Self-Assembled Maslinic Acid Attenuates Doxorobucin Induced Cytotoxicity via Nrf2 Signaling Pathway: An In Vitro and In Silico Study in Human Healthy Cells

Banerjee, Jhimli; Hasan, Sk Nurul; Samanta, Sovan; Giri, Biplab; Bag, Braja Gopal; Dash, Sandeep Kumar

doi:10.1007/s12013-022-01083-3

Cited by 8 publications

(3 citation statements)

References 61 publications

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“…Previous studies have already confirmed that MA has antioxidative effects in several other cell types, including human umbilical vein endothelial cells [ 27 ], vascular smooth muscle cells [ 35 ], human healthy peripheral blood mononuclear cells [ 40 ] and pheochromocytoma cells [ 31 ]; however, the present study is the first to evaluate the effect of MA on the in vitro development of porcine PA and SCNT embryos during the early stage in IVC with prolonged ROS accumulation. Our data showed that supplementation with 1 µM MA markedly increased the development rate and quality of porcine early-stage embryos, as demonstrated by improved blastocyst formation, hatching and total cell numbers; promoted proliferation; reduced apoptosis; and increased ΔΨm and ATP levels.…”

Section: Discussionmentioning

confidence: 74%

Maslinic Acid Supplementation during the In Vitro Culture Period Ameliorates Early Embryonic Development of Porcine Embryos by Regulating Oxidative Stress

Yang

Sun

et al. 2023

Animals

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As a pentacyclic triterpene, MA exhibits effective free radical scavenging capabilities. The purpose of this study was to explore the effects of MA on porcine early-stage embryonic development, oxidation resistance and mitochondrial function. Our results showed that 1 μM was the optimal concentration of MA, which resulted in dramatically increased blastocyst formation rates and improvement of blastocyst quality of in vitro-derived embryos from parthenogenetic activation (PA) and somatic cell nuclear transfer (SCNT). Further analysis indicated that MA supplementation not only significantly decreased the abundance of intracellular reactive oxygen species (ROS) and dramatically increased the abundance of intracellular reductive glutathione (GSH) in porcine early-stage embryos, but also clearly attenuated mitochondrial dysfunction and inhibited apoptosis. Moreover, Western blotting showed that MA supplementation upregulated OCT4 (p < 0.01), SOD1 (p < 0.0001) and CAT (p < 0.05) protein expression in porcine early-stage embryos. Collectively, our data reveal that MA supplementation exerts helpful effects on porcine early embryo development competence via regulation of oxidative stress (OS) and amelioration of mitochondrial function and that MA may be useful for increasing the in vitro production (IVP) efficiency of porcine early-stage embryos.

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Section: Discussionmentioning

confidence: 74%

Maslinic Acid Supplementation during the In Vitro Culture Period Ameliorates Early Embryonic Development of Porcine Embryos by Regulating Oxidative Stress

Yang

Sun

et al. 2023

Animals

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“…A report of a terpenoid-based suprastructure, dating back to 2005 (Bag et al) reported the first isolation of a derivative of arjunolic acid-formed gel in an organic solvent. Since then, the studies on terpenoid self-assembly in organic solvents have been expanded to more than sixty molecules, including asiatic acid, 138 betulinic acid, 139 β-glycyrrhetinic acid, 140 oleanolic acid, 141 glycyrrhetinic acid, 142 betulin, 143 ursolic acid, 144 crotocembraneic acid, 145 α-onocerin, 146 corosolic acid, 147 maslinic acid, 148 erythrodiol, 149 androgra pholide, 150 lupeol, 151 uvaol, 152 and maslinic acid. 153 Tubules, strands, tapes, chiral ribbons, flowers, vesicles, and other aggregates with high aspect ratio are possible forms of the resulting suprastructures (Figure 4).…”

Section: Assembly At the Molecular Scalementioning

confidence: 99%

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confidence: 99%

Bark extractives as sources of carbon-efficient functional precursors and materials

Niu,

He,

Musl

et al. 2024

TIMS

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<p>Biomass residues generated in forest operations represent an abundant and renewable resource in need for valorization. Bark is becoming increasingly relevant, not only in the bioproducts sector, but also in the context of the circular bioeconomy, which is placing emphasis on underutilized residues and waste. Among these, tree bark is one of the largest forestry by-products, accessible at a megaton scale but so far mostly utilized for its solid fuel value. Bark valorization should include the isolation of valuable natural compounds that add functionalities to a variety of bioproducts. This is the subject of this review, which considers bark extractives prospects, under the biorefinery concept, placing attention on extractives' chemical profiles and properties. We introduce the most recent pathways reported for bark fractionation and the opportunities to achieve new materials by using the concepts of supramolecular chemistry, leading to special assemblies. We show that value-added chemicals and materials are possible and expected to become most relevant in efforts aimed at maximizing bark utilization.</p>

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Room temperature magnetic ordering and in vitro antibacterial potency of Nd3+ doped CeO2 against the pathogenic bacterial strains

Karmakar,

Samanta,

Chattopadhyay

et al. 2023

Chemical Physics Impact

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Self-Assembled Maslinic Acid Attenuates Doxorobucin Induced Cytotoxicity via Nrf2 Signaling Pathway: An In Vitro and In Silico Study in Human Healthy Cells

Cited by 8 publications

References 61 publications

Maslinic Acid Supplementation during the In Vitro Culture Period Ameliorates Early Embryonic Development of Porcine Embryos by Regulating Oxidative Stress

Maslinic Acid Supplementation during the In Vitro Culture Period Ameliorates Early Embryonic Development of Porcine Embryos by Regulating Oxidative Stress

Bark extractives as sources of carbon-efficient functional precursors and materials

Room temperature magnetic ordering and in vitro antibacterial potency of Nd3+ doped CeO2 against the pathogenic bacterial strains

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