Self‐Assembled Delivery Vehicles for Poorly Water‐Soluble Drugs: Basic Theoretical Considerations and Modeling Concepts

Augmenting drug–carrier compatibility improves tumour nanotherapy efficacy

“…There is particular interest in and increasingly study of second-generation self-assembled polymeric nanoparticle platforms that allow controlled drug release, and some of these have entered clinical trials 15 16 . Such platforms typically carry chemotherapeutic agents that are physically entrapped in or attached to particles' hydrophobic cores 17 18 . However, the majority of these self-assembled structures have problems with drug-loading stability, which is strongly influenced by the in vivo environment 19 20 21 22 , in that blood components can act as competing drug acceptors 23 .…”