Self-Assembled Aggregated Structures of Natural Products for Oral Drug Delivery

Zhong, Qiyuan; Zeng, Jingqi; Jia, Xiaobin

doi:10.2147/ijn.s467354

IJN

2024

DOI: 10.2147/ijn.s467354

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Self-Assembled Aggregated Structures of Natural Products for Oral Drug Delivery

Qiyuan Zhong,

Jingqi Zeng,

Xiaobin Jia

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2024

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Cited by 1 publication

References 106 publications

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Endocytic Uptake of Self‐Assembled Iridium(III) Nanoaggregates for Holistic Treatment of Metastatic 3D Triple‐Negative Breast Tumor Spheroids

Chaudhary,

Kumar,

Swain

et al. 2024

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Triple‐negative breast cancer (TNBC) presents a formidable challenge due to its aggressive behavior and limited array of treatment options available. This study focuses on employing nanoaggregate material of organometallic Ir(III) complexes for treating TNBC cell line MDA‐MB‐231. In this approach, Ir(III) complexes with enhanced cellular permeability are strategically designed and achieved through the incorporation of COOMe groups into their structure. The lead compound, IrL1, exhibits promiscuous nanoscale aggregation in RPMI cell culture media, characterized by a stable hydrodynamic effective diameter ranging from 190 to 202 nm over 48 h. With excellent photo‐responsive contrast‐enhanced cell imaging properties IrL1 exhibits an outstanding IC50, 48h value of 36.05± 0.03 nm when irradiated with 390 nm light in MDA‐MB‐231 (IC50, 48 h of Cisplatin is 5.29 µµ). In cell, investigation confirms that IrL1 nanoaggregates internalization via energy‐dependent endocytosis undergo ferroptosis and ROS mediated cell death in MDA‐MB‐231 cells. Further, these in vivo studies using NOD‐SCID mice confirmed that IrL1 exhibits a tendency to ablate tumors inoculated in mice models at therapeutically relevant doses. Thus, this comprehensive approach holds promise for expanding the repertoire of organometallic Ir(III) nanoaggregates with adaptable characteristics, thereby advancing their clinical utility of nanomedicine in the holistic treatment of metastatic 3D triple‐negative breast tumor spheroids.

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Endocytic Uptake of Self‐Assembled Iridium(III) Nanoaggregates for Holistic Treatment of Metastatic 3D Triple‐Negative Breast Tumor Spheroids

Chaudhary,

Kumar,

Swain

et al. 2024

Small

View full text Add to dashboard Cite

show abstract

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Self-Assembled Aggregated Structures of Natural Products for Oral Drug Delivery

Cited by 1 publication

References 106 publications

Endocytic Uptake of Self‐Assembled Iridium(III) Nanoaggregates for Holistic Treatment of Metastatic 3D Triple‐Negative Breast Tumor Spheroids

Endocytic Uptake of Self‐Assembled Iridium(III) Nanoaggregates for Holistic Treatment of Metastatic 3D Triple‐Negative Breast Tumor Spheroids

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