Self-assembled nanoparticles of acetylated cashew gum: Characterization and evaluation as potential drug carrier

Pitombeira, Nadia A.O.; Neto, José Guilherme Veras; Silva, Durcilene Alves da; Feitosa, Judith P.A.; Paula, Haroldo C.B.; Paula, Regina C.M. de

doi:10.1016/j.carbpol.2014.09.087

Cited by 93 publications

(63 citation statements)

References 35 publications

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“…The polysaccharide from Cyclocarya paliurus was acetylated with acetic anhydride and the DS values changed from 0.13 to 0.54 with between one and six fold increases in the concentration of acetic anhydride [32]. Cashew gum was also acetylated with acetic anhydride and the DS value obtained was 2.8 [33].…”

Section: Characterisation Of Acetylated Sterculia Striata Polysaccharmentioning

confidence: 97%

Nanocapsules of Sterculia striata acetylated polysaccharide as a potential monomeric amphotericin B delivery matrix

Sombra¹,

Richter²,

Araújo

et al. 2019

International Journal of Biological Macromolecules

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Stable oil nanocapsules based on acetylated Sterculia striata polysaccharide (ASSP) were produced without the use of a surfactant, and derivatives of ASSP with four different degrees of substitution (DS) were synthesised. The data revealed that only derivatives with high DS were able to produce nanocapsules (NC), which exhibited monomodal size distribution profiles with a Z-average particle size,-potential, and polydispersity index (PDI) that were dependent on ASSP DS and concentration. Nanocapsules were loaded with amphotericin B (AMB) with encapsulation efficiencies (EE%) thatwere dependent on drug and ASSP concentrations and DS. A maximum EE% value of 99.2%was achieved, and the loaded AMBwas found to be in amonomeric form, evenwith a concentration one hundredfold higher than that usually observed for commercial AMB aqueous solutions. Loaded nanocapsules show an in vitro controlled release of AMB. As the monomeric AMB state decreased drug toxicity, ASSP nanocapsules loaded with AMB (NC1.68) have potential for use as a drug delivery system. AMB loaded NC 1.68 keeps its activity against 5 strains of Candida albicans tested.

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Section: Characterisation Of Acetylated Sterculia Striata Polysaccharmentioning

confidence: 97%

Nanocapsules of Sterculia striata acetylated polysaccharide as a potential monomeric amphotericin B delivery matrix

Sombra¹,

Richter²,

Araújo

et al. 2019

International Journal of Biological Macromolecules

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“…2.7-6.0 ppm. The protons attached to the C1s of the sugars occurred at the downfield region, together with the hydroxy groups (4.2-5.5 ppm) [50,51]. The peak at 1.1 ppm is due to the methyl in rhamnose, one of the sugars present in CG.…”

Section: Spectroscopic Characterizationmentioning

confidence: 99%

Hydrophobic Modification of Cashew Gum with Alkenyl Succinic Anhydride

et al. 2020

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Cashew gum (CG) shows promise of being useful as an agro-based raw material for the production of eco-friendly and biodegradable polymers. In this work, we modified this water-soluble polymer with alkenyl succinic anhydride in order to attach a hydrophobic group to it. The modification used two reagents: octenyl succinic anhydride and tetrapropenyl succinic anhydride. Reactions were conducted at 120 °C using dimethyl sulfoxide as a solvent, with conversions better than 88%. Samples with degrees of substitution (DS) between 0.02 and 0.20 were made. The resulting polymers were characterized using 1H NMR, 13C NMR, FTIR, TGA, and GPC. The addition of the hydrophobe decreased the affinity of cashew gum for water absorption. Hydrophobically modified polysaccharides are often used as polymeric emulsifiers, thickeners, and compatibilizers; we anticipate that these new hydrophobically modified CGs may be used for the same applications.

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“…The CG contains carboxyl groups, which corresponds to bands ranging around 2900 cm -1 (KOUPANTSIS et al, 2016;. Other studies have also mentioned a broadband in the region of 3390 cm -1 , being characteristic of the elongation of GE and CG O-H bonds (OLIVEIRA et al, 2014;PITOMBEIRA et al, 2015).…”

Section: Infrared Spectroscopic Analysismentioning

confidence: 94%

Cross-linked coacervates of cashew gum and gelatin in the encapsulation of pequi oil

et al. 2019

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Pequi oil is rich in bioactive compounds which can be encapsulated to increase protection against extrinsic environmental factors. A delayed degradation of pequi oil may occur by using microencapsulation technology, in addition to masking unpleasant flavors and aromas. Complex coacervation is a technique based on the electrostatic interaction between two oppositely charged biopolymers which form a matrix complexed around an agent of interest. However, cross-linking the particles is often necessary in order to make them more rigid. The objective of this research was to produce and characterize pequi oil microparticles in a cashew gum (CG) and gelatin (GE) matrix cross-linked with tannic acid. Cross-linked pequi oil microparticles were produced by varying the concentrations of biopolymers (0.5% to 1.5%) and tannic acid (0.3% to 8.1%) using a rotational central compound design. Ratio of cashew gum, gelatin and oil was 2:1:1 (m/m/m);respectively, at pH 4.5. The cross-linking process was performed with tannic acid for 30 minutes at 40 °C. The optimized formulation by means of the rotational central compound design for microparticle formation was 0.65% biopolymers (CG and GE) and 6.9% tannic acid. Increasing the tannic acid percentage in the cross-linking of the pequi oil particles had a higher yield and encapsulation efficiency. Cross-linking provided an increase in the degradation temperature of material; and consequently, improved the thermal stability of the particles. The cross-linking process was advantageous in producing the microparticles.

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Self-assembled nanoparticles of acetylated cashew gum: Characterization and evaluation as potential drug carrier

Cited by 93 publications

References 35 publications

Nanocapsules of Sterculia striata acetylated polysaccharide as a potential monomeric amphotericin B delivery matrix

Nanocapsules of Sterculia striata acetylated polysaccharide as a potential monomeric amphotericin B delivery matrix

Hydrophobic Modification of Cashew Gum with Alkenyl Succinic Anhydride

Cross-linked coacervates of cashew gum and gelatin in the encapsulation of pequi oil

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