Self-assembled gold nanoparticles for<i>in-vitro</i>inhibition of bovine viral diarrhea virus as surrogate model for HCV

El-Gaffary, M.; Bashandy, M. M.; Ahmed, Aquil; El-Borady, Ola M.

doi:10.1088/2053-1591/ab18b6

Cited by 10 publications

(9 citation statements)

References 37 publications

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“…Thiol-capped AuNPs also displayed powerful inactivation of bovine viral diarrhea virus in vitro . 43 Multivalency has been exploited in more complex systems using dendrons as capping agents. This strategy allows to generate higher concentrations of the target ligand in close proximity to the AuNPs and to increase the binding efficiency of the nanoparticles to the capsid.…”

Section: Blocking Viral Entrymentioning

confidence: 99%

Hard Nanomaterials in Time of Viral Pandemics

et al. 2020

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The SARS-Cov-2 pandemic has spread worldwide during 2020, setting up an uncertain start of this decade. The measures to contain infection taken by many governments have been extremely severe by imposing home lockdown and industrial production shutdown, making this the biggest crisis since the second world war. Additionally, the continuous colonization of wild natural lands may touch unknown virus reservoirs, causing the spread of epidemics. Apart from SARS-Cov-2, the recent history has seen the spread of several viral pandemics such as H2N2 and H3N3 flu, HIV, and SARS, while MERS and Ebola viruses are considered still in a prepandemic phase. Hard nanomaterials (HNMs) have been recently used as antimicrobial agents, potentially being next-generation drugs to fight viral infections. HNMs can block infection at early (disinfection, entrance inhibition) and middle (inside the host cells) stages and are also able to mitigate the immune response. This review is focused on the application of HNMs as antiviral agents. In particular, mechanisms of actions, biological outputs, and limitations for each HNM will be systematically presented and analyzed from a material chemistry point-of-view. The antiviral activity will be discussed in the context of the different pandemic viruses. We acknowledge that HNM antiviral research is still at its early stage, however, we believe that this field will rapidly blossom in the next period.

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Section: Blocking Viral Entrymentioning

confidence: 99%

Hard Nanomaterials in Time of Viral Pandemics

et al. 2020

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“…The possible toxic effects of the nine formulations of ACA-NFs on MBDK cells were assessed via the MTT cell viability assay (the gold standard for cytotoxicity 65 ) as well as microscopic examination. 66 The antiviral activity of the ACA-NFs was evaluated based on the ability of ACA to prevent the cytopathic effects (CPE) of the virus on MBDK cell culture and the results were recorded ( Table S2 ). The antiviral activity dramatically increased in a dose-dependent manner up to 78.14%, 87.16%, and 98.88% with concentrations 1, 3 and 6 ppm of ACA-NFs with a minor cytotoxicity of 6.30 ± 4.31%, 5.00 ± 0.023% and 8.3 ± 0.16% (P<0.05), respectively ( Figure 8 ).…”

Section: Resultsmentioning

confidence: 99%

New Acaciin-Loaded Self-Assembled Nanofibers as MPro Inhibitors Against BCV as a Surrogate Model for SARS-CoV-2

Mohamad¹,

Zahran²,

Fadeel³

et al. 2021

IJN

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“…Compared to silver nanoparticles, AuNPs display better results in in vivo studies. AuNPs can interact with the haemagglutinin (HA) glycoprotein and can oxidize the disulfide bond, resulting in the inactivation of the virus [158]. Surface properties are useful in targeting the virus.…”

Section: Nano-phytopharmaceuticals In Pulmonary Disordersmentioning

confidence: 99%

Precision and Advanced Nano-Phytopharmaceuticals for Therapeutic Applications

et al. 2022

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Phytopharmaceuticals have been widely used globally since ancient times and acknowledged by healthcare professionals and patients for their superior therapeutic value and fewer side-effects compared to modern medicines. However, phytopharmaceuticals need a scientific and methodical approach to deliver their components and thereby improve patient compliance and treatment adherence. Dose reduction, improved bioavailability, receptor selective binding, and targeted delivery of phytopharmaceuticals can be likely achieved by molding them into specific nano-formulations. In recent decades, nanotechnology-based phytopharmaceuticals have emerged as potential therapeutic candidates for the treatment of various communicable and non-communicable diseases. Nanotechnology combined with phytopharmaceuticals broadens the therapeutic perspective and overcomes problems associated with plant medicine. The current review highlights the therapeutic application of various nano-phytopharmaceuticals in neurological, cardiovascular, pulmonary, and gastro-intestinal disorders. We conclude that nano-phytopharmaceuticals emerge as promising therapeutics for many pathological conditions with good compliance and higher acceptance.

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Self-assembled gold nanoparticles forin-vitroinhibition of bovine viral diarrhea virus as surrogate model for HCV

Cited by 10 publications

References 37 publications

Hard Nanomaterials in Time of Viral Pandemics

Hard Nanomaterials in Time of Viral Pandemics

New Acaciin-Loaded Self-Assembled Nanofibers as MPro Inhibitors Against BCV as a Surrogate Model for SARS-CoV-2

Precision and Advanced Nano-Phytopharmaceuticals for Therapeutic Applications

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