Selenylated-oxadiazoles as promising DNA intercalators: Synthesis, electronic structure, DNA interaction and cleavage

Abstract

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Selenylated Imidazo[1,2-a]pyridine Induces Cell Senescence and Oxidative Stress in Chronic Myeloid Leukemia Cells

“…Thus, considering our continuous interest in the synthesis of organoselenium compounds with biological relevance and functionalization of IPs [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ], the main goal of the present research is the quest for new drugs for the treatment of CML. Considering that oxidative stress, induction of apoptosis, and senescence are crucial processes involved in the response of cancer cells to therapy, we used IP and its chalcogen derivatives in leukemic cell lines to investigate their antitumor effects with an interest in potential chemotherapeutic activity against the CML.…”

Versatile Electrochemical Synthesis of Selenylbenzo[b]Furan Derivatives Through the Cyclization of 2-Alkynylphenols

“…Similarly, the construction of the C–Se bond is among the important transformation in organic synthesis ( Rafique et al, 2016b ; Rafique et al, 2021 ), mainly due to their properties such as synthetic intermediates in organic transformations ( Shao et al, 2019 ; Arora et al, 2021 ) and material sciences ( Li et al, 2020 ) as well as in the medicinal chemistry ( Nogueria et al, 2021 ). In the past few decades, these compounds have gained increasing interest, mainly due to their antioxidant ( Mugesh and Singh 2000 ; Botteselle et al, 2021 ), anti-Alzheimer ( Rodrigues et al, 2018 ; Scheide et al, 2020b ; Kumawat et al, 2021 ), anti-inflammatory ( He et al, 2021 ), antitumor ( Spengler et al, 2019 ; Chen et al, 2020 ; Dos Santos et al, 2021 ; Santos et al, 2022 ), antiviral ( Ali et al, 2021 ), and other biological activities ( Wang et al, 2016 ; Frizon et al, 2020 ; Rafique et al, 2020 ; Galant et al, 2021 ; Martín-Escolano et al, 2021 ; Veloso et al, 2021 ).…”

Catalytic Antioxidant Activity of Bis-Aniline-Derived Diselenides as GPx Mimics

“…Recently, we reported a new robust methodology for the synthesis of o -aniline-derived diselenides from the reduction of o -nitrobenzene diselenides. As part of our wider research program aimed at efficient methodologies for the synthesis of organoselenium compounds and their biological evaluation [ 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 ], herein, we report the application of o -aniline-derived diselenides as potential GPx mimics. For this purpose, different physical-chemical studies were performed to demonstrate their biological properties, i.e., kinetic profile.…”