Self-assembling peptide assemblies bound to ZnS nanoparticles and their interactions with mammalian cells

Nakatsuka, Nako; Barnaby, Stacey N.; Tsiola, Areti; Fath, Karl R.; Williams, Brian A.; Banerjee, Ipsita A.

doi:10.1016/j.colsurfb.2012.10.009

Cited by 12 publications

(5 citation statements)

References 68 publications

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“…While nature provides a host of material compositions, biocombinatorial selection methods have provided rapid routes to the identification of new peptides with affinity for different inorganic compositions not typically observed in nature, including noble metals (Au, Pd, Pt, etc. ), metal sulfides (ZnS and CdS), and metal oxides (Cu 2 O, ZnO, etc.) .…”

Section: Introductionmentioning

confidence: 99%

Peptide-Driven Fabrication of Catalytically Reactive Rhodium Nanoplates

Parab

Naik

Knecht

2018

ACS Appl. Nano Mater.

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Here we present the use of a well-known materials binding peptide for the generation of highly catalytically reactive Rh nanoplates. To this end, the A3 peptide, originally isolated with affinity for Ag, but with known abilities to bind Au, was used to generate Rh nanomaterials in solution. Rh was selected due to its established catalytic reactivity for numerous reactions; however, the preparation of materials of this composition typically requires high reaction temperatures and potentially caustic conditions. By use of the A3 peptide, Rh nanoplates can be generated in water, at room temperature, on the benchtop. The final structures were not spherical materials, which is typical for peptide-capped nanoparticles, but were plate-like in morphology. The materials were fully characterized and analyzed for olefin hydrogenation reactions. For this, the peptide-capped Rh nanoplates were highly reactive for alkene hydrogenation; however, the hydrogenation of alkynes was exceedingly slow and potentially blocked the surface to greatly inhibit reactivity. These results present a pathway toward the fundamental understanding of the structure/function relationship of peptide-capped nanocatalysts, which could be exploited for the future design of new materials with enhanced reactivity that are prepared under ambient conditions.

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Section: Introductionmentioning

confidence: 99%

Peptide-Driven Fabrication of Catalytically Reactive Rhodium Nanoplates

Parab

Naik

Knecht

2018

ACS Appl. Nano Mater.

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“…Nanoparticles offer opportunities to become a system for targeted drug delivery as well as imaging agent, thanks to their multi-functionalization [3]. Several studies dealing with the biomedical application of ZnS have been published recently [4–8]. In these papers, as well as in plenty of others, the results show that the prepared nanoparticles based on zinc sulfide exhibit high quantum yield, which can be utilized in fluorescence images for the better resolution of the appropriate biological structures.…”

Section: Introductionmentioning

confidence: 99%

Mechanochemistry of Chitosan-Coated Zinc Sulfide (ZnS) Nanocrystals for Bio-imaging Applications

et al. 2017

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The ZnS nanocrystals were prepared in chitosan solution (0.1 wt.%) using a wet ultra-fine milling. The obtained suspension was stable and reached high value of zeta potential (+57 mV). The changes in FTIR spectrum confirmed the successful surface coating of ZnS nanoparticles by chitosan. The prepared ZnS nanocrystals possessed interesting optical properties verified in vitro. Four cancer cells were selected (CaCo-2, HCT116, HeLa, and MCF-7), and after their treatment with the nanosuspension, the distribution of ZnS in the cells was studied using a fluorescence microscope. The particles were clearly seen; they passed through the cell membrane and accumulated in cytosol. The biological activity of the cells was not influenced by nanoparticles, they did not cause cell death, and only the granularity of cells was increased as a consequence of cellular uptake. These results confirm the potential of ZnS nanocrystals using in bio-imaging applications.

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“…The biocompatibility of chitosan has also drawn attention from researchers for potential applications in the biomedical field. [257][258][259][260][261] Zinc sulfide (ZnS) nanoparticles are a class of fluorescence imaging agents with high resolution thanks to their high quantum yield. [262,263] However, the inorganic nanoparticles have to be covered by a biocompatible organic material, where chitosan makes a good fit for the purpose.…”

Section: Mechanochemical Texturing And/or Blending From Chitin or Chi...mentioning

confidence: 99%

“…The biocompatibility of chitosan has also drawn attention from researchers for potential applications in the biomedical field [257–261] . Zinc sulfide (ZnS) nanoparticles are a class of fluorescence imaging agents with high resolution thanks to their high quantum yield [262,263] .…”

Section: Mechanochemical Conversion Of Biomass and Applicationsmentioning

confidence: 99%