2023
DOI: 10.1002/adma.202309789
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Self‐Assembled Nano‐CT Contrast Agent Leveraging Size Aggregation for Improved In Vivo Tumor CT Imaging

Chengcheng Wang,
Jingjing Zhu,
Shasha Wang
et al.

Abstract: Computed tomography (CT) is a widely utilized noninvasive diagnostic tool in clinical practice. However, the commonly employed small molecular iodinated contrast agents (ICAs) in clinical CT imaging have limitations such as nonspecific distribution in body, rapid clearance through kidneys, etc., leading to a narrow imaging time window. In contrast, existing nano‐sized ICAs face challenges like structural uncertainty, poor reproducibility, low iodine content, and uniformity issues. In this study, we present a n… Show more

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Cited by 6 publications
(1 citation statement)
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“…Cancer remains a significant global health challenge, with traditional chemotherapy and radiotherapy showing limitations in terms of safety and efficacy, often accompanied by severe side effects [1][2][3]. Researchers have explored non-invasive approaches such as near-infrared (NIR) and ultrasound (US) for cancer treatment in pursuit of novel therapeutic modalities [4][5][6].…”
Section: Introductionmentioning
confidence: 99%
“…Cancer remains a significant global health challenge, with traditional chemotherapy and radiotherapy showing limitations in terms of safety and efficacy, often accompanied by severe side effects [1][2][3]. Researchers have explored non-invasive approaches such as near-infrared (NIR) and ultrasound (US) for cancer treatment in pursuit of novel therapeutic modalities [4][5][6].…”
Section: Introductionmentioning
confidence: 99%