Self‐assembling Linear and Star Shaped Poly(ϵ‐caprolactone)/poly[(meth)acrylic acid] Block Copolymers as Carriers of Indomethacin and Quercetin

Bury, Katarzyna; Prez, Filip Du; Neugebauer, Dorota

doi:10.1002/mabi.201300179

Cited by 24 publications

(12 citation statements)

References 38 publications

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“…The results show that the CAC decreased from 1.32 µg/ mL (0.20 µM) to 0.35 µg/mL (0.02 µM) as the PCL arm length increased from 4.7 to 14.2 kDa (Table 2). This is consistent with other reports showing that self-assembly occurs at lower polymer concentrations with the increase in the molecular weight of the hydrophobic block [19,31].…”

Section: Self-assembly and Micellization Of A 2 B Miktoarm Polymerssupporting

confidence: 93%

Miktoarm Star Micelles Containing Curcumin Reduce Cell Viability of Sensitized Glioblastoma

Soliman¹

2014

J Nanomedine Biotherapeutic Discov

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Glioblastoma multiforme (GBM) is the most common and lethal primary intracranial tumor in humans. Monotherapeutic interventions have not been successful. The objective of the current studies was to establish the effective combination therapy consisting of pifitrin as a sensitizer, and curcumin as therapeutic incorporated into miktoarm micelles. A 2 B type miktoarm stars were prepared using a combination of click chemistry with ring opening polymerization on a core with orthogonal functionalities. These self-assemble into spherical micelles with hydrophobic core and hydrophilic corona structure. Micellar delivery systems for curcumin based on these miktoarm star polymers were prepared, characterized and tested on cultures sensitized with pifitrin. The results show that: (1) pifitrin and temozolamide in combination with curcumin cause significant cell death compared with the individual therapeutics (incorporated or not in micelles), and (2) repeated exposure to the same treatments is necessary to fully prevent a re-growth of glioblastoma cells both in 2D and 3D cultures. Although the incorporation of curcumin into A 2 B star polymer micelles did not increase the extent of cell death compared with curcumin alone, the advantage of micelles is that they significantly increase the aqueous solubility of curcumin and sustain its release; this will likely reduce the frequency of its administration required to be effective in vivo. A 2 B miktoarm polymers could be a new viable delivery system for curcumin and other anticancer drugs with similar limitations.

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Section: Self-assembly and Micellization Of A 2 B Miktoarm Polymerssupporting

confidence: 93%

Miktoarm Star Micelles Containing Curcumin Reduce Cell Viability of Sensitized Glioblastoma

Soliman¹

2014

J Nanomedine Biotherapeutic Discov

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“…As can be expected, the increase in the substitution by the DDA group promotes the increase of EE, due to the presence of more hydrophobic sites for interaction with QCT. The EE and DL for these samples are superior to those reported in similar studies . In spite of these observations, it is necessary to emphasize that the encapsulation process is complex and can be influenced by several factors, including CS molar mass, hydrophobic chain length, chemical drug structure, and drug–solvent interactions.…”

Section: Resultsmentioning

confidence: 54%

Self‐aggregated nanoparticles of N‐dodecyl,N′‐glycidyl(chitosan) as pH‐responsive drug delivery systems for quercetin

Pedro

Pereira

Goycoolea

et al. 2017

J of Applied Polymer Sci

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In this study, pH‐responsive amphiphilic chitosan (CS) nanoparticles were used to encapsulate quercetin (QCT) for sustained release in cancer therapy. The novel CS derivatives were obtained by synthesis with 2,3‐epoxy‐1‐propanol, also known as glycidol, followed by acylation with dodecyl aldehyde. Characterization was performed by spectroscopic, viscosimetric, and size‐determination methods. Critical aggregation concentration, morphology, entrapment efficiency, drug release profile, cytotoxicity, and hemocompatibility studies were also carried out. The average size distribution of the self‐assembling nanoparticles measured by dynamic light scattering ranged from 140 to 300 nm. In vitro QCT release and Korsmeyer–Peppas model indicated that pH had a major role in drug release. Cytotoxicity assessments indicated that the nanoparticles were non‐cytotoxic. 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide assay further revealed that QCT‐loaded nanoparticles could inhibit MCF‐7 cell growth. In vitro erythrocyte‐induced hemolysis indicated the good hemocompatibility of the nanoparticles. These results suggest that the synthesized copolymers might be potential carriers for hydrophobic drugs in cancer therapy. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45678.

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“…In some cases of loaded systems (I, III, IV) the measurements showed a few generation of particles with different sizes in the sample, what may indicate the presence of unimers, as well as formation of micelles, aggregates, and even superaggregates (Figure 7). Generally the polymeric micelles are widely studied as the drug delivery systems, mostly for anti-cancer and anti-inflammatory therapy [34][35][36][37][38][39][40][41]. Satisfactory results have encouraged us to investigate the polymeric micelles also for encapsulation of cosmetic substances that improve the skin functions and appearance.…”

Section: Micellization and Bioactive Substance Loadingmentioning

confidence: 99%

Retinol derivative as bioinitiator in the synthesis of hydroxyl-functionalized polymethacrylates for micellar delivery systems

Odrobińska¹,

Neugebauer²

2019

Express Polym. Lett.

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Amphiphilic copolymers containing 2-hydroxyethyl methacrylate (HEMA) and methyl methacrylate (MMA) units were synthesized by controlled atom transfer radical polymerization (ATRP) applying bromoester modified retinol (RETBr) as a novel initiator. Analogous series of copolymers with adjustable hydrophilic-hydrophobic balance was obtained with the use of a standard initiator, i.e. ethyl α-bromoisobutyrate (EBriB). The self-assembling particles, prepared by the solvent evaporation, were loaded with vitamin C (VitC) or ferulic acid (FA). The hydrophilic/hydrophobic ratio in the copolymer was indicated as a crucial factor to regulate efficiencies of encapsulation processes in the range of 53-98%. In vitro release of bioactive substance was carried out in phosphate buffer solution (PBS) at pH 7.4 with the maximum amount of VitC after 1h (27-62%) or FA within 2 h (71-97%). The polymeric systems with satisfactory encapsulation characteristics and release profiles are attractive micellar carriers of antioxidants, which, due to their activities could be also delivered using the popular approaches in cosmetology like masks, under-eye patches, or wraps.

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Self‐assembling Linear and Star Shaped Poly(ϵ‐caprolactone)/poly[(meth)acrylic acid] Block Copolymers as Carriers of Indomethacin and Quercetin

Cited by 24 publications

References 38 publications

Miktoarm Star Micelles Containing Curcumin Reduce Cell Viability of Sensitized Glioblastoma

Miktoarm Star Micelles Containing Curcumin Reduce Cell Viability of Sensitized Glioblastoma

Self‐aggregated nanoparticles of N‐dodecyl,N′‐glycidyl(chitosan) as pH‐responsive drug delivery systems for quercetin

Retinol derivative as bioinitiator in the synthesis of hydroxyl-functionalized polymethacrylates for micellar delivery systems

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