Self-adaptive nanoassembly enabling turn-on hypoxia illumination and periphery/center closed-loop tumor eradication

Wang, Ziyue; Zhang, Shenwu; Kong, Zhiqiang; Li, Songhao; Sun, Jun; Zhang, He; Hao, Yue; Luo, Cong

doi:10.1016/j.xcrm.2023.101014

Cited by 14 publications

(5 citation statements)

References 44 publications

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“…Advancements in “smart” fluorescent nanoprobes that switch between “on” and “off” states have garnered significant attentions 58 , 121 . Unlike “always-on” fluorescent nanoprobes, “turn-on” fluorescent nanoprobes can be selectively activated by endogenous inflammatory triggers, such as endogenous hydrogen peroxide (H 2 O 2 ) and hydrogen sulfide (H 2 S), enhancing both the sensitivity of biosensors and bioimaging resolution 122 .…”

Section: Nanotechnology-assisted Inflammation Diagnosismentioning

confidence: 99%

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Nanotechnology in inflammation: cutting-edge advances in diagnostics, therapeutics and theranostics

Liu,

Lin,

Wang

et al. 2024

Theranostics

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Inflammatory dysregulation is intimately associated with the occurrence and progression of many life-threatening diseases. Accurate detection and timely therapeutic intervention on inflammatory dysregulation are crucial for the effective therapy of inflammation-associated diseases. However, the clinical outcomes of inflammation-involved disorders are still unsatisfactory. Therefore, there is an urgent need to develop innovative anti-inflammatory strategies by integrating emerging technological innovations with traditional therapeutics. Biomedical nanotechnology is one of the promising fields that can potentially transform the diagnosis and treatment of inflammation. In this review, we outline recent advances in biomedical nanotechnology for the diagnosis and treatment of inflammation, with special attention paid to nanosensors and nanoprobes for precise diagnosis of inflammation-related diseases, emerging anti-inflammatory nanotherapeutics, as well as nanotheranostics and combined anti-inflammatory applications. Moreover, the prospects and challenges for clinical translation of nanoprobes and anti-inflammatory nanomedicines are highlighted.

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Section: Nanotechnology-assisted Inflammation Diagnosismentioning

confidence: 99%

“…Nanotechnology has been widely applied in biomedicine, especially for developing nano-DDSs to treat inflammation-related diseases 53 - 58 . The size, surface charge and shape of nanoparticles (NPs) are crucial factors that affect their interactions with biological systems 59 .…”

Section: Introductionmentioning

confidence: 99%

Nanotechnology in inflammation: cutting-edge advances in diagnostics, therapeutics and theranostics

Liu,

Lin,

Wang

et al. 2024

Theranostics

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“…Over decades, biomedical nanotechnology has greatly changed drug delivery patterns by improving undesirable properties of drugs, overcoming delivery barriers, and endowing drugs with targeting and smart delivery characteristics [34,35]. Signi cantly, nanomedicines not only enrich drug delivery modalities for a single drug, but also provide versatile co-delivery nanoplatforms for multimodal cancer therapy [36,37]. However, despite the huge potential of nanotherapeutics, carrier material-based co-delivery nanomedicines face certain challenges in drug co-loading and co-delivery in vivo [38,39].…”

Section: Introductionmentioning

confidence: 99%

One-stone-two-birds Nano-cocktail Enables Cancer Cells/Stem Cells Dual Depletion and Efficacy/Toxicity Benefit Maximization in Breast Cancer Therapy

Zhao,

Chen,

Yuan

et al. 2024

Preprint

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Background: Cancer stem cells (CSCs) are recognized as the culprits of chemoresistance, tumor metastasis and relapse. Conventional chemotherapeutic drugs not only fail to effectively kill CSCs, but induce the acquisition of stemness characteristics in non-stem cancer cells. Meanwhile, most anti-CSCs drugs display marginal inhibitory effects on cancer cell proliferation. Therefore, developing a cancer cells/CSCs double-killing modality is highly desired. Methods: A carrier-free nano-cocktail is developed through precise co-assembly of a redox-responsive dimeric prodrug of docetaxel (DTX) and salinomycin (SAL, an anti-CSCs drug) for breast cancer treatment. In this study, we systematically investigated the co-assembly mechanism, reduction-responsive drug release behavior, cellular uptake efficiency, synergistic cytotoxicity, and anti-CSCs efficacy of the nano-cocktail through in vitro experiments. Additionally, the pharmacokinetics, biodistribution and synergistic anti-tumor/CSCs activity were explored in vivo. Results: Precision combination of DTX and SAL not only shows synergistic tumor killing activity, but also sharply reduces the proportion of CSCs in tumors. More importantly, tumor-specific prodrug activation-initiated drug release confers high drug co-delivery efficiency and low off-target toxicity risk to the nano-cocktail. As expected, such a one-stone-two-birds nanomedicine has excellent performance on tumor stemness depletion, antitumor responses, and treatment safety in a breast cancer mouse xenograft model. Conclusion: This study advances cancer cells/CSCs double-killing nanotherapeutics towards clinical breast cancer therapy.

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“…, acid responsiveness) shows great promise for controlling drug release and mitigating the cytotoxicity of chemotherapeutic drugs. 21…”

Section: Introductionmentioning

confidence: 99%

Natural gambogic acid-tuned self-assembly of nanodrugs towards synergistic chemophototherapy against breast cancer

Lin,

Peng,

Cheng

et al. 2024

J. Mater. Chem. B

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Self-adaptive nanoassembly enabling turn-on hypoxia illumination and periphery/center closed-loop tumor eradication

Cited by 14 publications

References 44 publications

Nanotechnology in inflammation: cutting-edge advances in diagnostics, therapeutics and theranostics

Nanotechnology in inflammation: cutting-edge advances in diagnostics, therapeutics and theranostics

One-stone-two-birds Nano-cocktail Enables Cancer Cells/Stem Cells Dual Depletion and Efficacy/Toxicity Benefit Maximization in Breast Cancer Therapy

Natural gambogic acid-tuned self-assembly of nanodrugs towards synergistic chemophototherapy against breast cancer

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