2020
DOI: 10.1002/anie.201915287
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Self‐Assembled Artificial Ion‐Channels toward Natural Selection of Functions

Abstract: Owing to their significant physiological functions, especially as selective relays for translocation of physiological relevant species through cellular membranes, natural ion channels play important role in the living organisms. During the last decades, the field of self‐assembled ion channels has been continuously developed. Convergent multidimensional self‐assembly strategies have been used for the synthesis of unimolecular channels or non‐covalent self‐organized channels, designed to mimic natural ion chann… Show more

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Cited by 167 publications
(87 citation statements)
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References 211 publications
(261 reference statements)
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“…The transport is regulated by proteins, converting the ion‐water interactions into ion‐selectivity filter ones [2] . Because of the high significance of the related processes, the design of synthetic unimolecular or self‐assembled channels with water‐ion [3] or ion‐ion [4, 5] selectivity have become areas of expanding interest. Very attractive strategies have been developed based on the self‐assembly, towards supramolecular capsules presenting conductance states in bilayer membranes.…”
Section: Figurementioning
confidence: 99%
“…The transport is regulated by proteins, converting the ion‐water interactions into ion‐selectivity filter ones [2] . Because of the high significance of the related processes, the design of synthetic unimolecular or self‐assembled channels with water‐ion [3] or ion‐ion [4, 5] selectivity have become areas of expanding interest. Very attractive strategies have been developed based on the self‐assembly, towards supramolecular capsules presenting conductance states in bilayer membranes.…”
Section: Figurementioning
confidence: 99%
“…Therefore, ion transport through membrane is actually a supramolecular function (Fyles, 2007 ). Inspired by the functional sophistication of ion transporters in nature, supramolecular chemists have created a variety of synthetic systems to replicate the transport functions by using small molecules and synthetic compounds (Kim and Sessler, 2015 ; Si et al, 2015 ; Chen et al, 2018a , b , 2020 ; Wu et al, 2018 ; Zhang et al, 2019 ; Zheng et al, 2020 ). It is of biological importance to build artificial ion transporters with desired properties, which will not only help to elucidate the possible mechanism by biological transporters, but also to provide early diagnosis and potential medical applications for the treatment of diseases caused by structural and functional abnormalities (such as “channelopathies”) (Zaydman et al, 2012 ).…”
Section: Introductionmentioning
confidence: 99%
“…In the design of synthetic transporters, most reported compounds have hydrophobic structures to facilitate the insertion of hydrophobic phospholipid bilayer membrane (Kim and Sessler, 2015 ; Si et al, 2015 ; Wu et al, 2018 ; Zheng et al, 2020 ). However, there are two obvious shortcomings in such a design, including the requirement of organic solvents to solute the compounds and the competitive self-precipitation in physiological solution before inserting in lipid membrane.…”
Section: Introductionmentioning
confidence: 99%
“… 7 Of the wide range of artificial ion channels developed and studied, 8 several show either cation selectivity 9 or anion selectivity. 10 However, a significant challenge in the field is to “switch” any channel activity, 11 so that, like natural examples, activity can be controlled by external stimuli, such as light or chemical messengers. Closing channels by blocking the lumen with an added ligand is known, but examples of ligand-induced channel opening are less common.…”
Section: Introductionmentioning
confidence: 99%