Self-assembled Gallic acid loaded lecithin-chitosan hybrid nanostructured gel as a potential tool against imiquimod-induced psoriasis

Hazari, Sahim Aziz; Sheikh, Afsana; Abourehab, Mohammed A.S.; Tulbah, Alaa S.; Kesharwani, Prashant

doi:10.1016/j.envres.2023.116562

Cited by 5 publications

(2 citation statements)

References 57 publications

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“… [ 131 ] 14 Hybrid nanoparticles Lecithin, low molecular weight chitosan, acetic acid, tween 170.5 ± 0.087 nm Ionic-gelation method Gallic Acid BALB/c mice It demonstrates improved penetration, substantial retention, fewer side effects, and heightened efficacy against IMQ-induced psoriasis. [ 132 ] Cholecalciferol, methoxy poly, DL-lactide, stannous octanoate, tween 80, carbopol 974P 123.1 nm Hot homogenization method Vitamin D3 Swiss albino mice It enhances the anti-psoriatic activity of vitamin D3, resulting in an improved Psoriasis Area and Severity Index (PASI) score. [ 133 ] Carbopol 974P, cholesterol, cholic acid, DL-lactide, stannous 2-ethyl hexanoate 94.8 nm - Clobetasol propionate Swiss albino mice It exhibits improved cellular uptake, heightened skin penetration, and enhanced skin retention.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, it mitigates irritation, reduces PASI scores, and addresses splenomegaly. 132 Pukale, S.S., A. Mittal, and D. Chitkara formulated monolithic lipid-polymer hybrid nanoparticles (VD3/LPHNPs) loaded with vitamin D3 and developed them into a topical gel containing VD3/LPHNPs. This formulation exhibited marked improvement in histopathology and PASI scores in a psoriasis mouse model, surpassing the antipsoriasis activity of free VD3 gel.…”

Section: Discussionmentioning

confidence: 99%

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Recent Advancements and Trends of Topical Drug Delivery Systems in Psoriasis: A Review and Bibliometric Analysis

An,

Zhao,

Hao

et al. 2024

IJN

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Psoriasis is an immune-mediated inflammatory skin disease where topical therapy is crucial. While various dosage forms have enhanced the efficacy of current treatments, their limited permeability and lack of targeted delivery to the dermis and epidermis remain challenges. We reviewed the evolution of topical therapies for psoriasis and conducted a bibliometric analysis from 1993 to 2023 using a predictive linear regression model. This included a comprehensive statistical and visual evaluation of each model’s validity, literature profiles, citation patterns, and collaborations, assessing R variance and mean squared error (MSE). Furthermore, we detailed the structural features and penetration pathways of emerging drug delivery systems for topical treatment, such as lipid-based, polymer-based, metallic nanocarriers, and nanocrystals, highlighting their advantages. This systematic overview indicates that future research should focus on developing novel drug delivery systems characterized by enhanced stability, biocompatibility, and drug-carrying capacity.

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