“…10 Sagan argued that cannabis use, in moderation, was safe and beneficial in healthy people 10 Importantly, whilst Sagan may have felt cannabis helped produce 'serenity and insight', more contemporary evidence suggests it may also cause the opposite to this including disturbed memory and judgement, anxiety and psychosis. 15,16 Iconic American inventor, computer pioneer and founder of Apple, Steve Jobs, allegedly told his biographer that, 'taking LSD was a profound experience, one of the most important things in my life'. 11 He appeared to attribute much of his entrepreneurial success to the mental state enhancements provided by the drug: '[LSD] reinforced my sense of what was importantcreating great things instead of making money…' 11 It is important to note that Jobs' biographer had also described him as being 'depressed' at least once and described his personality in a way suggestive of high trait openness to experienceboth aspects of his personal history that may have contributed to his use of tryptamines.…”