Self-assembled gold nano islands for precise electrochemical sensing of trace level of arsenic in water

Fuletra, Isha; Chansi,; Nisar, Sumaya; Bhardwaj, Rashi; Saluja, Punya; Bhardwaj, Sheetal K.; Asokan, K.; Basu, Tinku

doi:10.1016/j.gsd.2020.100528

Cited by 13 publications

(5 citation statements)

References 43 publications

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“…These kinds of sensors are highly effective tools to recognise the target analyte, with significant sensitivity and selectivity [1,2,25,26]. However, a major challenge is related to the successful immobilization of biomolecules (enzyme/antibodies/DNA) on the surface of the applied transducer [25][26][27][28][29][30]. For this purpose, it is fundamental to modify the surface of the working electrode to enhance the connection with the antibody receptor.…”

Section: Introductionmentioning

confidence: 99%

Impedimetric and Plasmonic Sensing of Collagen I Using a Half-Antibody-Supported, Au-Modified, Self-Assembled Monolayer System

et al. 2021

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This research presents an electrochemical immunosensor for collagen I detection using a self-assembled monolayer (SAM) of gold nanoparticles (AuNPs) and covalently immobilized half-reduced monoclonal antibody as a receptor; this allowed for the validation of the collagen I concentration through two different independent methods: electrochemically by Electrochemical Impedance Spectroscopy (EIS), and optically by Surface Plasmon Resonance (SPR). The high unique advantage of the proposed sensor is based on the performance of the stable covalent immobilization of the AuNPs and enzymatically reduced half-IgG collagen I antibodies, which ensured their appropriate orientation onto the sensor’s surface, good stability, and sensitivity properties. The detection of collagen type I was performed in a concentration range from 1 to 5 pg/mL. Moreover, SPR was utilized to confirm the immobilization of the monoclonal half-antibodies and sensing of collagen I versus time. Furthermore, EIS experiments revealed a limit of detection (LOD) of 0.38 pg/mL. The selectivity of the performed immunosensor was confirmed by negligible responses for BSA. The performed approach of the immunosensor is a novel, innovative attempt that enables the detection of collagen I with very high sensitivity in the range of pg/mL, which is significantly lower than the commonly used enzyme-linked immunosorbent assay (ELISA).

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Section: Introductionmentioning

confidence: 99%

Impedimetric and Plasmonic Sensing of Collagen I Using a Half-Antibody-Supported, Au-Modified, Self-Assembled Monolayer System

et al. 2021

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“…As Lingervelder et al have reviewed, for general practitioners, the clinical utility of POC testing is the most critical aspect [ 65 ]. To ensure POCT’s usefulness to clinicians, future research [ 74 ], despite focusing on the analytical and technical performances of a test, should also tackle the aspects relating to the clinical utility and risks [ 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 ]. Moreover, in the case of smartphone-connected POCT devices, the issues related to data sensitivity, including privacy and protection against theft and medical advice, should be addressed [ 69 ].…”

Section: Challenges and Perspectives Towards Poc Diagnostics Of Damentioning

confidence: 99%

“…Biosensors 2021, 11, x FOR PEER REVIEW 10 of 14 risks[75][76][77][78][79][80][81][82][83]. Moreover, in the case of smartphone-connected POCT devices, the issues related to data sensitivity, including privacy and protection against theft and medical advice, should be addressed[69].…”

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confidence: 99%

Using Graphene-Based Biosensors to Detect Dopamine for Efficient Parkinson’s Disease Diagnostics

2021

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Parkinson’s disease (PD) is a neurodegenerative disease in which the neurotransmitter dopamine (DA) depletes due to the progressive loss of nigrostriatal neurons. Therefore, DA measurement might be a useful diagnostic tool for targeting the early stages of PD, as well as helping to optimize DA replacement therapy. Moreover, DA sensing appears to be a useful analytical tool in complex biological systems in PD studies. To support the feasibility of this concept, this mini-review explores the currently developed graphene-based biosensors dedicated to DA detection. We discuss various graphene modifications designed for high-performance DA sensing electrodes alongside their analytical performances and interference studies, which we listed based on their limit of detection in biological samples. Moreover, graphene-based biosensors for optical DA detection are also presented herein. Regarding clinical relevance, we explored the development trends of graphene-based electrochemical sensing of DA as they relate to point-of-care testing suitable for the site-of-location diagnostics needed for personalized PD management. In this field, the biosensors are developed into smartphone-connected systems for intelligent disease management. However, we highlighted that the focus should be on the clinical utility rather than analytical and technical performance.

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“…The detailed study for quality aspects of biomassderived graphene will give a clear vision towards specific applications. As the outcomes of the conducted research are fascinating to gain the attention of scientists globally, and we believe that bio-inspired graphene will be one of the welltaken and well-accepted future material science and can be a backbone of future biomedical research, [185][186][187][188][189][190][191][192] as proposed in figure 9.…”

Section: Challenges and Viewpointmentioning

confidence: 99%

Bio-inspired graphene-based nano-systems for biomedical applications

Bhardwaj¹,

Mujawar

Mishra

et al. 2021

Nanotechnology

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The increasing demands of environmentally sustainable, affordable, and scalable materials have inspired researchers to explore greener nanosystems of unique properties which can enhance the performance of existing systems. Such nanosystems, extracted from nature, are state-of-art highperformance nanostructures due to intrinsic hierarchical micro/nanoscale architecture and generous interfacial interactions in natural resources. Among several, bio-inspired nanosystems graphene nanosystems have emerged as an essential nano-platform wherein a highly electroactive, scalable, functional, flexible, and adaptable to a living being is a key factor. Preliminary investigation project bio-inspired graphene nanosystems as a multi-functional nanoplatform suitable for electronic devices, energy storage, sensors, and medical sciences application. However, a broad understanding of bio-inspired graphene nanosystems and their projection towards applied application is not well-explored yet. Considering this as a motivation, this mini-review highlights the following; the emergence of bio-inspired graphene nanosystems, over time development to make them more efficient, state-of-art technology, and potential applications, mainly biomedical including biosensors, drug delivery, imaging, and biomedical systems. The outcomes of this review will certainly serve as a guideline to motivate scholars to design and develop novel bio-inspired graphene nanosystems to develop greener, affordable, and scalable next-generation biomedical systems.

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Self-assembled gold nano islands for precise electrochemical sensing of trace level of arsenic in water

Cited by 13 publications

References 43 publications

Impedimetric and Plasmonic Sensing of Collagen I Using a Half-Antibody-Supported, Au-Modified, Self-Assembled Monolayer System

Impedimetric and Plasmonic Sensing of Collagen I Using a Half-Antibody-Supported, Au-Modified, Self-Assembled Monolayer System

Using Graphene-Based Biosensors to Detect Dopamine for Efficient Parkinson’s Disease Diagnostics

Bio-inspired graphene-based nano-systems for biomedical applications

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