Self-assembled organic nanomedicine enables ultrastable photo-to-heat converting theranostics in the second near-infrared biowindow

Xiang, Huijing; Zhao, Lingzhi; Yu, Luodan; Chen, Hongzhong; Wei, Chenyang; Chen, Yu; Zhao, Yanli

doi:10.1038/s41467-020-20566-6

Cited by 119 publications

(73 citation statements)

References 50 publications

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“…The temperature increment is still remarkable when the light power density drops to 1.00 W/cm 2 , which is generally regarded as the tolerance threshold of NIR-II for human skin. 29 The changes of surface temperature retain almost the same during 10 consecutive on-off cycles of light irradiation, satisfying the needs of high photostability and thermal stability (Supporting Information Figure S7). The in vitro NIR-II photothermal conversion of TBDOPV-DT with the combination of skin tissue optical clearing technology was testified based on the measurement apparatus as shown in Supporting Information Figure S8.…”

Section: In Vitro Enhanced Nir-ii Photothermal Conversionmentioning

confidence: 57%

Second Near-Infrared Photothermal Therapy with Superior Penetrability through Skin Tissues

Chu

Liao

et al. 2022

CCS Chem

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Photothermal therapy (PTT) triggered by the second near-infrared light (NIR-II, 1000-1400 nm) has shown great potentials in tumor ablation because of its better tissue penetrability. However, even NIR-II PTT is still far from the desirable treatment of those tumors underneath skin, owing to the light scattering effect among skin components. This research aims to promote the NIR-II penetrability of skin tissue by weakening the light scattering effect led by the refractive index inhomogeneity among skin constituents. This strategy allows for a notable improvement of NIR-II transmittance from 30% to 70% through in vivo mice skin. In animal experiments, the local temperature of tumor tissue in the experiment group is 14.1°C higher than that in the control group due to superior tissue penetration, which is thus responsible for the excellent therapeutic effects of complete ablation without any reoccurrence. Such a strategy not only achieves perfect PTT effect, but benefits the development of other light-related biological applications.

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Section: In Vitro Enhanced Nir-ii Photothermal Conversionmentioning

confidence: 57%

Second Near-Infrared Photothermal Therapy with Superior Penetrability through Skin Tissues

Chu

Liao

et al. 2022

CCS Chem

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“…Small organic NIR‐II absorbing PTAs are proposed to be the most promising PTAs due to their better biocompatibility and higher biodegradability comparing to inorganic and conjugated polymer PTAs. To the best of our knowledge, only four examples of small organic NIR‐II absorbing PTAs were reported by Fang, [29] Ling, [30] Lee [31] and Chen [32] groups. Fang and co‐workers reported PTA based on IR‐1061 for photoacoustic imaging and PTT of hepatocellular carcinoma, and the photothermal conversion efficiency (PCE) of this PTA is determined to be 45.25 % under 1064 nm laser excitation (1 W cm −2 ) [29] .…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the IR‐SS NPs show a PCE of 77 % under 1064 nm laser excitation with a light intensity of 1 W cm −2 . Recently, Chen and co‐workers designed a highly stable organic NIR‐II absorbing PTA (Nano‐BFF) with PCE of 34.3 % via co‐assembling NIR‐I absorbing boron difluoride formazanate (BFF) dye with a biocompatible polymer, endowing the Nano‐BFF with remarkable PTT performance in the NIR‐II region [32] . Furthermore, currently reported NIR‐II absorbing PTAs based on inorganic and polymeric materials show considerably low PCE values (typically ranging from 40–60 %, Table S1) comparing to the NIR‐I PTAs.…”

Section: Introductionmentioning

confidence: 99%

A Borondifluoride‐Complex‐Based Photothermal Agent with an 80 % Photothermal Conversion Efficiency for Photothermal Therapy in the NIR‐II Window

et al. 2021

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Small organic photothermal agents (SOPTAs) that absorb in the second near‐infrared (NIR‐II, 1000–1700 nm) window are highly desirable in photothermal therapy for their good biocompatibility and deeper tissue penetration. However, the design of NIR‐II absorbing SOPTAs remains a great challenge. Herein, we report that molecular engineering of BF2 complex via strengthening the donor‐acceptor conjugation and increasing the intramolecular motions is an efficient strategy to achieve NIR‐II absorbing SOPTAs with high photothermal performance. Based on this strategy, a BF2 complex, BAF4, was designed and synthesized. BAF4 exhibits an intense absorption maximum at 1000 nm and negligible fluorescence. Notably, the nanoparticles of BAF4 achieve a high photothermal conversion efficiency value of 80 % under 1064 nm laser irradiation (0.75 W cm−2). In vitro and in vivo studies reveal the great potential of BAF4 nanoparticles in photoacoustic imaging‐guided photothermal therapy in the NIR‐II window.

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“…Here we choose near infrared (NIR) (808 nm) as the applied stimulus for its good controllability including power density, duration, and heating range. [45][46][47] In Figure 3a, owing to the high conversion efficiency of the LM-NPs, the hydrogel can be heated over the lower critical solution temperature (LCST, at around 26.5 °C) from 24.5 °C within 1 s. [31] According to the cooling curve after irradiation in Figure 3b and Figure S5, Supporting Information, LM-NPs exhibit a desired photothermal conversion efficiency (48.25%) which is higher than commercial Au-NR1 (17%)), benefit the efficient lightwriting while avoiding excessive temperatures (<30 °C). [28,48] Moreover, temperature of the writing area will quickly reduce after removing NIR stimulus, indicating that the obtained hydrogel possesses a desired self-erasing ability.…”

Section: Multi-stage Responsive Mechanismmentioning

confidence: 99%

Multistage Responsive Materials for Real‐time, Reversible, and Sustainable Light‐Writing

Liu

Guo

Zhang

et al. 2021

Adv Funct Materials

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Stimulus-responsive materials with designable integrated functions bridge the intelligent systems in future lifestyles with the Internet of Things (IoT). The growing trend for IoT and corresponding advanced devices will involve a great number of electronic disposables, which may place heavy burdens on the environment. Here, an elaborately designed multistage responsive material is reported for real-time, reversible light-writing based on organized stage-by-stage responsive behaviors and polarity-dependent physicochemical fluorescence response, where the stimulus is accurately delivered through a completely reversible "light-heat-fluorescence" pathway. The resulted materials can be pollution-freely written by hand-controlled near-infrared laser within 5 s, spontaneously erased within 20 s, and exhibit excellent re-writing ability (more than 5000 times while the variance of chromaticity coordinates <0.0008), which is difficult to achieve by traditional laser writing technologies. This study is a step toward high-performance long-life functional devices based on reversible multistage responsive materials for future IoT lifestyles.

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Self-assembled organic nanomedicine enables ultrastable photo-to-heat converting theranostics in the second near-infrared biowindow

Cited by 119 publications

References 50 publications

Second Near-Infrared Photothermal Therapy with Superior Penetrability through Skin Tissues

Second Near-Infrared Photothermal Therapy with Superior Penetrability through Skin Tissues

A Borondifluoride‐Complex‐Based Photothermal Agent with an 80 % Photothermal Conversion Efficiency for Photothermal Therapy in the NIR‐II Window

Multistage Responsive Materials for Real‐time, Reversible, and Sustainable Light‐Writing

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