the underlying mechanism involved in the lifespan-extending effect of selenocysteine and the effect of selenocysteine on age-associated pathophysiological changes. Lifespan assays with known long-lived mutants of age-1 (the ortholog of the phosphoinositide 3-kinase), clk-1 (the ortholog of demethoxyubiquinone hydroxylase) and eat-2 (a ligand-gated ion channel subunit) revealed that the effect of selenocysteine on lifespan specifically overlapped with that of the eat-2 mutation, a genetic model of dietary restriction (DR). Selenocysteine mimicked the effect of DR on the bacterial dilution method. It required SKN-1 (the ortholog of mammalian nuclear factor-erythroid-related factor) for lifespan extension. In addition, selenocysteine significantly delayed the paralysis induced by human amyloid-β gene, positively correlated with the incidence of Alzheimer's disease. The effect of selenocysteine on amyloid-β-induced toxicity was dependent on the nuclear localization of DAF-16. Reduced survival caused by high-glucose-diet was recovered by selenocysteine. Selenocysteine also reduced the cellular level of reactive oxygen species known to be increased by high-glucose-diet. The results of the present study suggested that selenocysteine can mimic the effect of DR on lifespan and age-associated pathophysiological alterations, providing scientific evidence for the development of DR mimetics using selenocysteine.

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Selenocysteine modulates resistance to environmental stress and confers anti-aging effects in C. elegans

Cited by 14 publications

References 51 publications

Cur2004-8, a synthetic curcumin derivative, extends lifespan and modulates age-related physiological changes in <i>Caenorhabditis elegans </i>

Cur2004-8, a synthetic curcumin derivative, extends lifespan and modulates age-related physiological changes in <i>Caenorhabditis elegans </i>

Antioxidant effects of selenocysteine on replicative senescence in human adipose-derived mesenchymal stem cells

Selenocysteine mimics the effect of dietary restriction on lifespan via SKN‑1 and retards age‑associated pathophysiological changes in Caenorhabditis�elegans

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