Selenoproteins and maternal nutrition

Pappas, Athanasıos C.; Zoidis, Evangelos; Surai, Peter F.; Zervas, G.

doi:10.1016/j.cbpb.2008.08.009

Cited by 172 publications

(120 citation statements)

References 184 publications

Supporting

Mentioning

113

Contrasting

Unclassified

Order By: Relevance

“…Selenium (Se) is a trace element known to play a pivotal role in the antioxidant defence system, protecting the organism from oxidative stress (Pappas et al, 2008;Zoidis et al, 2010). The majority of studies examining ways to reduce Cd toxicity with Se were conducted in mammals using inorganic Se (Jihen et al, 2008;Messaoudi et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

The role of organic selenium in cadmium toxicity: effects on broiler performance and health status

Al-Waeli

Zoidis

Pappas

et al. 2013

Animal

Self Cite

View full text Add to dashboard Cite

This work was part of a project designed to assess whether organic selenium (Se) can protect against the toxic effects of cadmium (Cd). A total of 300 1-day-old, as hatched, broilers were randomly distributed in four dietary treatments with five replicate pens per treatment. In T1 treatment, broilers were fed a diet with 0.3 mg/kg added Se, as Se-yeast, without added Cd; in T2, broilers were fed a diet with 0.3 mg/kg Se and 10 mg/kg Cd; in T3, broilers were fed a diet with 0.3 mg/kg Se and 100 mg/kg of Cd; and in T4 treatment broilers were fed a diet with 3 mg/kg Se and 100 mg/kg Cd. The Cd was added to diets T2, T3 and T4 as CdCl 2 . On the 4th and 6th week, two broilers per replicate pen were killed in order to obtain whole blood, liver, kidney and breast samples. Body mass, feed conversion ratio and mortality were assessed and haematological analyses were performed. Se and Cd levels in tissues were analysed by inductively coupled plasma mass spectrometry. Broilers supplemented with 0.3 mg/kg Se can tolerate low levels of Cd added to the diets, as there were no significant negative effects on the examined performance parameters, whereas addition of excess Cd led to an impairment of broilers' performance. Mortality of broilers did not differ between the four dietary treatments at any interval point or the whole period. The examined haematological parameters such as haematocrit, total blood protein concentration, and leukocytes types ranged within physiological values, revealing no negative health effects after simultaneous Cd and Se addition. The present study indicated that Se can help against the negative effects of Cd, but cannot counteract all of its negative effects.

show abstract

Section: Introductionmentioning

confidence: 99%

The role of organic selenium in cadmium toxicity: effects on broiler performance and health status

Al-Waeli

Zoidis

Pappas

et al. 2013

Animal

Self Cite

View full text Add to dashboard Cite

show abstract

“…This is why the balance of unsaturated fatty acids (UFA), especially PUFA, and antioxidants (e.g., seleno-compounds, tocopherols, lycopenes) in animal feed is a critical factor influencing the quality of edible carcass parts of farm animals. Early studies using laboratory animals found that the level of PUFA in tissues, especially cholesterol esters and phospholipids in serum, was positively correlated with the selenium (Se) concentration in the diet (Shweizer et al, 2005;Pappas et al, 2008;Yu et al, 2008). Se is an essential part of at least 25 Se-proteins with antioxidant, chemoprotective, and anti-inflammatory properties; the most important are glutathione peroxidases, thioredoxin reductases, iodothyronine deiodinases, selenophosphate synthetase, selenoprotein P, and selenoprotein (Rayman, 2004;Navarro-Alarcon and CabreraVique, 2008).…”

Section: Introductionmentioning

confidence: 99%

Dietary lycopenes, selenium compounds and fish oil affect the profile of fatty acids and oxidative stress in chicken breast muscle

et al. 2012

View full text Add to dashboard Cite

The aim of the study was to determine the influence of the addition for 6 weeks of 12 ppm lycopene (Lyc), 2% fish oil (FO) and/or 0.25 ppm Se as selenate (Se VI ) or selenized yeast (SeY) to an isoenergetic and isonitrogenous basal ration containing sunflower oil (SO) as the source of energy on the liveweight (LW) and feed intake per kg body weight gain of pullets and cockerels. The effects of these additives on the concentrations of fatty acids (FA), especially mono-(MUFA) and polyunsaturated (PUFA) acids, and the yield of PUFA peroxidation (oxidative stress) in breast muscles of chickens were also investigated. Feeding broilers with the experimental rations slightly increased the live body weight of chickens compared with the controls. The ration containing SeY, Lyc, and FO most effectively increased the LW of cockerels, while that of pullets was most efficiently increased by the ration enriched in SeY and Lyc, irrespective of the presence of extra FO. SeY in the ration with Lyc most efficiently elevated feed conversion efficiency (FCE), while Se VI in the ration containing Lyc most effectively decreased FCE. The addition of Se VI to the ration enriched in Lyc significantly elevated the sum of saturated fatty acids (SFA), MUFA, and PUFA in muscles of pullets and, especially, cockerels in comparison with all other examined groups. In contrast, FO added to the ration containing Lyc, irrespective of the presence of Se VI or SeY, decreased the muscle sum of SFA, MUFA, and PUFA, and increased the concentration of docosahexaenoic acid in muscles of chickens compared with the control and all other experimental groups. FO added to the ration, regardless of the presence of Se VI or SeY, elevated the value of the long-chain n-3 PUFAto-SFA ratio and significantly decreased the values of the n-6 PUFA/n-3 PUFA ratio in muscles of pullets and cockerels. The ration containing Lyc and Se VI most efficiently increased the value of the 3 Corresponding author: e-mail: m.czauderna@ifzz.pan.pl Journal of Animal and Feed Sciences, 21, 2012, 705-724 706 LYCOPENES AND Se COMPOUNDS -FA IN CHICKEN MUSCLE PUFA/SFA ratio in the muscles of pullets and, especially, cockerels. The ration containing FO and Lyc most significantly increased the accumulation of malondialdehyde (MDA) in muscles of pullets and, in particular, cockerels, while addition of Se VI or SeY to the ration enriched in FO and Lyc most considerably decreased the concentration of MDA in breast muscles compared with the control and all other experimental groups. We propose an MDA index (calculated as: MDAindex = (MDA+PUFA)/ PUFA) as an original indicator of PUFA peroxidation in tissues of living organisms.Our results of feeding diets with Lyc, FO, and Se as Se VI or SeY constitute useful information for nutritionists carrying out investigations to improve chicken performance and the nutritional quality of feed, as well as to improve the nutritive value of chicken meat from the aspect of human health.

