Self-assembled oleylamine grafted hyaluronic acid polymersomes for delivery of vancomycin against methicillin resistant Staphylococcus aureus (MRSA)

Walvekar, Pavan; Gannimani, Ramesh; Salih, Mohammed; Makhathini, Sifiso S.; Mocktar, Chunderika; Govender, Thirumala

doi:10.1016/j.colsurfb.2019.110388

Cited by 61 publications

(41 citation statements)

References 38 publications

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“…Polymeric nanostructured systems allow precise drug release based on different methods, such as diffusion, elution, or chemically/stimuli-controlled, and they are synthesized from natural precursors, such as chitosan, collagen, or gelatine, which makes them biocompatible and less toxic. Synthetic precursors, such as polylactic acid or polyethylene glycol, can also be found [ 265 , 266 ]. Developed phosphatidylcholine–chitosan hybrid nanoparticles coated with gentamycin confirmed the capacity of the construct to avoid biofilm formation and bacterial growth in both Gram-negative and -positive bacteria [ 267 ].…”

Section: Strategies Based On Drug Delivery Systemsmentioning

confidence: 99%

“…Developed phosphatidylcholine–chitosan hybrid nanoparticles coated with gentamycin confirmed the capacity of the construct to avoid biofilm formation and bacterial growth in both Gram-negative and -positive bacteria [ 267 ]. Another variant nanocapsule demonstrated that the hydrophilic polymersomes encapsulated vancomycin, which also serves to treat infections more efficiently, in this case, those caused by methicillin-resistant S. aureus [ 266 ].…”

Section: Strategies Based On Drug Delivery Systemsmentioning

confidence: 99%

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Progress in Alternative Strategies to Combat Antimicrobial Resistance: Focus on Antibiotics

et al. 2022

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Antibiotic resistance, and, in a broader perspective, antimicrobial resistance (AMR), continues to evolve and spread beyond all boundaries. As a result, infectious diseases have become more challenging or even impossible to treat, leading to an increase in morbidity and mortality. Despite the failure of conventional, traditional antimicrobial therapy, in the past two decades, no novel class of antibiotics has been introduced. Consequently, several novel alternative strategies to combat these (multi-) drug-resistant infectious microorganisms have been identified. The purpose of this review is to gather and consider the strategies that are being applied or proposed as potential alternatives to traditional antibiotics. These strategies include combination therapy, techniques that target the enzymes or proteins responsible for antimicrobial resistance, resistant bacteria, drug delivery systems, physicochemical methods, and unconventional techniques, including the CRISPR-Cas system. These alternative strategies may have the potential to change the treatment of multi-drug-resistant pathogens in human clinical settings.

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Section: Strategies Based On Drug Delivery Systemsmentioning

confidence: 99%

Section: Strategies Based On Drug Delivery Systemsmentioning

confidence: 99%

Progress in Alternative Strategies to Combat Antimicrobial Resistance: Focus on Antibiotics

et al. 2022

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“…Spherical self-assembled oleylamine grafted HA [ 132 , 133 ] polymersomes with bilayered morphology encapsulating VAN with sizes 196.1–360.9 nm and a negative zeta potential exhibited sustained drug release for 72 h, and showed a more powerful impact on MRSA membrane and pronouncedly higher antibacterial activity against MRSA than free drug (IC 50 of 1.9 μg/mL vs 7.8 μg/mL), resulting in higher cell death [ 247 ]. Polyelectrolyte complexes of colistin with HA, showing a size of 210–250 nm and a zeta-potential of −19 mV, released 45% and 85% of colistin in 15 and 60 min, respectively, compared to complete (100%) release of drug in 15 min, whereby the antibacterial activity against P. aeruginosa (MIC of 1 μg/mL) did not differ from that of the pure drug [ 248 ].…”

Section: Applied Nanomaterialsmentioning

confidence: 99%

Advances in Nanostructures for Antimicrobial Therapy

Jampílek

Kráľová

2022

Materials

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Microbial infections caused by a variety of drug-resistant microorganisms are more common, but there are fewer and fewer approved new antimicrobial chemotherapeutics for systemic administration capable of acting against these resistant infectious pathogens. Formulation innovations of existing drugs are gaining prominence, while the application of nanotechnologies is a useful alternative for improving/increasing the effect of existing antimicrobial drugs. Nanomaterials represent one of the possible strategies to address this unfortunate situation. This review aims to summarize the most current results of nanoformulations of antibiotics and antibacterial active nanomaterials. Nanoformulations of antimicrobial peptides, synergistic combinations of antimicrobial-active agents with nitric oxide donors or combinations of small organic molecules or polymers with metals, metal oxides or metalloids are discussed as well. The mechanisms of actions of selected nanoformulations, including systems with magnetic, photothermal or photodynamic effects, are briefly described.

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“…Another study by Walvekar et al investigated the antibacterial effects of hyaluronic acid-oleylamine conjugates with different degrees of conjugation as drug nanocarriers against methicillin-resistant S. aureus. Precisely, the vancomycin antibiotic was encapsulated into polymersomes, which are nanocapsules comprising hydrophilic polymers grafted with long fatty acids that have the capacity to self-assemble into spherical drug carriers [118]. Moreover, Oliveira et al developed a double-layer biomembrane comprising chitosan, hydroxypropyl methylcellulose, and lidocaine chloride as an anesthetic drug as the first layer and polymyxin B sulfate antibiotic-containing sodium alginate nanoparticles as the second layer for wound treatment [119].…”

Section: Antibacterial Nanoparticlesmentioning

confidence: 99%

Polymeric Nanoparticles for Antimicrobial Therapies: An up-to-date Overview

et al. 2021

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Despite the many advancements in the pharmaceutical and medical fields and the development of numerous antimicrobial drugs aimed to suppress and destroy pathogenic microorganisms, infectious diseases still represent a major health threat affecting millions of lives daily. In addition to the limitations of antimicrobial drugs associated with low transportation rate, water solubility, oral bioavailability and stability, inefficient drug targeting, considerable toxicity, and limited patient compliance, the major cause for their inefficiency is the antimicrobial resistance of microorganisms. In this context, the risk of a pre-antibiotic era is a real possibility. For this reason, the research focus has shifted toward the discovery and development of novel and alternative antimicrobial agents that could overcome the challenges associated with conventional drugs. Nanotechnology is a possible alternative, as there is significant evidence of the broad-spectrum antimicrobial activity of nanomaterials and nanoparticles in particular. Moreover, owing to their considerable advantages regarding their efficient cargo dissolving, entrapment, encapsulation, or surface attachment, the possibility of forming antimicrobial groups for specific targeting and destruction, biocompatibility and biodegradability, low toxicity, and synergistic therapy, polymeric nanoparticles have received considerable attention as potential antimicrobial drug delivery agents. In this context, the aim of this paper is to provide an up-to-date overview of the most recent studies investigating polymeric nanoparticles designed for antimicrobial therapies, describing both their targeting strategies and their effects.

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Self-assembled oleylamine grafted hyaluronic acid polymersomes for delivery of vancomycin against methicillin resistant Staphylococcus aureus (MRSA)

Cited by 61 publications

References 38 publications

Progress in Alternative Strategies to Combat Antimicrobial Resistance: Focus on Antibiotics

Progress in Alternative Strategies to Combat Antimicrobial Resistance: Focus on Antibiotics

Advances in Nanostructures for Antimicrobial Therapy

Polymeric Nanoparticles for Antimicrobial Therapies: An up-to-date Overview

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