Self-assembled micellar nanostructures of ursolic acid-polyethylene glycol (UA-PEG) conjugate as efficient drug transporter system

Deka, Smriti Rekha; Verma, Pratiksha; Singh, Reena; Kumar, Pradeep

doi:10.1016/j.nanoso.2021.100688

Cited by 9 publications

(9 citation statements)

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“…Cytotoxicity of HA, HD-2, HD-2(TG) and TG was determined by the standard MTT assay [47][48][49] on HepG2, HeLa and HEK293 cells. In a culture plate, cells were treated with HA, HD-2, HD-2(TG) and TG at various concentrations (i.e.…”

Section: Mtt Assaymentioning

confidence: 99%

“…In vitro cellular uptake studies Like MTT assay, here, HeLa cells were treated with fluorescein-HD-2 and fluorescein-HD-2(TG) samples at IC 50 values, i.e. 100.38 and 119.22 μg, 48,49 and incubated for various time points, i.e. 0.5, 1.5, 4 and 8 h. ImageJ software was used for determination of collected total cell fluorescence (CTCF) values.…”

Section: Preparation Of Fluorescein-labeled Hd Nanoparticlesmentioning

confidence: 99%

“…The encapsulation occurred due to hydrophobic-hydrophobic interactions and an increase in the size of the drug-loaded structures might be owing to the size of the drug molecules. 49 Physical studies of the drug-loaded nanoparticles were carried out by recording absorption spectra in water. UV-visible spectrum of HD-2(TG) was recorded and the appearance of a new absorption band at 345 nm, which was absent in the spectrum of HD-2, confirmed the successful incorporation of TG into the nanoparticles.…”

Section: Drug Loading and Entrapment Efficiencymentioning

confidence: 99%

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Design, fabrication and evaluation of amphiphilic hyaluronic acid conjugates as efficient carriers of 6‐thioguanine for in vitro anticancer drug delivery applications

Deka

Singh

Verma

et al. 2022

Polymer International

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Nanoparticle‐based polymeric carriers are highly desirable for efficient delivery of hydrophobic drugs. The development of nanocarriers with high encapsulation efficiency synthesized by a simple emulsification technique has become a challenging task with their controlled and sustained release ability at disease sites. Here, we have synthesized a series of hydrophobically modified hyaluronic–dodecylamide (HD) conjugates by coupling dodecylamine onto hyaluronic acid in varying amounts and characterized them using physicochemical techniques. The synthesized HD conjugates, in an aqueous medium, self‐assembled into nanoparticles of size in the range of ca 189–355 nm with hydrophilic surface and hydrophobic core. 6‐Thioguanine (TG) was used as a model drug for encapsulation into the hydrophobic core of the conjugate (HD‐2) by the standard emulsification technique with high encapsulation efficiency. Spectrophotometric analysis revealed that the drug‐loaded nanoconjugate showed a sustained release of drug over a period of time and also showed enzymatic responsiveness towards hyaluronidase. In vitro experiments were performed with HEK293, HeLa and HepG2 cells and it was observed that drug‐loaded nanoparticles were more toxic towards cancerous cells as compared with free TG. These results advocate that the reported system, being biocompatible, could be used as promising anticancer drug delivery system. © 2022 Society of Industrial Chemistry.

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Section: Mtt Assaymentioning

confidence: 99%

Section: Preparation Of Fluorescein-labeled Hd Nanoparticlesmentioning

confidence: 99%

Section: Drug Loading and Entrapment Efficiencymentioning

confidence: 99%

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Design, fabrication and evaluation of amphiphilic hyaluronic acid conjugates as efficient carriers of 6‐thioguanine for in vitro anticancer drug delivery applications

