Self-assembled boron dipyrromethene-based nanocarriers with encapsulated doxorubicin for chemo-photodynamic therapy

Zhang, Jinjin; Jiang, Minling; Li, Yaojun; Ji, Yu; Qiu, Huayu; Gu, Meier; Li, Yang; Yin, Shouchun

doi:10.1016/j.dyepig.2022.110679

Cited by 7 publications

(5 citation statements)

References 40 publications

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“…Intratumoral injection is a practical and clinical cancer treatment strategy that enables greater drug diffusion within tumors, minimizes unwanted biodistribution, and reduces systemic toxicity and side effects [ 28 ]. Herein, we used intratumoral administration to investigate the tumor-suppressive effect of the NMe 2 NBS.…”

Section: Resultsmentioning

confidence: 99%

Manipulating the Subcellular Localization and Anticancer Effects of Benzophenothiaziniums by Minor Alterations of N-Alkylation

Chen

Yao

et al. 2023

Molecules

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Cationic, water-soluble benzophenothiaziniums have been recognized as effective type I photosensitizers (PSs) against hypoxic tumor cells. However, the study of the structure–property relationship of this type of PS is still worth further exploration to achieve optimized photodynamic effects and minimize the potential side effects. Herein, we synthesized a series of benzophenothiazine derivatives with minor N-alkyl alteration to study the effects on the structure–property relationships. The cellular uptake, subcellular organelle localization, reactive oxygen species (ROS) generation, and photocytotoxicity performances were systematically investigated. NH2NBS and EtNBS specifically localized in lysosomes and exhibited high toxicity under light with a moderate phototoxicity index (PI) due to the undesirable dark toxicity. However, NMe2NBS with two methyl substitutions accumulated more in mitochondria and displayed an excellent PI value with moderate light toxicity and negligible dark toxicity. Without light irradiation, NH2NBS and EtNBS could induce lysosomal membrane permeabilization (LMP), while NMe2NBS showed no obvious damage to lysosomes. After irradiation, NH2NBS and EtNBS were released from lysosomes and relocated into mitochondria. All compounds could induce mitochondria membrane potential (MMP) loss and nicotinamide adenine dinucleotide phosphate (NADPH) consumption under light to cause cell death. NMe2NBS exhibited remarkable in vivo photodynamic therapy (PDT) efficacy in a xenograft mouse tumor (inhibition rate, 89%) with no obvious side effects. This work provides a valuable methodology to investigate the structure–property relationships of benzophenothiazine dyes, which is of great importance in the practical application of PDT against hypoxia tumor cells.

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Section: Resultsmentioning

confidence: 99%

Manipulating the Subcellular Localization and Anticancer Effects of Benzophenothiaziniums by Minor Alterations of N-Alkylation

Chen

Yao

et al. 2023

Molecules

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“…124 Unlike direct amphiphilic macromolecule encapsulation, this approach typically involves modifying hydrophobic donors or acceptors with hydrophilic small molecules 125,126 or polymer chains. 66,127 These modified components are then assembled into SCCs, which subsequently self-assemble into nanoparticles or vesicles due to their amphiphilic nature. These hydrophilic segments can reduce the adhesion of proteins and cells to the material and shield the hydrophobic components of SCCs from hydrolysis and enzymatic degradation.…”

Section: Carrier-free Sccs Prepared By Functional Motif Modificationmentioning

confidence: 99%

“…[62][63][64] The other strategy is to chemically modify SCCs with hydrophilic groups or long chains, conferring a degree of water solubility (carrier-free). [65][66][67]…”

Section: Strategies To Improve the Water Solubility And Biostability ...mentioning

confidence: 99%

Strategies to address key challenges of metallacycle/metallacage-based supramolecular coordination complexes in biomedical applications

Xu,

Li,

Yin

et al. 2024

Chem. Soc. Rev.

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“…Some of the commonly used photosensitizers are hematoporphyrin derivative [ 76 , 77 ], 5-aminolaevulinic acid [ 78 , 79 ], boron-dipyrromethene [ 80 ], and so on. Studies have shown that the use of topical anticancer drugs along with PDT as a combinatorial approach is highly effective in skin tumor eradication [ 81 ] . The drawback associated with the technique is that high-cost and deep-rooted tumors are unable to kill effectively [ 82 ].…”

Section: Current Treatment Approaches and Their Limitationsmentioning

confidence: 99%

Advancements in nanoparticle-based treatment approaches for skin cancer therapy

et al. 2023

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Skin cancer has emerged as the fifth most commonly reported cancer in the world, causing a burden on global health and the economy. The enormously rising environmental changes, industrialization, and genetic modification have further exacerbated skin cancer statistics. Current treatment modalities such as surgery, radiotherapy, conventional chemotherapy, targeted therapy, and immunotherapy are facing several issues related to cost, toxicity, and bioavailability thereby leading to declined anti-skin cancer therapeutic efficacy and poor patient compliance. In the context of overcoming this limitation, several nanotechnological advancements have been witnessed so far. Among various nanomaterials, nanoparticles have endowed exorbitant advantages by acting as both therapeutic agents and drug carriers for the remarkable treatment of skin cancer. The small size and large surface area to volume ratio of nanoparticles escalate the skin tumor uptake through their leaky vasculature resulting in enhanced therapeutic efficacy. In this context, the present review provides up to date information about different types and pathology of skin cancer, followed by their current treatment modalities and associated drawbacks. Furthermore, it meticulously discusses the role of numerous inorganic, polymer, and lipid-based nanoparticles in skin cancer therapy with subsequent descriptions of their patents and clinical trials. Graphical Abstract

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Self-assembled boron dipyrromethene-based nanocarriers with encapsulated doxorubicin for chemo-photodynamic therapy

Cited by 7 publications

References 40 publications

Manipulating the Subcellular Localization and Anticancer Effects of Benzophenothiaziniums by Minor Alterations of N-Alkylation

Manipulating the Subcellular Localization and Anticancer Effects of Benzophenothiaziniums by Minor Alterations of N-Alkylation

Strategies to address key challenges of metallacycle/metallacage-based supramolecular coordination complexes in biomedical applications

Advancements in nanoparticle-based treatment approaches for skin cancer therapy

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