Since the discovery of fullerene, scanning tunneling microscopy under ultrahigh vacuum and a cryogenic temperature has been a popular method of extracting the properties of single molecules. However, some nanoelements exhibit a function based on a single-molecule property even though they are embedded in a cluster. Here, we present our experimental demonstration of fullerene resistive switching device, which can be realized in crystal nanowires (NWs). We fabricated a two-terminal device using fullerene self-assembled C60 NWs, which can be synthesized by dispersing fullerenes in a solution, keeping them in a supersaturated state, and maintaining a liquid–liquid interface. We found that the C60 NW device can be operated at room temperature and can reproducibly perform several hundred repetitive switch operations. The reproducibility of the device fabrication is high, and we expect the appearance of integrated devices based on the results of our experiments.