Self-assembled iRGD-R7-LAHP-M nanoparticle induced sufficient singlet oxygen and enhanced tumor penetration immunological therapy

Wang, Yu-e; Zhai, Junqiu; Zheng, Yuxiu; Pan, Jiali; Liu, Xiaojia; Ma, Yan; Guan, Shixia

doi:10.1039/d2nr02809c

Cited by 9 publications

(2 citation statements)

References 65 publications

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“…For ferulic acid, metal coordination complexes with Co 2+ , Ni 2+ , Cu 2+ , Zn 2+ , Mn 2+ , Mg 2+ , Fe 2+ , Fe 3+ and Na + are found [161][162][163][164][165][166][167][168][169][170]. For linoleic acid, metal complexes with Fe 2+ , Fe 3+ , Cu 2+ and Pt 2+ are described [171][172][173]. In general, metal complexes again show better antioxidant/antiinflammatory behavior than the free ligands.…”

Section: Discussing Unexpected Dose-response Curves In Natural Bioact...mentioning

confidence: 92%

Enemies or Allies? Hormetic and Apparent Non-Dose-Dependent Effects of Natural Bioactive Antioxidants in the Treatment of Inflammation

Barreiro-Sisto,

Fernández-Fariña,

González-Noya

et al. 2024

IJMS

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This review aims to analyze the emerging number of studies on biological media that describe the unexpected effects of different natural bioactive antioxidants. Hormetic effects, with a biphasic response depending on the dose, or activities that are apparently non-dose-dependent, have been described for compounds such as resveratrol, curcumin, ferulic acid or linoleic acid, among others. The analysis of the reported studies confirms the incidence of these types of effects, which should be taken into account by researchers, discarding initial interpretations of imprecise methodologies or measurements. The incidence of these types of effects should enhance research into the different mechanisms of action, particularly those studied in the field of basic research, that will help us understand the causes of these unusual behaviors, depending on the dose, such as the inactivation of the signaling pathways of the immune defense system. Antioxidative and anti-inflammatory activities in biological media should be addressed in ways that go beyond a mere statistical approach. In this work, some of the research pathways that may explain the understanding of these activities are revised, paying special attention to the ability of the selected bioactive compounds (curcumin, resveratrol, ferulic acid and linoleic acid) to form metal complexes and the activity of these complexes in biological media.

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Section: Discussing Unexpected Dose-response Curves In Natural Bioact...mentioning

confidence: 92%

Enemies or Allies? Hormetic and Apparent Non-Dose-Dependent Effects of Natural Bioactive Antioxidants in the Treatment of Inflammation

Barreiro-Sisto,

Fernández-Fariña,

González-Noya

et al. 2024

IJMS

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“…As one special treatment, photodynamic therapy (PDT) has drawn more attention due to its noninvasive property, high spatiotemporal performance, and weak side effect, which is distinguished from traditional treatment modalities such as chemotherapy and radiotherapy. − Generally, the photosensitizers (PSs) could convert oxygen into cytotoxic singlet oxygen ( 1 O 2 ) for cancer cell apoptosis after specific light irradiation. However, since the excited light is hard to reach deep metastasis sites due to the limited penetration, their clinical application was confined on superficial tumors or lesions such as oral cancer, skin cancer, and esophageal cancer. − Thus, the PDT efficacy and its application were seriously restricted by the wavelength of the light.…”

Section: Introductionmentioning

confidence: 99%

Host–Guest Interaction-Based Supramolecular Self-Assemblies for H₂O₂ Upregulation Augmented Chemiluminescence Resonance Energy Transfer-Induced Cancer Therapy

Liu

Duan

et al. 2023

ACS Appl. Mater. Interfaces

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Given that light is hard to reach deep tumor tissue, how to enhance photodynamic therapy (PDT) efficacy is a big challenge. Herein, we proposed the supramolecular polymer self-assemblies (HACP) with bis[2,4,5-trichloro-6 (pentyloxycar-bonyl) phenyl] oxalate as the cargos (HACP@CPPO) to realize the chemiluminescence resonance energy transfer (CRET)-induced generation of 1O2 in situ. HACP was prepared by cinnamaldehyde-modified hyaluronic acid (HA-CA) and β-cyclodextrin-modified protoporphyrin IX (β-CD-PPIX) via host–guest interactions. The CA moiety could elevate H2O2 levels for the enhanced production of chemical energy and macrocyclic CD could enhance the stacking distance of PPIX for enhanced 1O2 yield. Thus, HACP@CPPO exhibited excellent antitumor performance without light irradiation.

