Self-Assembled Nanomaterials for Chronic Skin Wound Healing

Kang, Hwan June; Chen, Nuozhou; Dash, Biraja C.; Hsia, Henry C.; Berthiaume, François

doi:10.1089/wound.2019.1077

Cited by 25 publications

(22 citation statements)

References 49 publications

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“…Self-assembly of amphiphilic polymers into 3D NF scaffolds is based on close mimicking of biological processes and functions of fibrous structures, and can be used for therapeutic purposes [ 18 , 19 ]. For example, some polypeptides can assemble via non-covalent and covalent interactions into fiber-like cylindric micelles and higher order structures such as ribbons and sheets.…”

Section: Methods Of Preparationmentioning

confidence: 99%

Nanofiber Carriers of Therapeutic Load: Current Trends

Jarak

Silva

Domingues

et al. 2022

IJMS

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The fast advancement in nanotechnology has prompted the improvement of numerous methods for the creation of various nanoscale composites of which nanofibers have gotten extensive consideration. Nanofibers are polymeric/composite fibers which have a nanoscale diameter. They vary in porous structure and have an extensive area. Material choice is of crucial importance for the assembly of nanofibers and their function as efficient drug and biomedicine carriers. A broad scope of active pharmaceutical ingredients can be incorporated within the nanofibers or bound to their surface. The ability to deliver small molecular drugs such as antibiotics or anticancer medications, proteins, peptides, cells, DNA and RNAs has led to the biomedical application in disease therapy and tissue engineering. Although nanofibers have shown incredible potential for drug and biomedicine applications, there are still difficulties which should be resolved before they can be utilized in clinical practice. This review intends to give an outline of the recent advances in nanofibers, contemplating the preparation methods, the therapeutic loading and release and the various therapeutic applications.

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Section: Methods Of Preparationmentioning

confidence: 99%

Nanofiber Carriers of Therapeutic Load: Current Trends

Jarak

Silva

Domingues

et al. 2022

IJMS

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“…It has good solubility in most pH solutions, including the oral cavity with pH = 6.8, and is a degradable polymer with good water solubility [ 107 ]. It has been shown that poly(aspartic acid) is a polymer that can replace acrylic acid and is greener and more economical [ 108 , 109 , 110 ]. Due to its versatility such as water solubility and biodegradability, PASP has great applications in water treatment, wound dressing, stent material, drug delivery and release, etc.…”

Section: Amino Acidmentioning

confidence: 99%

A Review on Electrospun Poly(amino acid) Nanofibers and Their Applications of Hemostasis and Wound Healing

Song

et al. 2022

Biomolecules

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The timely and effective control and repair of wound bleeding is a key research issue all over the world. From traditional compression hemostasis to a variety of new hemostatic methods, people have a more comprehensive understanding of the hemostatic mechanism and the structure and function of different types of wound dressings. Electrospun nanofibers stand out with nano size, high specific surface area, higher porosity, and a variety of complex structures. They are high-quality materials that can effectively promote wound hemostasis and wound healing because they can imitate the structural characteristics of the skin extracellular matrix (ECM) and support cell adhesion and angiogenesis. At the same time, combined with amino acid polymers with good biocompatibility not only has high compatibility with the human body but can also be combined with a variety of drugs to further improve the effect of wound hemostatic dressing. This paper summarizes the application of different amino acid electrospun wound dressings, analyzes the characteristics of different materials in preparation and application, and looks forward to the development of directions of poly(amino acid) electrospun dressings in hemostasis.

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“…Nanomaterials have attracted increasing attention from researchers and have been widely studied in tissue engineering and biomedicine due to their good biocompatibility, controllable preparation methods, and unique physical, chemical, and biological properties. [30][31][32] In the past few years, the research and development of nanomaterials and nanotechnology have provided many novel solutions and strategies for the treatment of acute or chronic skin wounds, which not only effectively overcome the defects of traditional treatments but also utilize the unique functions and properties of many nanomaterials. 33,34 Compared with traditional materials, nano materials can effectively enter the human body by changing the drug dosage form, improving the drug concentration in blood, controlling the drug release rate or delivering the drug to the wound site, and the special physical and chemical properties of nanomaterials show more advantages in the field of wound repair.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Nano-Formulations for Skin Wound Repair Applications

Lin¹,

Chen²,

Liu³

et al. 2022

DDDT

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Skin injuries caused by accidents and acute or chronic diseases place a heavy burden on patients and health care systems. Current treatments mainly depend on preventing infection, debridement, and hemostasis and on supplementing growth factors, but patients will still have scar tissue proliferation or difficulty healing and other problems after treatment. Conventional treatment usually focuses on a single factor or process of wound repair and often ignores the influence of the wound pathological microenvironment on the final healing effect. Therefore, it is of substantial research value to develop multifunctional therapeutic methods that can actively regulate the wound microenvironment and reduce the oxidative stress level at the wound site to promote the repair of skin wounds. In recent years, various bioactive nanomaterials have shown great potential in tissue repair and regeneration due to their properties, including their unique surface interface effect, small size effect, enzyme activity and quantum effect. This review summarizes the mechanisms underlying skin wound repair and the defects in traditional treatment methods. We focus on analyzing the advantages of different types of nanomaterials and comment on their toxicity and side effects when used for skin wound repair.

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Self-Assembled Nanomaterials for Chronic Skin Wound Healing

Cited by 25 publications

References 49 publications

Nanofiber Carriers of Therapeutic Load: Current Trends

Nanofiber Carriers of Therapeutic Load: Current Trends

A Review on Electrospun Poly(amino acid) Nanofibers and Their Applications of Hemostasis and Wound Healing

Recent Advances in Nano-Formulations for Skin Wound Repair Applications

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