2014
DOI: 10.1038/srep04466
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Self-assembled hydrogel fibers for sensing the multi-compartment intracellular milieu

Abstract: Targeted delivery of drugs and sensors into cells is an attractive technology with both medical and scientific applications. Existing delivery vehicles are generally limited by the complexity of their design, dependence on active transport, and inability to function within cellular compartments. Here, we developed self-assembled nanofibrous hydrogel fibers using a biologically inert, low-molecular-weight amphiphile. Self-assembled nanofibrous hydrogels offer unique physical/mechanical properties and can easily… Show more

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Cited by 18 publications
(20 citation statements)
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“…He has published 4220 refereed research papers. Such gels are attractive candidates for a diverse range of applications in a number of diverse fields, including the design and synthesis of biomaterials, [16][17][18][19][20][21] nano-materials, [22][23][24][25][26][27][28][29][30][31] stimuliresponsive materials, 32 sensors, [33][34][35][36] and templating components for inorganic or organic nanostructures, 37 as well as in molecular electronics [38][39][40][41] and catalysis. Extensive research efforts towards the evolution of novel properties utilizing the underlying principles of self-assembly (i.e., hydrogen bonding, p-p stacking, solvophobic effects, van der Waals forces, charge-transfer interactions and metal-ligand coordination) as a key route has led to the generation of a vast area of research known as supramolecular chemistry.…”
Section: Santanu Bhattacharyamentioning
confidence: 99%
“…He has published 4220 refereed research papers. Such gels are attractive candidates for a diverse range of applications in a number of diverse fields, including the design and synthesis of biomaterials, [16][17][18][19][20][21] nano-materials, [22][23][24][25][26][27][28][29][30][31] stimuliresponsive materials, 32 sensors, [33][34][35][36] and templating components for inorganic or organic nanostructures, 37 as well as in molecular electronics [38][39][40][41] and catalysis. Extensive research efforts towards the evolution of novel properties utilizing the underlying principles of self-assembly (i.e., hydrogen bonding, p-p stacking, solvophobic effects, van der Waals forces, charge-transfer interactions and metal-ligand coordination) as a key route has led to the generation of a vast area of research known as supramolecular chemistry.…”
Section: Santanu Bhattacharyamentioning
confidence: 99%
“…Although endosomal pH has attracted substantial interest, it is of course also possible to use nanoparticles to probe the pH in other parts of a cell. For example, Vemula et al encapsulated pHrodo TM dye with self-assembled hydrogel nanofibers [69] and used these to determine the pH in the cytoplasm, phagosomes and nucleus.…”
Section: Measurement and Mapping Of Phmentioning
confidence: 99%
“…The incorporation of the thermoresponsive hydrophobic colloidal network slightly reduces the high mechanical strength that is observed in pure DN hydrogels without nanoemulsions. The advantage of our system is that the morphological microstructure can be tuned via temperature, surfactant concentration, and dispersed phase volume fraction, thus providing an ideal chemical and mechanical environment for the coexistence of hydrophobic/hydrophilic materials for applications such as controlled release, actuators for fluidics, synthetic vasculature, as well as the synthesis microstructured fibers for controlled drug delivery …”
Section: Introductionmentioning
confidence: 99%