Deka

Singh

Verma

et al. 2022

Polymer International

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“…The encapsulation of the drug in the core of a nanoarchitecture has played a pivotal role in enhancing its solubility in aqueous medium and duration of circulation in the body, thus enhancing the overall efficacy. Furthermore, the possibility of attaching the molecules having affinity towards select cells plays key role in targeted delivery of drugs directly to the site of interest 5,6 …”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, due to their high performance as wetting, cleaning, foaming, and emulsifying agents, these surface active molecules are used for stabilizing various colloidal systems including vesicles and emulsions, and also improve the solubility of poorly water soluble materials. 20,21 Considering the fact that shorter-chain PFAS are regarded as less toxic, less bio-accumulative, more mobile and persistent in aquatic ecosystems, 22,23 we have used an octanol (3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctanl-1-ol) having six fluorinated carbons for the synthesis of amphiphilic system for drug delivery applications. Watterson et al have previously reported the synthesis of the pluronic and perfluorinated chain based polymeric amphiphiles consisting of isophthalate central core via a chemoenzymatic approach.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and transport potential study of A₂B type double chain amphiphilic architectures

Aarti,

Krishna,

Syeda

et al. 2023

Polymers for Advanced Techs

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The inefficient delivery of drugs having low efficacy to their target sites is significantly hampering the treatment of many diseases and putting enormous pressure on the healthcare system. In this endeavor, the non‐ionic amphiphilic nanotransporters are drawing increasing attention over the past decades. Herein, we report the synthesis of a newer A2B type non‐ionic double chain amphiphilic nanotransporters by using dimethyl 5‐hydroxy isophthalate based central core prepared by propargylation followed by ester hydrolysis. The core was subsequently decorated with hydrophobic alkyl (C8/C20/perfluoro alkylated Cf8) chains via esterification. Monomethoxy polyethylene glycol (mPEG) moiety (Mn: 750/1000) was then incorporated by click chemistry approach to confer hydrophilicity. The aggregation behavior of synthesized non‐ionic amphiphiles in aqueous medium was evaluated by using dynamic light scattering (DLS) and fluorescence spectroscopy. The nanotransport potential of the synthesized amphiphiles was studied by using model hydrophobic guests, that is, the dye Nile red and the drugs nimodipine and curcumin by using ultraviolet–visible (UV/Vis) and fluorescence spectroscopic techniques. Evaluation of the viability of amphiphiles synthesized against HeLa cells showed them to be well tolerated up to the concentration studied. Stimuli responsive release of encapsulated Nile red from the inner core of amphiphile was successfully carried out in the presence of an immobilized enzyme Candida antarctica lipase (Novozym 435). In nutshell, the results obtained from this study may be instrumental in the design and development of promising nanotransporters for biomedical applications.

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Self-assembled PEGylated micelles for precise and targeted drug delivery: Current challenges and future directions

Sinha,

Tripathi,

Pandey

et al. 2024

Biocatalysis and Agricultural Biotechnology

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Self-assembled micellar nanostructures of ursolic acid-polyethylene glycol (UA-PEG) conjugate as efficient drug transporter system

Cited by 9 publications

References 50 publications

Design, fabrication and evaluation of amphiphilic hyaluronic acid conjugates as efficient carriers of 6‐thioguanine for in vitro anticancer drug delivery applications

Design, fabrication and evaluation of amphiphilic hyaluronic acid conjugates as efficient carriers of 6‐thioguanine for in vitro anticancer drug delivery applications

Synthesis and transport potential study of A₂B type double chain amphiphilic architectures

Self-assembled PEGylated micelles for precise and targeted drug delivery: Current challenges and future directions

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Self-assembled micellar nanostructures of ursolic acid-polyethylene glycol (UA-PEG) conjugate as efficient drug transporter system

Cited by 9 publications

References 50 publications

Design, fabrication and evaluation of amphiphilic hyaluronic acid conjugates as efficient carriers of 6‐thioguanine for in vitro anticancer drug delivery applications

Design, fabrication and evaluation of amphiphilic hyaluronic acid conjugates as efficient carriers of 6‐thioguanine for in vitro anticancer drug delivery applications

Synthesis and transport potential study of A2B type double chain amphiphilic architectures

Self-assembled PEGylated micelles for precise and targeted drug delivery: Current challenges and future directions

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Synthesis and transport potential study of A₂B type double chain amphiphilic architectures