Selenoprotein P and Yunnan Endemic Sudden Cardiac Death—an Ecological Study

Li, Q.; Li, X. Z.; Wang, T.; Zhou, Ling-wang; Feng, Huiyun; Lin, Gen‐Min; Pei, Junrui; Lin, Chunqing; Jiang, Cheng

doi:10.1007/s12011-012-9530-6

Cited by 6 publications

(2 citation statements)

References 9 publications

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“…A search was performed for papers reporting relationships between plasma SEPP1 concentrations and clinical signs associated with the Kashin-Beck and Keshan diseases. An ecological study reported inverse correlations between SEPP1 concentrations and number of Yunnan endemic sudden cardiac deaths (r = -0.98, p = 0.02) (Li et al, 2013). The areas of the cases largely overlap with the endemic areas of Keshan disease.…”

Section: Panel Consideration Of Comments Receivedmentioning

confidence: 97%

Outcome of a public consultation on the Draft Scientific Opinion of the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) on Dietary Reference Values for selenium

2014

EFSA Supporting Publications

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Section: Panel Consideration Of Comments Receivedmentioning

confidence: 97%

Outcome of a public consultation on the Draft Scientific Opinion of the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) on Dietary Reference Values for selenium

2014

EFSA Supporting Publications

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“…The main manifestations of the patients include unconsciousness, cough with hemoptysis, shortness of breath, oliguria, and edema. The changes in ECG are even more pronounced in chronic cases, such as atrial fibrillation and right bundle-branch block with left anterior hemiblock (89).…”

Section: Chronic Kdmentioning

confidence: 99%

Keshan Disease: A Potentially Fatal Endemic Cardiomyopathy in Remote Mountains of China

et al. 2021

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Keshan disease (KD) as an endemic, highly lethal cardiomyopathy, first reported in northeast China's Keshan County in 1935. The clinical manifestations of patients with KD include primarily congestive heart failure, acute heart failure, and cardiac arrhythmia. Even though some possible etiologies, such as viral infection, fungal infection, microelement deficiency, and malnutrition, have been reported, the exact causes of KD remain poorly known. The endemic areas where KD is found are remote and rural, and many are poor and mountainous places where people are the most socioeconomically disadvantaged in terms of housing, income, education, transportation, and utilization of health services. To date, KD is a huge burden to and severely restricts the economic development of the local residents and health systems of the endemic areas. Although efforts have been made by the government to control, treat, and interrupt disease transmission, the cure for or complete eradication of KD still requires global attention. For this reason, in this review, we systematically describe the etiological hypothesis, clinical manifestations, incidence characteristics, and treatment of KD, to facilitate the better understanding of and draw more attention to this non-representative cardiovascular disease, with the aim of accelerating its elimination.

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A Spatial Ecology Study of Keshan Disease and Hair Selenium

Zhang

Wang

et al. 2018

Biol Trace Elem Res

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Few spatial ecological studies on hair selenium (Se) and Keshan disease (KD) have been reported. To investigate the relationships of hair Se with KD and economic indicators and to visualize the evidence for KD precise prevention. An ecological study design was employed. The levels of hair Se of 636 adult men (≥ 18 years old) living in rural, general cities and developed cities in 15 KD endemic provinces and 11 KD non-endemic provinces in mainland China were measured using hydride generation atomic fluorescence spectrometry. Spatial description and spatial analysis of hair Se were conducted. The subjects were adults aged. The hair Se level of the residents of KD endemic areas was 0.30 mg/kg, statistically significantly lower than that of non-endemic areas 0.34 mg/kg (Mann-Whitney U test, p = 0.007). The hair Se level of the 636 people was 0.33 mg/kg. The hair Se levels of the residents of the developed cities, general cities, and rural were 0.35 mg/kg, 0.33 mg/kg, and 0.32 mg/kg, respectively, with statistical significance (Kruskal-Wallis H test, P = 0.032). Spatial regression analysis showed that the spatial distribution of hair Se was positively correlated with per capita GDP. Selenium deficiency may still exist among residents living in the KD endemic areas. The results of spatial description and analysis of hair Se provided visualized evidence for targeting key provinces for precise prevention of Keshan disease, including assessment of KD elimination. The hair Se level of the mainland Chinese males was probably between 0.31 and 0.33 μg/g in 2015.

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Selenoprotein P and Yunnan Endemic Sudden Cardiac Death—an Ecological Study

Cited by 6 publications

References 9 publications

Outcome of a public consultation on the Draft Scientific Opinion of the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) on Dietary Reference Values for selenium

Outcome of a public consultation on the Draft Scientific Opinion of the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) on Dietary Reference Values for selenium

Keshan Disease: A Potentially Fatal Endemic Cardiomyopathy in Remote Mountains of China

A Spatial Ecology Study of Keshan Disease and Hair Selenium

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