Self-assembled nanoparticles of hyaluronic acid/poly(dl-lactide-co-glycolide) block copolymer

Poly(ethylene oxide)–poly(styrene oxide)–poly(ethylene oxide) copolymers: Micellization, drug solubilization, and gelling features

“…Block or graft-copolymers consisting of hydrophilic and lipophilic domains are able to form polymeric micelles and nanocompartmentalized particles, via self-assembly in an aqueous environment, that exhibit a long circulation half-life due to the stabilization provided by the hydrophilic shell. These core-shell-type nanostructures are particularly suitable to host poorly-soluble drugs and to target them to the required tissue or cells [3][4][5][6][7][8][9]. As a consequence, the local drug bioavailability and the safety of the treatment are improved [10][11][12].…”

Self-assembling polymer systems for advanced treatment of cancer and inflammation

“…The proposed system exhibited selective cytotoxicity to cancer cells overexpressing CD44. Interestingly, the PTX release rate was lower for NP containing the larger drug loadings, as observed also in other core--shell structured systems [270]. Kong et al [84,270] [262,272,273] and is attributed to the presence of another HA receptor in the liver sinusoidal endothelial cells, namely the hyaluronan receptor for endocytosis (HARE) [274].…”

Preparation, in vitro and in vivo evaluation of polymeric nanoparticles based on hyaluronic acid-poly(butyl cyanoacrylate) and D-alpha-tocopheryl polyethylene glycol 1000 succinate for tumor-targeted delivery of morin hydrate

“…The CAC value of HA-PBCA was equal to 0.00501 mg/mL, which is comparatively lower than the CAC value of different types of HA-based block copolymers intended for the delivery of anticancer therapeutics, such as HA-poly(lactic-co-glycolic acid) (HA-PLGA) (CAC =0.0089 mg/mL). 40 Moreover, HA-PBCA/TPGS exhibited lower CAC value, of 0.00398 mg/mL, as compared with HA-PBCA, due to the π-π interactions induced by the aromatic rings of tocopherol (which have been identified as a CAC-lowering factor). 41 These results underlie the high stability and the ability of both PNs and MNs to maintain their integrity upon extreme dilution in the body.…”