Self-assembling hydrogels from reverse-engineered silk

Seib, F. Philipp

doi:10.1016/b978-0-08-102015-9.00003-4

Cited by 3 publications

(1 citation statement)

References 79 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bombyx mori silk) (Table I ). For this reason, we first provide a brief background of the B. mori silk structure (reviewed in more detail in ( 28 )).…”

Section: Introductionmentioning

confidence: 99%

A Review of the Emerging Role of Silk for the Treatment of the Eye

2018

Self Cite

View full text Add to dashboard Cite

Silk is a remarkable biopolymer with a long history of medical use. Silk fabrications have a robust track record for load-bearing applications, including surgical threads and meshes, which are clinically approved for use in humans. The progression of top-down and bottom-up engineering approaches using silk as the basis of a drug delivery or cell-loaded matrix helped to re-ignite interest in this ancient material. This review comprehensively summarises the current applications of silk for tissue engineering and drug delivery, with specific reference to the eye. Additionally, the review also covers emerging trends for the use of silk as a biologically active biopolymer for the treatment of eye disorders. The review concludes with future capabilities of silk to contribute to advanced, electronically-enhanced ocular drug delivery concepts.

show abstract

“…Bombyx mori silk) (Table I ). For this reason, we first provide a brief background of the B. mori silk structure (reviewed in more detail in ( 28 )).…”

Section: Introductionmentioning

confidence: 99%

A Review of the Emerging Role of Silk for the Treatment of the Eye

2018

Self Cite

View full text Add to dashboard Cite

show abstract

The Biomedical Use of Silk: Past, Present, Future

Holland

Numata

Rnjak‐Kovacina

et al. 2018

Adv Healthcare Materials

Self Cite

614

509

View full text Add to dashboard Cite

Humans have long appreciated silk for its lustrous appeal and remarkable physical properties, yet as the mysteries of silk are unraveled, it becomes clear that this outstanding biopolymer is more than a high‐tech fiber. This progress report provides a critical but detailed insight into the biomedical use of silk. This journey begins with a historical perspective of silk and its uses, including the long‐standing desire to reverse engineer silk. Selected silk structure–function relationships are then examined to appreciate past and current silk challenges. From this, biocompatibility and biodegradation are reviewed with a specific focus of silk performance in humans. The current clinical uses of silk (e.g., sutures, surgical meshes, and fabrics) are discussed, as well as clinical trials (e.g., wound healing, tissue engineering) and emerging biomedical applications of silk across selected formats, such as silk solution, films, scaffolds, electrospun materials, hydrogels, and particles. The journey finishes with a look at the roadmap of next‐generation recombinant silks, especially the development pipeline of this new industry for clinical use.

show abstract