Self-aligned 3D microlenses in a chip fabricated with two-photon stereolithography for highly sensitive absorbance measurement

Tang, Jiukai; Qiu, Guangyu; Cao, Xiaobao; Yue, Yang; Zhang, Xiaole; Wang, Jing

doi:10.1039/d0lc00235f

Cited by 11 publications

(25 citation statements)

References 37 publications

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“…The details of the simulation method can be found elsewhere. 31 The optical response with a dimensionless arbitrary unit (AU) is defined as the logarithmic ratio between the test light intensity (I t ) and the reference light intensity (I r ), as described in eqn (1). The test and reference light intensities correspond to the detection channel filled with the test samples and ultrapure water, respectively.…”

Section: Simulation Methodsmentioning

confidence: 99%

“…More detailed information on the chip fabrication can be found elsewhere. 31 Fig. 1b shows the schematic of the entire sensing system, which consists of an MNWHD2 white light LED (Thorlabs, Newton, USA), FG105UCA multimode optical fibers (Thorlabs, Newton, USA), an optofluidic chip 3DCMOC and a ULS2048LTEC spectrometer (Avantes, Apeldoorn, Netherlands).…”

Section: Chip Fabricationmentioning

confidence: 99%

“…Microlenses as fundamental optical components have boosted a large number of on-chip applications. [27][28][29][30][31][32] Compared with solid microlenses possessing fixed optical properties, optofluidic microlenses show unparalleled tunability by easily changing the cavity medium with desired RI values or adjusting the flow rate of multiple working fluids. [27][28][29][32][33][34] Such tunability forms the foundation of RI sensing using optofluidic microlenses.…”

Section: Introductionmentioning

confidence: 99%

“…36 Cao et al used two-photon stereolithography to fabricate a lens-mirror system for high-throughput droplet detection. 37 In our previous work, 31,38 we fabricated two in-plane 3D microlenses using two-photon stereolithography to reduce the light loss for sensitive absorbance measurements. Therefore, two-photon stereolithography is an ideal technology to fabricate cascaded 3D in-plane microlenses.…”

Section: Introductionmentioning

confidence: 99%

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A 3D-cascade-microlens optofluidic chip for refractometry with adjustable sensitivity

et al. 2021

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Section: Simulation Methodsmentioning

confidence: 99%

Section: Chip Fabricationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A 3D-cascade-microlens optofluidic chip for refractometry with adjustable sensitivity

et al. 2021

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“…The microlens optical axis either lies parallel in the plane of the chip (II) or perpendicular to it (Ʇ). It is also possible to subdivide microlenses into additionally assembled and self-aligned in terms of their positioning on the chip during the manufacturing process [ 334 ]. Additionally, assembled lenses require alignment, as self-aligned lenses are immediately integrated into the chip at a fixed location and can be performed in a single technique with the chip [ 335 ].…”

Section: Label-free Optical Techniques Of Protein Detection Quantific...mentioning

confidence: 99%

Label-Free Physical Techniques and Methodologies for Proteins Detection in Microfluidic Biosensor Structures

et al. 2022

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Proteins in biological fluids (blood, urine, cerebrospinal fluid) are important biomarkers of various pathological conditions. Protein biomarkers detection and quantification have been proven to be an indispensable diagnostic tool in clinical practice. There is a growing tendency towards using portable diagnostic biosensor devices for point-of-care (POC) analysis based on microfluidic technology as an alternative to conventional laboratory protein assays. In contrast to universally accepted analytical methods involving protein labeling, label-free approaches often allow the development of biosensors with minimal requirements for sample preparation by omitting expensive labelling reagents. The aim of the present work is to review the variety of physical label-free techniques of protein detection and characterization which are suitable for application in micro-fluidic structures and analyze the technological and material aspects of label-free biosensors that implement these methods. The most widely used optical and impedance spectroscopy techniques: absorption, fluorescence, surface plasmon resonance, Raman scattering, and interferometry, as well as new trends in photonics are reviewed. The challenges of materials selection, surfaces tailoring in microfluidic structures, and enhancement of the sensitivity and miniaturization of biosensor systems are discussed. The review provides an overview for current advances and future trends in microfluidics integrated technologies for label-free protein biomarkers detection and discusses existing challenges and a way towards novel solutions.

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A Soft Sensor for Bleeding Detection in Colonoscopies

Gerald

McCandless

Sheth

et al. 2022

Advanced Intelligent Systems

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Colonoscopies allow surgeons to detect common diseases, that is, colorectal cancer, ulcers, and other ailments. However, there is a risk of bleeding in the lower gastrointestinal (GI) tract while maneuvering endoscopes. This may be due to perforations, hemorrhaging, polyps, diverticula, or post‐biopsy complications. Thus, it is essential for the surgeon to be able to detect bleeding at the site and evaluate the severity of blood leakage. Herein, a soft sensor that can detect the presence of blood at the bleeding site during colonoscopies is presented. The sensor consists of optical waveguides that interface with a microfluidic channel. Blood flow causes absorption and scattering of incident light that can be picked up by the optical sensing apparatus via light transmission through the waveguide. The surgeon can be alerted when bleeding occurs through a graphical user interface. The device is compact and measures only 1 mm thick. This allows the sensor to be circumferentially mounted onto a colonoscope at different locations. The sensor is able to record the presence of blood as an optical loss, rapidly detect the presence of blood under 100 ms as it enters the microchannel, and differentiate between gastric fluid and blood through changes in measured optical loss.

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Self-aligned 3D microlenses in a chip fabricated with two-photon stereolithography for highly sensitive absorbance measurement

Abstract: 3D microlenses (in plane) via mold replication were incorporated in the microfluidic chip for improving the performance of absorbance measurements.

Cited by 11 publications

References 37 publications

A 3D-cascade-microlens optofluidic chip for refractometry with adjustable sensitivity

A 3D-cascade-microlens optofluidic chip for refractometry with adjustable sensitivity

Label-Free Physical Techniques and Methodologies for Proteins Detection in Microfluidic Biosensor Structures

A Soft Sensor for Bleeding Detection in Colonoscopies

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