Self-assembled nanoplatforms for chemodynamic therapy

Meng, Xiaoyi; Sun, Zhaogang; Chu, Hongqian; Wang, Yong

doi:10.1016/j.cej.2023.147702

Chemical Engineering Journal

2024

DOI: 10.1016/j.cej.2023.147702

|View full text |Cite

Self-assembled nanoplatforms for chemodynamic therapy

Xiaoyi Meng,

Zhaogang Sun,

Hongqian Chu

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article5

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 6 publications

(1 citation statement)

References 130 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At present, CDT has gained prominence as a therapeutic method due to its economic feasibility, high efficiency, simplicity, and independence from external energy sources such as light, sound, or heat. − Studies have found that in addition to Fe 2+ , other metal ions such as Mn 2+ , Cu + , Co 2+ and V 2+ also has excellent CDT ability. − In recent years, copper nanoclusters (CuNCs) have garnered significant attention as fluorescent nanomaterials in the fields of analytical chemistry and bioimaging. , However, there is limited research on utilizing CuNCs as Fenton metal sources for catalyzing the production of ·OH in CDT and simultaneously for cellular imaging to locate the materials. The valence states of copper in the cluster primarily exist as Cu(I) and Cu(0), enabling the catalysis of ·OH generation from H 2 O 2 in the TME .…”

mentioning

confidence: 99%

CuNCs-Based pH-Responsive Degradable Nanoplatform for Enhanced CDT/IIT Synergistic Tumor Therapy in a “One-Stone-Two-Birds” Manner

Ma,

Su,

Wang

et al. 2024

ACS Materials Lett.

View full text Add to dashboard Cite

Tumor-associated macrophages (TAMs) account for 30%–50% of tumor tissue and are involved in tumorigenesis, progression, invasion, and metastasis. Thus, tumor cells are no longer the only target for tumor therapy. Here, we proposed a strategy of “one-stone-two-birds” by targeting tumor cells and M2 TAMs simultaneously with ion interference therapy (IIT) synergistic chemodynamic therapy (CDT) via a nanoplatform (CZPM). The CZPM nanoplatform was prepared by employing CuNCs as a source of light and Fenton metal, encapsulated with ZIF-8 for synergistic IIT, and finally modified with mannose. The obtained CZPM nanoplatform could enhance cellular uptake of CT26 and M2 TAMs and respond to cleavage in the acidic environment of endosomes and lysosomes, releasing Zn2+ and CuNCs for IIT synergistically enhancing CDT. In vitro and in vivo experiments confirmed that the CZPM showed significant therapeutic effects. In conclusion, an effective dual-targeting and dual-therapeutic strategy has been developed based on the CZPM nanoplatform.

show abstract

mentioning

confidence: 99%

CuNCs-Based pH-Responsive Degradable Nanoplatform for Enhanced CDT/IIT Synergistic Tumor Therapy in a “One-Stone-Two-Birds” Manner

Ma,

Su,

Wang

et al. 2024

ACS Materials Lett.

View full text Add to dashboard Cite

show abstract

Size‐Tunable Boron Nanoreactors for Boron Neutron Capture Synergistic Chemodynamic Therapy of Tumor

Li,

Zhao,

Chen

et al. 2024

Adv Healthcare Materials

View full text Add to dashboard Cite

Boron neutron capture therapy (BNCT) stands out as a noninvasive potential modality for invasive malignant tumors, with boron drugs playing a crucial role in its efficacy. Nevertheless, the development of boron drugs with biodegradability, as well as high permeability and retention effects, continues to present significant challenges. Here, we fabricate a size‐tunable boron nanoreactor (TBNR) via assembling boron nitride quantum dots (BNQDs) and Fe3+ for tumor BNCT and chemodynamic (CDT) synergistic treatment. The obtained TBNR with an appropriate size exhibits superior tumor accumulation and retention. Upon stimulation by the tumor microenvironment (TME), the contained Fe3+ undergo redox reactions with glutathione (GSH) to produce Fe2+ Fenton reagents, which in turn activate CDT function and simultaneously induce TBNR depolymerization. Subsequently, the released ultrasmall BNQDs exhibit intra‐deep penetration characteristic and are fully enriched at the tumor site. The in vivo experiments reveal that TBNR possesses excellent biocompatibility and superior synergistic anti‐tumor ability post neutron irradiation, resulting in significant shrinkage of subcutaneous 4T1 tumors. Moreover, the TBNR‐mediated BNCT has triggered an obvious immune response, which contributes to the long‐term suppression of tumors after neutron irradiation. To conclude, this study provides a new approach for constructing more efficient versatile nanocarriers for BNCT‐induced combination cancer therapies.

show abstract

Intraparticle Electron Transfer for Long‐Lasting Tumor Chemodynamic Therapy

Yu,

Yan,

Zhao

et al. 2024

Advanced Science

View full text Add to dashboard Cite

Chemodynamic therapy (CDT) is a novel tumor treatment method by using hydroxyl radicals (•OH) to kill cancer cells. However, its therapeutic effects are strictly confined by the short lifespan of •OH and reduced •OH generation speed. Herein, an effective CDT is achieved by both improving •OH lifetime and long‐lasting generating •OH through intraparticle electron transfer within heterogeneous nanoparticles (NPs). These heterogeneous NPs are composed of evenly distributed Cu and Fe3O4 (CFO NPs) with large interaction interfaces, and electrons tend to transfer from Cu to Fe3O4 for the appearance of ≡Cu2+ and increase in ≡Fe2+. The generated ≡Cu2+ can interact with GSH, which prolongs the lifespan of •OH, produces ≡Cu+ for higher speed •OH generation with H2O2, and induces cell ferroptosis for tumor therapy. The improved ≡Fe2+ can also improve the •OH release under H2O2 until Cu is depleted. As a result, a sustainable •OH generation is achieved to promote cell apoptosis for effective tumor therapy. Since H2O2 and GSH are only overexpressed at tumor, and CFO NPs can degrade in the tumor microenvironment, these NPs are with high biosafety and can be metabolized by urine. This work provides a novel biomaterial for effective cancer CDT through intraparticle electron transfer.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Self-assembled nanoplatforms for chemodynamic therapy

Cited by 6 publications

References 130 publications

CuNCs-Based pH-Responsive Degradable Nanoplatform for Enhanced CDT/IIT Synergistic Tumor Therapy in a “One-Stone-Two-Birds” Manner

CuNCs-Based pH-Responsive Degradable Nanoplatform for Enhanced CDT/IIT Synergistic Tumor Therapy in a “One-Stone-Two-Birds” Manner

Size‐Tunable Boron Nanoreactors for Boron Neutron Capture Synergistic Chemodynamic Therapy of Tumor

Intraparticle Electron Transfer for Long‐Lasting Tumor Chemodynamic Therapy

Contact Info

Product

Resources

About