Self- and Informant-Reported Memory Complaints: Frequency and Severity in Cognitively Intact Individuals and those with Mild Cognitive Impairment and Neurodegenerative Dementias

Rahman‐Filipiak, Annalise; Giordani, Bruno; Heidebrink, Judith L.; Bhaumik, Arijit; Hampstead, Benjamin M.

doi:10.3233/jad-180083

Cited by 20 publications

(28 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on typical cognitive symptoms of AD and related dementia, we hypothesized that measures of fluid ability (i.e., declarative memory, executive functioning, attention, and processing speed) from the CBB and NIHTB-CB would most strongly differentiate between diagnosis groups as compared to measures of crystallized ability (e.g., vocabulary). Filipiak, Giordani, Heidebrink, Bhaumik, & Hampstead, 2018;Weintraub et al, 2018;Weintraub et al, 2009). Participants also completed the NIHTB-CB and CBB within 3 months of their NACC-UDS assessment, the results of which were not used as part of the consensus conference diagnostic process.…”

Section: Introductionmentioning

confidence: 99%

Laptop-Administered NIH Toolbox and Cogstate Brief Battery in Community-Dwelling Black Adults: Unexpected Pattern of Cognitive Performance between MCI and Healthy Controls

Kairys

Daugherty

Kavcic

et al. 2021

J Int Neuropsychol Soc

Self Cite

View full text Add to dashboard Cite

Objective: Black adults are approximately twice as likely to develop Alzheimer’s disease (AD) than non-Hispanic Whites and access diagnostic services later in their illness. This dictates the need to develop assessments that are cost-effective, easily administered, and sensitive to preclinical stages of AD, such as mild cognitive impairment (MCI). Two computerized cognitive batteries, NIH Toolbox-Cognition and Cogstate Brief Battery, have been developed. However, utility of these measures for clinical characterization remains only partially determined. We sought to determine the convergent validity of these computerized measures in relation to consensus diagnosis in a sample of MCI and healthy controls (HC). Method: Participants were community-dwelling Black adults who completed the neuropsychological battery and other Uniform Data Set (UDS) forms from the AD centers program for consensus diagnosis (HC = 61; MCI = 43) and the NIH Toolbox-Cognition and Cogstate batteries. Discriminant function analysis was used to determine which cognitive tests best differentiated the groups. Results: NIH Toolbox crystallized measures, Oral Reading and Picture Vocabulary, were the most sensitive in identifying MCI apart from HC. Secondarily, deficits in memory and executive subtests were also predictive. UDS neuropsychological test analyses showed the expected pattern of memory and executive functioning tests differentiating MCI from HC. Conclusions: Contrary to expectation, NIH Toolbox crystallized abilities appeared preferentially sensitive to diagnostic group differences. This study highlights the importance of further research into the validity and clinical utility of computerized neuropsychological tests within ethnic minority populations.

show abstract

Section: Introductionmentioning

confidence: 99%

Laptop-Administered NIH Toolbox and Cogstate Brief Battery in Community-Dwelling Black Adults: Unexpected Pattern of Cognitive Performance between MCI and Healthy Controls

Kairys

Daugherty

Kavcic

et al. 2021

J Int Neuropsychol Soc

Self Cite

View full text Add to dashboard Cite

show abstract

“…5,6 To augment the evaluation of functional status in those with cognitive impairment, a knowledgeable care partner is often consulted. There is support for the widespread use of a care partner report to accurately reflect cognitive and functional changes in Alzheimer's disease (AD), 7,8 although the quality of study partner reports vary, and care partners may overestimate functional performance specifically among those with higher cognitive scores. 9 Despite these reports in AD, to date little is known about the relationship between self and study partner reports concerning the performance of IADLs during the course of PD.…”

mentioning

confidence: 99%

Participant and Study Partner Reported Impact of Cognition on Functional Activities in Parkinson's Disease

