Self-assembled amphiphilic fluorescent probe: detecting pH-fluctuations within cancer cells and tumour tissues

Kim, Soo Yeon; Podder, Arup; Lee, Hyunseung; Cho, Youn-Joo; Han, Eun Hee; Khatun, Sabina; Sessler, Jonathan L.; Hong, Kwan Soo; Bhuniya, Sankarprasad

doi:10.1039/d0sc03795h

Cited by 33 publications

(21 citation statements)

References 46 publications

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“…Moroever, using amphiphilic sensors have high applicability for analytes that are also amphihilic in character such as glycolipids ( Xu et al, 2018 ). Specific applications that have used amphiphilic structures for sensing include bacterial detection ( Nandi et al, 2015 ) or assessment of pH-fluctuations in cancer cells or tumor tissues ( Kim et al, 2020 ).…”

Section: Supramolecular Systems As Recognition and Reporter Units For Biosensingmentioning

confidence: 99%

Evolution of Supramolecular Systems Towards Next-Generation Biosensors

2021

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Supramolecular materials, which rely on dynamic non-covalent interactions, present a promising approach to advance the capabilities of currently available biosensors. The weak interactions between supramolecular monomers allow for adaptivity and responsiveness of supramolecular or self-assembling systems to external stimuli. In many cases, these characteristics improve the performance of recognition units, reporters, or signal transducers of biosensors. The facile methods for preparing supramolecular materials also allow for straightforward ways to combine them with other functional materials and create multicomponent sensors. To date, biosensors with supramolecular components are capable of not only detecting target analytes based on known ligand affinity or specific host-guest interactions, but can also be used for more complex structural detection such as chiral sensing. In this Review, we discuss the advancements in the area of biosensors, with a particular highlight on the designs of supramolecular materials employed in analytical applications over the years. We will first describe how different types of supramolecular components are currently used as recognition or reporter units for biosensors. The working mechanisms of detection and signal transduction by supramolecular systems will be presented, as well as the important hierarchical characteristics from the monomers to assemblies that contribute to selectivity and sensitivity. We will then examine how supramolecular materials are currently integrated in different types of biosensing platforms. Emerging trends and perspectives will be outlined, specifically for exploring new design and platforms that may bring supramolecular sensors a step closer towards practical use for multiplexed or differential sensing, higher throughput operations, real-time monitoring, reporting of biological function, as well as for environmental studies.

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Section: Supramolecular Systems As Recognition and Reporter Units For Biosensingmentioning

confidence: 99%

Evolution of Supramolecular Systems Towards Next-Generation Biosensors

2021

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“…Se ha identificado la variación del pH de células cancerosas y tejidos tumorales con una sonda a base de 1,8-naftalimida (Kim, et al, 2020) (Figura 9F), la cual, tras la reducción del pH, se observa un aumento de la intensidad de fluorescencia a 531 nm, debido al bloqueo de un mecanismo PET, a causa de la protonación de los átomos de nitrógeno donantes presentes en la molécula.…”

Section: Figura 9 Sondas Con Aplicación Médico-biológicaunclassified

Sondas fluorescentes, una revisión general: propiedades, diseño y aplicaciones

Briones-Vázquez¹,

Álvarez‐Hernández²

2021

ICBI

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Las sondas fluorescentes son compuestos químicos que presentan el fenómeno óptico de fluorescencia y son utilizados en la detección cualitativa y/o cuantitativa de una gran variedad de analitos. En consecuencia, se han convertido en una herramienta eficiente para la obtención de información dinámica sobre la localización y cuantificación de moléculas de interés. En este artículo, se describen conceptos generales alrededor de las sondas fluorescentes: historia, propiedades químicas y físicas, equipos de detección, características estructurales para el diseño y síntesis, mecanismos de acción frente a los analitos y algunas aplicaciones en el área de polímeros (elucidación de mecanismos, determinación de cinética, observación de cambios de morfología, etc.), en la obtención de imagen de tejidos y/o células en tiempo real en el área médico-biológica y en la detección de especies químicas potencialmente tóxicos, relacionados con la contaminación del medio ambiente

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“…The changes of pH and viscosity in cells will affect the reaction rate and material and energy transfer rates of cells, which have important biological value for the analysis of various physiological activities of cells (Han et al, 2020 ; Kim et al, 2020 ; Ma et al, 2020 ; Zhang J. et al, 2020 ; Zhi et al, 2020 ). A novel AIE-active probe 3 based on a styrylquinoline derivative with excellent two-photon performance was designed and synthesized ( Figure 2B ) (Dou et al, 2019 ).…”

Section: Bioimaging Applicationsmentioning

confidence: 99%

Fluorescent AIE-Active Materials for Two-Photon Bioimaging Applications

Lü

Liu

et al. 2020

Front. Chem.

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Fluorescence imaging has been widely used as a powerful tool for in situ and real-time visualization of important analytes and biological events in live samples with remarkably high selectivity, sensitivity, and spatial resolution. Compared with one-photon fluorescence imaging, two-photon fluorescence imaging exhibits predominant advantages of minimal photodamage to samples, deep tissue penetration, and outstanding resolution. Recently, the aggregation-induced emission (AIE) materials have become a preferred choice in two-photon fluorescence biological imaging because of its unique bright fluorescence in solid and aggregate states and strong resistance to photobleaching. In this review, we will exclusively summarize the applications of AIE-active materials in two-photon fluorescence imaging with some representative examples from four aspects: fluorescence detection, in vitro cell imaging, ex vivo tissue imaging, and in vivo vascular imaging. In addition, the current challenges and future development directions of AIE-active materials for two-photon bioimaging are briefly discussed.

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Self-assembled amphiphilic fluorescent probe: detecting pH-fluctuations within cancer cells and tumour tissues

Abstract: A self-assembled amphiphilic fluorescent probe allows pH-fluctuations within cancer cells and tumour tissues to be readily detected.

Cited by 33 publications

References 46 publications

Evolution of Supramolecular Systems Towards Next-Generation Biosensors

Evolution of Supramolecular Systems Towards Next-Generation Biosensors

Sondas fluorescentes, una revisión general: propiedades, diseño y aplicaciones

Fluorescent AIE-Active Materials for Two-Photon Bioimaging Applications

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