Selenomethionine Ameliorates Cognitive Impairment, Decreases Hippocampal Oxidative Stress and Attenuates Dysbiosis in D-Galactose-Treated Mice

Abstract

The prevalence of age-related cognitive impairment is increasing as the proportion of older individuals in the population grows. It is therefore necessary and urgent to find agents to prevent or ameliorate age-related cognitive impairment. Selenomethionine (SeMet) is a natural amino acid occurring in yeast and Brazil nuts. It mitigates cognitive impairment in an Alzheimer’s disease mouse model, however, whether it works on age-related cognitive impairment remains unknown. In this study, SeMet significantly improved the performance of D-galactose-treated mice in the novel object recognition test, passive avoidance task and Morris water maze test. SeMet reversed D-galactose-induced reduction of hippocampal acetylcholine levels, suppression of choline acetyltransferase activity and activation of acetyl cholinesterase. It decreased D-galactose-induced oxidative stress and increased the selenoprotein P levels in the hippocampus. Besides, it attenuated D-galactose-induced dysbiosis by increasing the α-diversity and modulating the taxonomic structure. Correlations between certain taxa and physiological parameters were observed. Our results provide evidence of the effectiveness of SeMet on ameliorating D-galactose-induced cognitive impairment and suggest SeMet has potential to be used in the prevention or adjuvant treatment of age-related cognitive impairment.

Digestive and Absorptive Properties of the Antarctic Krill Tripeptide Phe-Pro-Phe (FPF) and Its Auxiliary Memory-Enhancing Effect

“…Compared to the model group, the Ach content increased, and the AchE activity decreased in the FPF group ( P < 0.05). Similar to the results of Wang et al and Gao et al, treatment with FPF significantly inhibited AChE activity, effectively increased ACh levels, and ameliorated learning and memory impairment, suggesting that attenuating Ach and AChE dysregulation in the hippocampus was one of the strategies used by FPF to alleviate scopolamine-induced cognitive impairment.…”

Attenuation of Chronic Stress-Induced Depressive-like Symptoms by Fish Oil via Alleviating Neuroinflammation and Impaired Tryptophan Metabolism in Aging Rats

“…The cognitive function was used to assess the effects of d -galactose administration. The study of Guo et al revealed that d -galactose administration increased oxidative stress and impaired cognitive function in mice . We found that d -galactose also caused a decrease in the NORT preference index in the A group.…”

Calcitriol Alleviates AKI Via Inhibiting Intestinal Inflammation and Restoring Intestinal Microbiota

“…On the one hand, the abundance of LPS-producing bacteria in the intestines (Bacteriaceae and Proteobacteria) was increased. On the other hand, SCFAs-producing bacteria, especially those that produce acetic acid and butyric acid were decreased in intestinal contents (Lachnospiraceae, Ruminococcaceae and Clostridia) (31,32). Intestinal defense is reduced, leading to the disruption of intestinal homeostasis, which adversely affects the host and exacerbates internal dysfunction in the host.…”