Self and Informant Memory Reports in FINGER: Associations with Two-Year Cognitive Change

Vaskivuo, Laura; Hokkanen, Laura; Hänninen, Tuomo; Antikaínen, Riitta; Bäckman, Lars; Laatikainen, Tiina; Paajanen, Teemu; Stigsdotter-Neely, Anna; Strandberg, Timo; Tuomilehto, Jaakko; Kivipelto, Miia; Ngandu, Tiia

doi:10.3233/jad-190133

Cited by 7 publications

(4 citation statements)

References 51 publications

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“…Several studies showed that a higher informant report was linked to greater cognitive deficits and longitudinal cognitive or clinical decline in cognitively unimpaired (CU) older individuals [5][6][7][8][9] and patients with mild cognitive impairment (MCI) 5,[9][10][11] or Alzheimer-type dementia (AD dementia) 11 ; while other studies found no link between the informant report and the risk of cognitive or clinical decline in various settings. 6,10,12 Part of this discrepancy might reflect the fact that the informant report clinical relevance varies according to the clinical group, as shown for the self-report measure. 13 Studies are sparse regarding the association between the informant report and Alzheimer disease biomarkers; overall, they reported a link between a higher informant report and lower amyloid β42, higher p-tau/t-tau CSF levels, 4,14,15 higher global amyloid-PET 4 and parietal tau-PET, 16 and lower hippocampal volume 4,17 and temporo-parietal glucose metabolism.…”

Section: Trial Registration Informationmentioning

confidence: 99%

Association of the Informant-Reported Memory Decline With Cognitive and Brain Deterioration Through the Alzheimer Clinical Continuum

et al. 2023

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Background and objectives:Studies are sparse regarding the association between the informant-reported subjective memory decline (informant-report) and Alzheimer’s disease (AD) biomarkers. This study thus aimed at determining the clinical relevance of the informant-report throughout the AD clinical continuum, by assessing its specific relationships with amyloid deposition, cognition and neurodegeneration.Methods:Participants from theImagerie Multimodale de la maladie d'Alzheimer à un stade Précoce(IMAP+) primary cohort and from theAlzheimer’s Disease Neuroimaging Initiative(ADNI) replication cohort were included; all underwent multimodal neuroimaging and neuropsychological assessments. Follow-up data of IMAP+ participants over up to 36 months were also used for longitudinal analyses. The informant-report was measured respectively with the Cognitive Difficulties Scale (IMAP+) and Everyday Cognition (ADNI). General linear models were used to assess the cross-sectional associations between the informant-report and amyloid-PET, cognitive performances, and neurodegeneration (atrophy and hypometabolism) in Alzheimer’s-signature areas; while longitudinal links were assessed in IMAP+ with linear mixed-effects models.Results:110 IMAP+ participants were included, including 32 cognitively unimpaired elders (controls, age: 70.91±6.57, female:50%), 25 patients with subjective cognitive decline (SCD, 65.88±6.64, 40%), 35 with mild cognitive impairment (MCI, 72.49±7.5, 34%) and 18 with Alzheimer’s-type dementia (AD dementia, 68.17±8.59, 28%). 731 ADNI participants were included, including 157 controls (74.21±5.95, 55%), 84 SCD (72.00±5.41, 63%), 369 MCI (71.84±7.4, 44%) and 121 AD dementia (74.29±7.75, 40%). In IMAP+, higher informant-report strongly correlated to greater amyloid-PET specifically in MCI patients (β=0.48, p=.003), and to lower cognitive performance in SCD (global cognition, β=-0.41, p=.04) and MCI patients (memory, β=-0.37, p=.03). Findings in MCI patients were replicated in ADNI (amyloid-PET, β=0.25, p<.001; memory, β=-0.22, p<.001), and extended to neurodegeneration in AD signature areas (β=-0.2, p<.001). Longitudinal analyses in IMAP+ showed links with global cognitive decline over time in MCI (est. -0.74, SE 0.26, p=.005) and in SCD (est. -0.36, SE 0.26, p=.02) patients where higher baseline informant-report also predicted increased amyloid-PET over time (est. 0.008, SE 0.003, p=.02).Discussion:Altogether, our findings suggest that the informant-report is particularly relevant in MCI patients where it strongly relates to higher amyloid-PET, indicative of impairment due-to-AD.Trial registration information:ClinicalTrials.gov Identifier:NCT01638949

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Section: Trial Registration Informationmentioning

confidence: 99%

Association of the Informant-Reported Memory Decline With Cognitive and Brain Deterioration Through the Alzheimer Clinical Continuum

et al. 2023

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“…Fogarty (2017) [ 41 ] stated that people with mild AD had more significant concerns regarding their executive functions associated with their daily lives, an opinion which was corroborated, to a lesser extent, by their informants. However, other studies indicated that only self-reported cognitive complaints predicted future cognitive changes and were associated with executive functioning, unlike informants’ reports being associated with other cognitive processes [ 58 , 59 ].…”

