Self‐administered daylight‐activated photodynamic therapy for the treatment of hand eczema: A prospective proof‐of‐concept study

Kremer, Noa; Sherman, Shany; Lapidoth, Moshe; Enk, Claes D.; Leshem, Yael Anne; Mimouni, Tomer; Dudkiewicz, Dean; Hodak, Emmilia; Levi, Assi

doi:10.1111/dth.14329

Cited by 6 publications

(6 citation statements)

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“…After three sessions, one every other week, a reduction of the lichenification was observed, and the skin began to heal ( Pozzi and Asero, 2010 ). More recently, daylight PDT with 5-aminolevulinic acid gel (Ameluz) was used to treat chronic hand eczema, half of them for atopic dermatitis ( Kremer et al, 2020 ). After three treatments at 2 week intervals, all the patients showed a significant clinical improvement and also in the quality of life, without significant side effects.…”

Section: Future Perspectives For the Antistaphylococcal Treatmentmentioning

confidence: 99%

Colonization With Staphylococcus aureus in Atopic Dermatitis Patients: Attempts to Reveal the Unknown

et al. 2021

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Atopic dermatitis (AD) patients are massively colonized with Staphylococcus aureus (S. aureus) in lesional and non-lesional skin. A skin infection may become systemic if left untreated. Of interest, the incidence of multi-drug resistant S. aureus (MRSA) in AD patients is higher as compared to a healthy population, which makes treatment even more challenging. Information on the specific genetic background of S. aureus accompanying and/or causing AD flares would be of great importance in terms of possible treatment option development. In this review, we summarized the data on the prevalence of S. aureus in general in AD skin, and the prevalence of specific clones that might be associated with flares of eczema. We put our special interest in the presence and role of staphylococcal enterotoxins as important virulence factors in the epidemiology of AD-derived S. aureus. Also, we summarize the present and potentially useful future anti-staphylococcal treatment.

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Section: Future Perspectives For the Antistaphylococcal Treatmentmentioning

confidence: 99%

Colonization With Staphylococcus aureus in Atopic Dermatitis Patients: Attempts to Reveal the Unknown

et al. 2021

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“…8 DL-PTD can be easily self-administered without professional assistance: treatment is completed within a single day and can be repeated at 3, 6, or 12 months of follow-up as deemed necessary, depending on the disease course. 9 In conclusion, self-administered DL-PDT is an effective and safe technique that can be useful in patients who require this treatment periodically. Individualizing each case can help decentralize care from the hospital setting and simultaneously empower patients.…”

Section: Discussionmentioning

confidence: 92%

“…A systematic review of patient‐reported outcomes following topical treatment of AK found that treatment adherence, patient satisfaction, and improvement in overall quality of life were better with simpler and shorter duration treatment regimens 8 . DL‐PTD can be easily self‐administered without professional assistance: treatment is completed within a single day and can be repeated at 3, 6, or 12 months of follow‐up as deemed necessary, depending on the disease course 9 …”

Section: Discussionmentioning

confidence: 99%

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Fully home‐based methyl aminolevulinate daylight photodynamic therapy for actinic keratosis of the face or scalp: A real life open study

García‐Gil

Gracia‐Cazaña

Cerro-Muñoz

et al. 2022

Dermatologic Therapy

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Methyl aminolevulinate daylight photodynamic therapy (MAL DL-PDT) is highly efficacious for the treatment of nonhyperkeratotic actinic keratosis (AK), even when partially performed at home. To evaluate the long-term effectiveness, safety, and patient-reported outcomes of MAL DL-PDT performed completely by the patient in real life conditions. An open prospective study was conducted in Spain among patients diagnosed with at least five AK lesions on the face or the scalp. Patients received instruction and information in infographic format to perform MAL DL-PDT at home. All had been treated with 30% urea daily for 7 days before the day of MAL DL-PDT. Meteorological conditions on the day of the treatment and adverse effects were recorded. Patients underwent follow-up, and a second session of home-based MAL DL-PDT if deemed necessary, 3, 6, and 12 months after the initial treatment session. The study population consisted of 22 patients (19 men and three women, mean [standard deviation, SD] age, 72.05 [6.96] years). A complete response was observed in 47.7% of AK lesions at 3 months (p < 0.001) and 65.9% (n = 199) at 12 months (p < 0.001). Olsen grade II lesions showed the highest rate of response (76.07% at 12 months). The mean (SD) actinic keratosis area and severity index score decreased significantly from 4.99 (2.43) at baseline to 2.33 (1.01) at 12 months (p = 0.0234). Adverse effects were mild and expected. A majority of patients were "satisfied" or "very satisfied" with the treatment instruction provided (90.9%) and the treatment outcome (72.7%). MAL DL-PDT can be applied at home like any other topical treatment for AK. Our results indicate good long-term effectiveness, a high level of patient satisfaction, and no significant side effects.

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“…PDT is non-invasive, and, in addition, the light stream can be focused on the target area thus avoiding the irradiation of healthy locations. Thus, PDT has been used in various medical procedures, such as dental procedures [8], dermatological problems [9,10], or in cancer treatment [11,12]. PDT is also used to inactivate different bacterial pathogens including uropathogenic strains [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

The Enhancement of the Photodynamic Therapy and Ciprofloxacin Activity against Uropathogenic Escherichia coli Strains by Polypodium vulgare Rhizome Aqueous Extract

2021

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Antibiotic therapy and photodynamic therapy (PDT) are commonly used to treat bacterial infections. Unfortunately, these methods are often ineffective. Therefore, agents that could effectively support antibiotic therapy and PDT in the inactivation of pathogens are being sought. Phytotherapy seems to be a good solution. The aim of the current research was to examine whether Polypodium vulgare extract (PvE) would improve the effectiveness of PDT and ciprofloxacin (CIP), an antibiotic that is commonly used to treat urinary tract infections in humans. UHPLC-MS analysis was performed to establish the PvE content. Chlorin e6 has been used as a photosensitizer in the PDT method. Biofilm production was established using the spectrophotometric method. The live cell count in planktonic and biofilm consortia was determined with the microdilution method and DAPI staining. The decrease of the bacterial survival, biofilm mass synthesis, and morphological changes of the bacteria under the combined treatments: PDT+PvE and CIP+PvE was noted. The results clearly indicate that the PvE can be used as a good agent for improving the efficacy of both PDT and the CIP activity to inactivate uropathogenic Escherichia coli strains. The obtained results are of particular value in the era of widespread and still-increasing drug resistance among bacterial pathogens.

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Self‐administered daylight‐activated photodynamic therapy for the treatment of hand eczema: A prospective proof‐of‐concept study

Abstract: Photodynamic therapy (PDT), traditionally used in patients with nonmelanoma skin cancer, has been found to be effective for various inflammatory skin conditions.

Cited by 6 publications

References 14 publications

Colonization With Staphylococcus aureus in Atopic Dermatitis Patients: Attempts to Reveal the Unknown

Colonization With Staphylococcus aureus in Atopic Dermatitis Patients: Attempts to Reveal the Unknown

Fully home‐based methyl aminolevulinate daylight photodynamic therapy for actinic keratosis of the face or scalp: A real life open study

The Enhancement of the Photodynamic Therapy and Ciprofloxacin Activity against Uropathogenic Escherichia coli Strains by Polypodium vulgare Rhizome Aqueous Extract

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