Cholerton

Poston

Tian

et al. 2019

Movement Disord Clin Pract

View full text Add to dashboard Cite

Introduction Introduction: Cognitive dysfunction is common in Parkinson's disease (PD) and associated with reduced functional abilities and increased dependence. To date, however, little is known about the relationship between performance of instrumental activities of daily living (IADLs) and cognitive stages in PD, and there are conflicting reports as to whether declines in specific cognitive domains predict IADL impairment. Methods Methods: Participants with PD were drawn from the Pacific Udall Center and included in the study if both participant and study partner IADL ratings and cognitive tests were completed (n = 192). Logistic regression analyses were performed to determine whether participant and/or study partner rating predicted mild cognitive impairment or dementia. Correlations are reported for the relationship between participant/study partner IADL reports as well as for specific cognitive tests. ResultsResults: Although both participant and study partner ratings of IADL performance were associated with a diagnosis of PD with dementia, only participant self-rating of functional ability was significantly associated with a diagnosis of PD with mild cognitive impairment. Functional ability correlated most strongly with measures of processing speed, auditory working memory, and immediate verbal recall for both the participant and study partner ratings. Conclusion Conclusion: For participants with PD in the early stages of cognitive decline, self-rating may be more sensitive to the impact of cognitive changes on IADL function than ratings made by a knowledgeable study partner. Changes in executive function, processing speed, and learning may indicate a higher likelihood of IADL impairment. Careful assessment of cognition and IADL performance is recommended to permit individualized interventions prior to significant disability.Cognitive impairment is pervasive in Parkinson's disease (PD), often resulting in devastating impacts on quality of life, functional performance, and independence. 1 A decline in the ability to perform instrumental activities of daily living (IADL) related to cognitive impairment, although often initially subtle, can negatively impact disease outcome if not identified and adequately compensated. 2 Although significant functional impairment may be more apparent in PD-related dementia (PDD), subtle deficits in complex IADLs occur frequently among those with PDrelated mild cognitive impairment (PD-MCI), and the presence of such deficits may help to reveal the presence of early cognitive decline. 3 The assessment of functional change in PD presents challenges, however. Performance-based measures are not often

show abstract

“…One study 34 only described overall demographic characteristics but not those concerning the patients who underwent awareness evaluation. Only one study 36 did not acknowledge the demographic characteristics of the participants. Patients attending outpatient clinics or hospitals were assessed in five of the studies, whereas only one included a community-based sample 36 .…”

Section: Sample Characteristicsmentioning

confidence: 99%

“…Only one study 36 did not acknowledge the demographic characteristics of the participants. Patients attending outpatient clinics or hospitals were assessed in five of the studies, whereas only one included a community-based sample 36 .…”

Section: Sample Characteristicsmentioning

confidence: 99%

Anosognosia in dementia with Lewy bodies: a systematic review

Calil

Sudo

Santiago-Bravo

et al. 2021

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

Background: Anosognosia, i.e. lack of awareness of one’s own symptoms, is a very common finding in patients with dementia and is related to neuropsychiatric symptoms and worse prognosis. Although dementia with Lewy bodies (DLB) is the second most common form of degenerative dementia, literature on anosognosia in this disease is scarce. Objectives: This paper aimed to review the current evidence on anosognosia in patients with DLB, including its prevalence in comparison with other neurological conditions, its severity and anatomical correlations. Methods: Database searches were performed in PubMed, Web of Knowledge and PsycINFO for articles assessing anosognosia in DLB. A total of 243 studies were retrieved, but only six were included in the review. Results: Potential risk of selection, comparison or outcome biases were detected in relation to all the studies selected. Most of the studies used self-report memory questionnaires to assess cognitive complaints and compared their results to scores from informant-based instruments or to participants’ cognitive performance in neuropsychological tasks. Subjects with DLB had worse awareness regarding memory than healthy older controls, but the results concerning differences in anosognosia between DLB and Alzheimer’s disease (AD) patients were inconsistent across studies. Presence of AD pathology and neuroimaging biomarkers appeared to increase the prevalence of anosognosia in individuals with DLB. Conclusion: Anosognosia is a common manifestation of DLB, but it is not clear how its prevalence and severity compare with AD. Co-existence of AD pathology seems to play a role in memory deficit awareness in DLB.

show abstract

Self- and Informant-Reported Memory Complaints: Frequency and Severity in Cognitively Intact Individuals and those with Mild Cognitive Impairment and Neurodegenerative Dementias

Abstract: Given greater diagnostic specificity and internal consistency of informant report, clinicians should weigh this information more heavily than self-report in the diagnostic process.

Cited by 20 publications

References 43 publications

Laptop-Administered NIH Toolbox and Cogstate Brief Battery in Community-Dwelling Black Adults: Unexpected Pattern of Cognitive Performance between MCI and Healthy Controls

Laptop-Administered NIH Toolbox and Cogstate Brief Battery in Community-Dwelling Black Adults: Unexpected Pattern of Cognitive Performance between MCI and Healthy Controls

Participant and Study Partner Reported Impact of Cognition on Functional Activities in Parkinson's Disease

Anosognosia in dementia with Lewy bodies: a systematic review

Contact Info

Product

Resources

About