Section: Discussionmentioning

confidence: 99%

The Challenge of Subjective Cognitive Complaints and Executive Functions in Middle-Aged Adults as a Preclinical Stage of Dementia: A Systematic Review

Webster-Cordero

2022

Geriatrics

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Subjective cognitive complaints correspond to a heterogeneous construct that frequently occurs in the early stages of older adult life. Despite being a common source of worry for middle-aged people, it can be underestimated when clinical and neuropsychological assessments discard any underlying pathological processes. Negative age stereotyping but also self-stereotyping can contribute to doing so. Although its diagnosis is a challenge, its implication as a possible predictor of mild cognitive impairment or dementia increases the interest in its early diagnosis and intervention. The present systematic review analyzes the empirical data on the relationship between these complaints and early executive dysfunction with possible predictive value for preclinical stages of dementia. The sixteen papers obtained from the PubMed and Embase databases were exploratory, cross-sectional and prospective in scope. The studies corroborated the relationship between subjective cognitive complaints and some executive processes, which is noteworthy since many people with subjective executive complaints progress to dementia. The relational studies confirmed that impaired executive performance is associated with CSF biomarkers and reduced cortical volume in specific brain regions. However, the heterogeneity of reports in these studies demands stronger efforts in future research with specific tools applied in clinical and neuropsychological assessments and analyzed under a gender perspective.

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“…People with SMC were diagnosed according to guidelines published in [ 39 ]. There is some evidence that self-reported SMC can predict future cognitive decline [ 61 ], but findings are controversial [ 62 ]. Thus, it remains unclear if the study population is relevant for AD or if SMC had other etiologies.…”

Section: Discussionmentioning

confidence: 99%

Learning to play golf for elderly people with subjective memory complaints: feasibility of a single‐blinded randomized pilot trial

et al. 2021

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Background Subjective Memory Complaints (SMC) in elderly people due to preclinical Alzheimer’s Disease may be associated with dysregulation of the Kynurenine Pathway (KP), with an increase in neurotoxic metabolites that affect cognition. Golf is a challenging sport with high demands on motor, sensory, and cognitive abilities, which might bear the potential to attenuate the pathological changes of preclinical AD. This trial investigated the feasibility of learning to play golf for elderly with cognitive problems and its effects on cognitive functions and the KP. Methods In a 22-week single-blinded randomized controlled trial, elderly people with SMC were allocated to the golf (n = 25, 180 min training/week) or control group (n = 21). Primary outcomes were feasibility (golf exam, adherence, adverse events) and general cognitive function (Alzheimer’s Disease Assessment Scale). Secondary outcomes include specific cognitive functions (Response Inhibition, Corsi Block Tapping Test, Trail Making Test), KP metabolites and physical performance (6-Minute-Walk-Test). Baseline-adjusted Analysis-of-Covariance was conducted for each outcome. Results 42 participants were analyzed. All participants that underwent the golf exam after the intervention passed it (20/23). Attendance rate of the golf intervention was 75 %. No adverse events or drop-outs related to the intervention occurred. A significant time*group interaction (p = 0.012, F = 7.050, Cohen’s d = 0.89) was found for correct responses on the Response Inhibition task, but not for ADAS-Cog. Moreover, a significant time*group interaction for Quinolinic acid to Tryptophan ratios (p = 0.022, F = 5.769, Cohen’s d = 0.84) in favor of the golf group was observed. An uncorrected negative correlation between attendance rate and delta Quinolinic acid to Kynurenic acid ratios in the golf group (p = 0.039, r=-0.443) was found as well. Conclusions The findings indicate that learning golf is feasible and safe for elderly people with cognitive problems. Preliminary results suggest positive effects on attention and the KP. To explore the whole potential of golfing and its effect on cognitive decline, a larger cohort should be studied over a longer period with higher cardiovascular demands. Trial registration The trial was retrospectively registered (2nd July 2018) at the German Clinical Trials Register (DRKS00014921).

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Self and Informant Memory Reports in FINGER: Associations with Two-Year Cognitive Change

Cited by 7 publications

References 51 publications

Association of the Informant-Reported Memory Decline With Cognitive and Brain Deterioration Through the Alzheimer Clinical Continuum

Association of the Informant-Reported Memory Decline With Cognitive and Brain Deterioration Through the Alzheimer Clinical Continuum

The Challenge of Subjective Cognitive Complaints and Executive Functions in Middle-Aged Adults as a Preclinical Stage of Dementia: A Systematic Review

Learning to play golf for elderly people with subjective memory complaints: feasibility of a single‐blinded randomized pilot trial

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