Self-assembled drug delivery systems

Morphological transformation of self-assembled nanostructures prepared from cholesteryl acyl didanosine and the optimal formulation of nanoparticulate systems: Effects of solvents, acyl chain length and poloxamer 188

“…Using this technology, we may overcome the above-mentioned disadvantages of traditional carriers, and produce the nanoparticulate systems having high drug loads without drug leakage. Self-assembled nanoparticulate systems of prodrugs are called self-assembled drug delivery systems (SADDS) [13]. Significantly, self-assembling prodrugs are the basis of this technology.…”

Self-assemblies of 5′-cholesteryl-ethyl-phosphoryl zidovudine

“…The degradation was much faster that in the buffered solutions and plasma. The presence of a great number of hydrolysis enzymes in the tissues may be the reason [24]. More importantly, the rapid degradation of CEPZ in the MPS was very preferred because the macrophages were the hosts of HIV.…”

“…Self-assembled drug delivery systems (SADDS) have been explored in our lab since 2001, defined as the self-assemblies of amphiphilic prodrugs, wherein three technologies involving prodrug, molecular self-assembly and nanotechnology are integrated [24]. Compared to traditional drug carriers, SADDS can deliver themselves in vivo with the unique advantages of high drug loads, no drug leakage, and controlled drug release at the targets.…”

Untitled

“…Depending upon the chemical structure of the drug-lipid complex they may exist as ultrafine vesicular, micellar, or hexagonal aggregates. As the system is formed by linking a drug (pharmakon) to a carrier (soma), they are termed as "pharmacosomes" 11 . They are an effective tool to achieve desired therapeutic goals such as drug targeting and controlled release.…”