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Tumor‐Targeted Catalytic Immunotherapy

Yang,

Wang,

Liu

et al. 2024

Advanced Materials

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Cancer immunotherapy holds significant promise for improving cancer treatment efficacy; however, the low response rate remains a considerable challenge. To overcome this limitation, advanced catalytic materials offer potential in augmenting catalytic immunotherapy by modulating the immunosuppressive tumor microenvironment (TME) through precise biochemical reactions. Achieving optimal targeting precision and therapeutic efficacy necessitates a thorough understanding of the properties and underlying mechanisms of tumor‐targeted catalytic materials. This review provides a comprehensive and systematic overview of recent advancements in tumor‐targeted catalytic materials and their critical role in enhancing catalytic immunotherapy. It highlights the types of catalytic reactions, the construction strategies of catalytic materials, and their fundamental mechanisms for tumor targeting, including passive, bioactive, stimuli‐responsive, and biomimetic targeting approaches. Furthermore, this review outlines various tumor‐specific targeting strategies, encompassing tumor tissue, tumor cell, exogenous stimuli‐responsive, TME‐responsive, and cellular TME targeting strategies. Finally, the discussion addresses the challenges and future perspectives for transitioning catalytic materials into clinical applications, offering insights that pave the way for next‐generation cancer therapies and provide substantial benefits to patients in clinical settings.

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Self-assembled iRGD-R7-LAHP-M nanoparticle induced sufficient singlet oxygen and enhanced tumor penetration immunological therapy

Abstract: The generation of singlet oxygen (1O2) from photodynamic therapy (PDT) is limited by the hypoxia of the tumor microenvironment and the depth of external light penetration because it depends on...

Cited by 9 publications

References 65 publications

Enemies or Allies? Hormetic and Apparent Non-Dose-Dependent Effects of Natural Bioactive Antioxidants in the Treatment of Inflammation

Enemies or Allies? Hormetic and Apparent Non-Dose-Dependent Effects of Natural Bioactive Antioxidants in the Treatment of Inflammation

Host–Guest Interaction-Based Supramolecular Self-Assemblies for H₂O₂ Upregulation Augmented Chemiluminescence Resonance Energy Transfer-Induced Cancer Therapy

Tumor‐Targeted Catalytic Immunotherapy

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Self-assembled iRGD-R7-LAHP-M nanoparticle induced sufficient singlet oxygen and enhanced tumor penetration immunological therapy

Abstract: The generation of singlet oxygen (1O2) from photodynamic therapy (PDT) is limited by the hypoxia of the tumor microenvironment and the depth of external light penetration because it depends on...

Cited by 9 publications

References 65 publications

Enemies or Allies? Hormetic and Apparent Non-Dose-Dependent Effects of Natural Bioactive Antioxidants in the Treatment of Inflammation

Enemies or Allies? Hormetic and Apparent Non-Dose-Dependent Effects of Natural Bioactive Antioxidants in the Treatment of Inflammation

Host–Guest Interaction-Based Supramolecular Self-Assemblies for H2O2 Upregulation Augmented Chemiluminescence Resonance Energy Transfer-Induced Cancer Therapy

Tumor‐Targeted Catalytic Immunotherapy

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Product

Resources

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Host–Guest Interaction-Based Supramolecular Self-Assemblies for H₂O₂ Upregulation Augmented Chemiluminescence Resonance Energy Transfer-Induced Cancer Therapy