Selenoproteins in parasites

Salinas, Gustavo; Lobanov, Alexey V.; Gladyshev, Vadim N.

doi:10.1007/0-387-33827-6_31

Cited by 2 publications

(1 citation statement)

References 26 publications

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“…The exact mechanism(s) behind this pattern is not clear. However, as parasites, including nematodes, need Se for growth and metabolism, 40 it is likely that some Se-Met supplied to trout via diet was taken up by R. acus and thus was not available for (re)uptake (see Sures and Siddall 12 ) by the fish host. As the current study demonstrated, Se concentration in R. acus increased with time confirming continuous Se-Met uptake by the parasite.…”

Section: ■ Resultsmentioning

confidence: 99%

Intestinal Nematodes Affect Selenium Bioaccumulation, Oxidative Stress Biomarkers, and Health Parameters in Juvenile Rainbow Trout (Oncorhynchus mykiss)

Hursky

Pietrock

2015

Environ. Sci. Technol.

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In environmental studies, parasites are often seen as a product of enhanced host susceptibility due to exposure to one or several stressors, whereas potential consequences of infections on host responses are often overlooked. Therefore, the present study focused on effects of parasitism on bioaccumulation of selenium (Se) in rainbow trout (Oncorhynchus mykiss). Joint effects of biological (parasite) and chemical (Se) stressors on biomarkers of oxidative stress (glutathione-S-transferase (GST), superoxide dismutase (SOD)), and fish health (condition factor (K), hepatosomatic index (HSI), gross energy) were also examined. Fish of the control group received uncontaminated food, while test fish, either experimentally infected with the nematode Raphidascaris acus or not, were exposed to dietary selenomethionine (Se-Met) at an environmentally relevant dose over 7 weeks. Selenium bioaccumulation by the parasite was low relative to its host, and parasitized trout showed slowed Se accumulation in the muscle as compared to uninfected fish. Furthermore, GST and SOD activities of trout exposed to both Se-Met and parasites were generally significantly lower than in fish exposed to Se-Met alone. Gross energy concentrations, but not K or HSI, were reduced in fish exposed to both Se-Met and R. acus. Together the experiment strongly calls for consideration of parasites when interpreting effects of pollutants on aquatic organisms in field investigations.

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Section: ■ Resultsmentioning

confidence: 99%

Intestinal Nematodes Affect Selenium Bioaccumulation, Oxidative Stress Biomarkers, and Health Parameters in Juvenile Rainbow Trout (Oncorhynchus mykiss)

Hursky

Pietrock

2015

Environ. Sci. Technol.

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Glutathione Peroxidases

Flohé

2011

Advanced Topics in Science and Technology in China

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Background: With increasing evidence that hydroperoxides are not only toxic but rather exert essential physiological functions, also hydroperoxide removing enzymes have to be re-viewed. In mammals, the peroxidases inter alia comprise the 8 glutathione peroxidases (GPx1-GPx8) so far identified. Scope of the review: Since GPxs have recently been reviewed under various aspects, we here focus on novel findings considering their diverse physiological roles exceeding an antioxidant activity. Major conclusions: GPxs are involved in balancing the H 2 O 2 homeostasis in signalling cascades, e.g. in the insulin signalling pathway by GPx1; GPx2 plays a dual role in carcinogenesis depending on the mode of initiation and cancer stage; GPx3 is membrane associated possibly explaining a peroxidatic function despite low plasma concentrations of GSH; GPx4 has novel roles in the regulation of apoptosis and, together with GPx5, in male fertility. Functions of GPx6 are still unknown, and the proposed involvement of GPx7 and GPx8 in protein folding awaits elucidation. General significance: Collectively, selenium-containing GPxs (GPx1-4 and 6) as well as their non-selenium congeners (GPx5, 7 and 8) became key players in important biological contexts far beyond the detoxification of hydroperoxides. This article is part of a Special Issue entitled Cellular functions of glutathione.

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Selenoproteins in parasites

Cited by 2 publications

References 26 publications

Intestinal Nematodes Affect Selenium Bioaccumulation, Oxidative Stress Biomarkers, and Health Parameters in Juvenile Rainbow Trout (Oncorhynchus mykiss)

Intestinal Nematodes Affect Selenium Bioaccumulation, Oxidative Stress Biomarkers, and Health Parameters in Juvenile Rainbow Trout (Oncorhynchus mykiss)

Glutathione Peroxidases

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