show abstract

“…Previous studies have shown that different selenoproteins have different characteristics and functional activities in the body. The selenoproteins belonging to the GPx family (GPx1-GPx6), Txnrd family (Txnrd1, Txnrd2, and Txnrd3), and the Dio family (Dio1, Dio2, and Dio3) play vital roles in redox regulation, antioxidant defense, the conversion of T4 to T3, and immune regulation in human diseases (Bellinger et al 2009;Pappas et al 2008). Other selenoproteins have also been identified in mammals and chickens, such as SPS2, Seli, Selk, Selm, Sel-15, Sepw1, Selh, Selv, Sepn1, Selo, Sepp1, Seli, Sels, and Selt (Mariotti et al 2012;Novoselov et al 2007).…”

Section: Discussionmentioning

confidence: 99%

“…SPS2 selenophosphate and Sepp1 transport Se in the body (Pappas et al 2008). Sel-15, Sels, and Selk control protein folding in the endoplasmic reticulum (ER; Du et al 2010aDu et al , 2010b.…”

Section: Discussionmentioning

confidence: 99%

“…In chicken, 25 selenoproteins have been identified (Mariotti et al 2012). Selenoproteins are recognized by their different characteristics and functions (Bellinger et al 2009;Pappas et al 2008). Se deficiency induces pancreatic injury due to decreased mRNA levels of Txnrd2, GPx1, GPx3, Seli, Dio1, Sepp1, Sepw1, Selo, Selt, Selm, Sepx1, and SPS2 in chicken (Zhao et al 2014b).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Selenoproteins and heat shock proteins play important roles in immunosuppression in the bursa of Fabricius of chickens with selenium deficiency

Khoso

Yang

Liu

et al. 2015

Cell Stress and Chaperones

View full text Add to dashboard Cite

Selenium (Se) is necessary for the immune system in chicken and mediates its physiological functions through selenoproteins. Heat shock proteins (Hsps) are indispensable for maintaining normal cell function and for directing the immune response. The aim of the present study was to investigate the effects of Se deficiency on the messenger ribonucleic acid (mRNA) expression levels of selenoproteins and Hsps as well as immune functions in the chicken bursa of Fabricius. Two groups of chickens, namely the control and Se-deficient (L group) groups, were reared for 55 days. The chickens were offered a basal diet, which contained 0.15 mg Se/kg in the diet fed to the control group and 0.033 mg Se/kg in the diet fed to the L group. We performed real-time quantitative polymerase chain reactionto detect the mRNA expression levels of selenoproteins and Hsps on days 15, 25, 35, 45 and 55. Western blotting was used to determine the protein expression levels of Hsps on days 35, 45 and 55, and immune functions were assessed through an enzyme-linked immunosorbent assay on days 15, 35, and 55. The data showed that the mRNA expression levels of selenoproteins, such as Txnrd1, Txnrd2, Txnrd3, Dio1, Dio2, Dio3, GPx1, GPx2, GPx3 GPx4, Sepp1, Selo, Sel-15, Sepx1, Sels, Seli, Selu, Selh, and SPS2, were significantly lower (P<0.05) in the L group compared with the control group. Additionally, the mRNA and protein expression levels of Hsps (Hsp27, Hsp40, Hsp60, Hsp70, and Hsp90) were also significantly higher (P<0.05) in the L group. The expression levels of IL-2, IL-6, IL-8, IL-10, IL-17, IL-1β, IFN-α, IFN-β, and IFN-γ were significantly lower (P<0.05) and TNF-α was significantly higher (P<0.05) in the L group compared with the control group. Our results show that immunosuppression was accompanied by a downregulation of mRNA expression levels of selenoproteins and an upregulation of the Hsp mRNA expression levels. Thus, Se deficiency causes defects in the chicken bursa of Fabricius, and selenoproteins and Hsps play important roles in immunosuppression in the bursa of Fabricius of chickens with Se deficiency.

show abstract

Selenoproteins and maternal nutrition

Cited by 172 publications

References 184 publications

The role of organic selenium in cadmium toxicity: effects on broiler performance and health status

The role of organic selenium in cadmium toxicity: effects on broiler performance and health status

Dietary lycopenes, selenium compounds and fish oil affect the profile of fatty acids and oxidative stress in chicken breast muscle

Selenoproteins and heat shock proteins play important roles in immunosuppression in the bursa of Fabricius of chickens with selenium deficiency

Contact Info

Product

Resources

About